Entity Details

Primary name MECOM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ03112
EntryNameMECOM_HUMAN
FullNameHistone-lysine N-methyltransferase MECOM
TaxID9606
Evidenceevidence at protein level
Length1230
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesMECOM

GO terms

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GOName
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0016607 nuclear speck
GO:0030154 cell differentiation
GO:0042803 protein homodimerization activity
GO:0043069 negative regulation of programmed cell death
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046329 negative regulation of JNK cascade
GO:0046872 metal ion binding
GO:0046974 histone methyltransferase activity (H3-K9 specific)
GO:0051726 regulation of cell cycle
GO:0070828 heterochromatin organization
GO:0071425 hematopoietic stem cell proliferation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR001214 SET domainDomainDomain
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily
IPR044411 PRDM3, PR/SET domainDomainDomain

Diseases

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Disease IDSourceNameDescription
616738 OMIMRadioulnar synostosis with amegakaryocytic thrombocytopenia 2 (RUSAT2)An autosomal dominant disease characterized by proximal fusion of the radius and ulna resulting in extremely limited pronation and supination of the forearm, and congenital thrombocytopenia that progresses to pancytopenia. The disease is caused by variants affecting the gene represented in this entry.

Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
MECOM_HUMANUXT_HUMANIntAct17635584 details
MECOM_HUMANANM1_HUMANBioGRID, MINT23455924 details
MECOM_HUMANP55G_HUMANBioGRID, IntAct25814554 details
MECOM_HUMANRBG10_HUMANBioGRID, IntAct25814554 details
MECOM_HUMANRBG1L_HUMANBioGRID, IntAct25814554 details
MECOM_HUMANCLIC3_HUMANBioGRID, IntAct32296183 details
MECOM_HUMANCTBP1_HUMANBioGRID, HPRD, IntAct11313276 11328817 11568182 26186194 28514442 30462309 details
MECOM_HUMANRBBP4_HUMANBioGRID, MINT30462309 details
MECOM_HUMANAPBB2_HUMANIntAct32814053 details
MECOM_HUMANHSPB1_HUMANBioGRID, IntAct30462309 32814053 details
MECOM_HUMANWFS1_HUMANIntAct32814053 details
MECOM_HUMANKIF1B_HUMANIntAct32814053 details
MECOM_HUMANRNF11_HUMANIntAct32814053 details
MECOM_HUMANHDAC1_HUMANBioGRID, HPRD11552981 11568182 30462309 details
MECOM_HUMANCBP_HUMANBioGRID, HPRD11568182 details
MECOM_HUMANKAT2B_HUMANBioGRID, HPRD11568182 20363750 details
MECOM_HUMANSMAD3_HUMANBioGRID, HPRD15849193 9665135 details
MECOM_HUMANMBD3_HUMANBioGRID18500823 30462309 details
MECOM_HUMANSUV91_HUMANBioGRID18619962 18655152 details
MECOM_HUMANSMAD1_HUMANBioGRID15849193 details
MECOM_HUMANSMAD2_HUMANBioGRID15849193 details
MECOM_HUMANSMAD4_HUMANBioGRID15849193 details
MECOM_HUMANUBC9_HUMANBioGRID23770046 details
MECOM_HUMANHIC1_HUMANBioGRID24907396 details
MECOM_HUMANMECOM_HUMANBioGRID, HPRD14603251 30462309 details
MECOM_HUMANSIR1_HUMANBioGRID, UniProt21555002 details
MECOM_HUMANFOS_HUMANDIP22308434 details
MECOM_HUMANHDAC4_HUMANBioGRID, HPRD11568182 details
MECOM_HUMANEHMT2_HUMANBioGRID18619962 details
MECOM_HUMANPIAS4_HUMANBioGRID23770046 details
MECOM_HUMANCTBP2_HUMANBioGRID, HPRD30462309 9724649 details
MECOM_HUMANMTA1_HUMANBioGRID30462309 details
MECOM_HUMANHDAC2_HUMANBioGRID30462309 details
MECOM_HUMANSMG7_HUMANBioGRID29395067 details