Entity Details

Primary name PYGL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06737
EntryNamePYGL_HUMAN
FullNameGlycogen phosphorylase, liver form
TaxID9606
Evidenceevidence at protein level
Length847
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesPYGL

GO terms

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GOName
GO:0002060 purine nucleobase binding
GO:0005524 ATP binding
GO:0005536 glucose binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005977 glycogen metabolic process
GO:0005980 glycogen catabolic process
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process
GO:0008184 glycogen phosphorylase activity
GO:0009617 response to bacterium
GO:0016208 AMP binding
GO:0019842 vitamin binding
GO:0030170 pyridoxal phosphate binding
GO:0032052 bile acid binding
GO:0034774 secretory granule lumen
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0043312 neutrophil degranulation
GO:0070062 extracellular exosome
GO:0070266 necroptotic process
GO:0102250 linear malto-oligosaccharide phosphorylase activity
GO:0102499 SHG alpha-glucan phosphorylase activity
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000811 Glycosyl transferase, family 35FamilyFamily
IPR011833 Glycogen/starch/alpha-glucan phosphorylaseFamilyFamily
IPR035090 Phosphorylase pyridoxal-phosphate attachment siteSiteConserved site

Diseases

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Disease IDSourceNameDescription
232700 OMIMGlycogen storage disease 6 (GSD6)A metabolic disorder characterized by mild to moderate hypoglycemia, mild ketosis, growth retardation, and prominent hepatomegaly. Heart and skeletal muscle are not affected. The disease is caused by variants affecting the gene represented in this entry.