Entity Details

Primary name CO7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10643
EntryNameCO7_HUMAN
FullNameComplement component C7
TaxID9606
Evidenceevidence at protein level
Length843
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesC7

GO terms

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GOName
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0006883 cellular sodium ion homeostasis
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0019835 cytolysis
GO:0030449 regulation of complement activation
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000436 Sushi/SCR/CCP domainDomainDomain
IPR000884 Thrombospondin type-1 (TSP1) repeatRepeatRepeat
IPR001862 Membrane attack complex component/perforin/complement C9FamilyFamily
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR003884 Factor I / membrane attack complexDomainDomain
IPR020863 Membrane attack complex component/perforin domain, conserved siteSiteConserved site
IPR020864 Membrane attack complex component/perforin (MACPF) domainDomainDomain
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR035976 Sushi/SCR/CCP superfamilyFamilyHomologous superfamily
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily
IPR036383 Thrombospondin type-1 (TSP1) repeat superfamilyFamilyHomologous superfamily
IPR037564 Complement component C7FamilyFamily
IPR040729 Kazal-type serine protease inhibitor domainDomainDomain

Diseases

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Disease IDSourceNameDescription
610102 OMIMComplement component 7 deficiency (C7D)A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
CO7_HUMANCO5_HUMANBioGRID, HPRD, IntAct1387399 26841837 30552328 details
CO7_HUMANCLUS_HUMANBioGRID, HPRD8345200 details
CO7_HUMANPLMN_HUMANBioGRID, HPRD7814888 details