Entity Details

Primary name NOP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP46087
EntryNameNOP2_HUMAN
FullNameProbable 28S rRNA (cytosine(4447)-C(5))-methyltransferase
TaxID9606
Evidenceevidence at protein level
Length812
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesNOP2

GO terms

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GOName
GO:0000027 ribosomal large subunit assembly
GO:0000470 maturation of LSU-rRNA
GO:0001510 RNA methylation
GO:0003723 RNA binding
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008284 positive regulation of cell population proliferation
GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity
GO:0070475 rRNA base methylation
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001678 SAM-dependent methyltransferase RsmB/NOP2-typeDomainDomain
IPR011023 Nop2pDomainDomain
IPR012586 P120R repeatRepeatRepeat
IPR018314 Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved siteSiteConserved site
IPR023267 RNA (C5-cytosine) methyltransferaseFamilyFamily
IPR023273 RNA (C5-cytosine) methyltransferase, NOP2FamilyFamily
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily
IPR031341 Ribosomal RNA small subunit methyltransferase F, N-terminalDomainDomain

Diseases

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