Entity Details

Primary name HMOX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09601
EntryNameHMOX1_HUMAN
FullNameHeme oxygenase 1
TaxID9606
Evidenceevidence at protein level
Length288
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesHMOX1

GO terms

Show/Hide Table
GOName
GO:0001525 angiogenesis
GO:0001935 endothelial cell proliferation
GO:0002246 wound healing involved in inflammatory response
GO:0002686 negative regulation of leukocyte migration
GO:0004392 heme oxygenase (decyclizing) activity
GO:0004630 phospholipase D activity
GO:0005198 structural molecule activity
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005901 caveola
GO:0006788 heme oxidation
GO:0006879 cellular iron ion homeostasis
GO:0006979 response to oxidative stress
GO:0007264 small GTPase mediated signal transduction
GO:0007588 excretion
GO:0008217 regulation of blood pressure
GO:0008219 cell death
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0014806 smooth muscle hyperplasia
GO:0016020 membrane
GO:0016239 positive regulation of macroautophagy
GO:0016242 negative regulation of macroautophagy
GO:0019221 cytokine-mediated signaling pathway
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0031670 cellular response to nutrient
GO:0032722 positive regulation of chemokine production
GO:0032764 negative regulation of mast cell cytokine production
GO:0034101 erythrocyte homeostasis
GO:0034383 low-density lipoprotein particle clearance
GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron
GO:0034605 cellular response to heat
GO:0035094 response to nicotine
GO:0035556 intracellular signal transduction
GO:0042167 heme catabolic process
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043305 negative regulation of mast cell degranulation
GO:0043392 negative regulation of DNA binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043627 response to estrogen
GO:0045048 protein insertion into ER membrane
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0055072 iron ion homeostasis
GO:0071243 cellular response to arsenic-containing substance
GO:0071276 cellular response to cadmium ion
GO:0071456 cellular response to hypoxia
GO:0072719 cellular response to cisplatin
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0097421 liver regeneration
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1904036 negative regulation of epithelial cell apoptotic process
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation

Subcellular Location

Show/Hide Table
Subcellular Location
Endoplasmic reticulum membrane
Microsome

Domains

Show/Hide Table
DomainNameCategoryType
IPR002051 Haem oxygenaseFamilyFamily
IPR016053 Haem oxygenase-likeFamilyFamily
IPR016084 Haem oxygenase-like, multi-helicalFamilyHomologous superfamily
IPR018207 Haem oxygenase conserved siteSiteConserved site

Diseases

Show/Hide Table
Disease IDSourceNameDescription
614034 OMIMHeme oxygenase 1 deficiency (HMOX1D)A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00163 Vitamin EDrugbanksmall molecule
DB01942 Formic acidDrugbanksmall molecule
DB02073 Biliverdine IX AlphaDrugbanksmall molecule
DB02468 12-PhenylhemeDrugbanksmall molecule
DB03906 2-PhenylhemeDrugbanksmall molecule
DB04803 VerdohemeDrugbanksmall molecule
DB04912 StannsoporfinDrugbanksmall molecule
DB06914 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLEDrugbanksmall molecule
DB07342 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanoneDrugbanksmall molecule
DB09221 PolaprezincDrugbanksmall molecule
DB14001 alpha-Tocopherol succinateDrugbanksmall molecule
DB14002 D-alpha-Tocopherol acetateDrugbanksmall molecule

Interactions

43 interactions

InteractorPartnerSourcesPublicationsLink
HMOX1_HUMANCREB3_HUMANBioGRID, IntAct, MINT21516116 31515488 details
HMOX1_HUMANARLY_HUMANBioGRID, IntAct21988832 details
HMOX1_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
HMOX1_HUMANPOTE1_HUMANbhf-ucl, BioGRID21044950 details
HMOX1_HUMANSTX1A_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANMSMO1_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANCY561_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANELOV6_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANTM14B_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANT4S19_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANERGI3_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANELOV4_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANF174A_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANPDZ1I_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANJAGN1_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANSC11C_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANTLCD4_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANGP152_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANCOQ9_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANAR13B_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANF210B_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANF209A_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANCPLX4_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANMOT2_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANCD79A_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANCYBR1_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANCRUM3_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANELOV5_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANPE2R4_HUMANBioGRID, MINT28298427 details
HMOX1_HUMANSMO_HUMANBioGRID, MINT28298427 details
HMOX1_HUMANKASH5_HUMANBioGRID25416956 details
HMOX1_HUMANLMNA_HUMANBioGRID24623722 details
HMOX1_HUMANTMIE_HUMANBioGRID32296183 details
HMOX1_HUMANHMOX1_HUMANBioGRID, HPRD12500973 details
HMOX1_HUMANUFD1_HUMANBioGRID18544348 details
HMOX1_HUMANPSMD2_HUMANBioGRID18544348 details
HMOX1_HUMANSQSTM_HUMANBioGRID31521246 details
HMOX1_HUMANSIAH2_HUMANBioGRID32042051 details
HMOX1_HUMANAKT1_HUMANHPRD15581622 details
HMOX1_HUMANNCPR_HUMANHPRD12626517 details
HMOX1_HUMANBLVRB_HUMANHPRD12626517 details
HMOX1_HUMANNOS1_HUMANHPRD11849436 details