Entity Details

Primary name ATR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13535
EntryNameATR_HUMAN
FullNameSerine/threonine-protein kinase ATR
TaxID9606
Evidenceevidence at protein level
Length2644
SequenceStatuscomplete
DateCreated2005-03-29
DateModified2021-06-02

Ontological Relatives

GenesATR

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000723 telomere maintenance
GO:0003677 DNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005794 Golgi apparatus
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007275 multicellular organism development
GO:0008156 negative regulation of DNA replication
GO:0016605 PML body
GO:0018105 peptidyl-serine phosphorylation
GO:0031297 replication fork processing
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0032405 MutLalpha complex binding
GO:0032407 MutSalpha complex binding
GO:0034644 cellular response to UV
GO:0036297 interstrand cross-link repair
GO:0042493 response to drug
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777 protein autophosphorylation
GO:0070198 protein localization to chromosome, telomeric region
GO:0071480 cellular response to gamma radiation
GO:0090399 replicative senescence
GO:0097694 establishment of RNA localization to telomere
GO:0097695 establishment of protein-containing complex localization to telomere
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900034 regulation of cellular response to heat
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1904884 positive regulation of telomerase catalytic core complex assembly

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR003151 PIK-related kinase, FATDomainDomain
IPR003152 FATC domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR012993 UME domainDomainDomain
IPR014009 PIK-related kinaseDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR021133 HEAT, type 2RepeatRepeat
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
210600 OMIMSeckel syndrome 1 (SCKL1)A rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation. The disease is caused by variants affecting the gene represented in this entry.
614564 OMIMCutaneous telangiectasia and cancer syndrome, familial (FCTCS)A disease characterized by cutaneous telangiectases in infancy with patchy alopecia over areas of affected skin, thinning of the lateral eyebrows, and mild dental and nail anomalies. Affected individuals are at increased risk of developing oropharyngeal cancer, and other malignancies have been reported as well. The disease is caused by variants affecting the gene represented in this entry.

Interactions

93 interactions

InteractorPartnerSourcesPublicationsLink
ATR_HUMANP53_HUMANBioGRID, HPRD, IntAct10435622 10608806 10673501 10747897 10951572 11459832 11551930 11709713 11883897 15159397 15775976 16293623 20798688 9765199 details
ATR_HUMANCREB1_HUMANBioGRID, IntAct16293623 details
ATR_HUMANAATF_HUMANHPRD, IntAct17157788 details
ATR_HUMANCDC5L_HUMANBioGRID, MINT19633697 details
ATR_HUMANATRIP_HUMANBioGRID, DIP, HPRD, IntAct11721054 14657349 14724280 15210935 15451423 15758953 17384638 17686975 18162465 18283122 18344416 19097996 19889979 20616048 20847938 21285353 23144622 28514442 details
ATR_HUMANCHK1_HUMANBioGRID, DIP, HPRD10608806 11252893 11390642 15775976 17686975 19330022 21566061 32357935 details
ATR_HUMANBRCA1_HUMANBioGRID, HPRD, UniProt10608806 11016625 11114888 11278964 17478428 23901102 29656893 details
ATR_HUMANABL1_HUMANBioGRID10608806 20798688 details
ATR_HUMANAP1B1_HUMANBioGRID10608806 details
ATR_HUMANARHG1_HUMANBioGRID10608806 details
ATR_HUMANATM_HUMANBioGRID10608806 17124492 details
ATR_HUMANATR_HUMANBioGRID10608806 22258451 28191891 details
ATR_HUMANBRCA2_HUMANBioGRID10608806 details
ATR_HUMANE4F1_HUMANBioGRID10608806 details
ATR_HUMANDNLI4_HUMANBioGRID10608806 details
ATR_HUMANMRE11_HUMANBioGRID10608806 details
ATR_HUMANNBN_HUMANBioGRID, HPRD10608806 15758953 23368512 details
ATR_HUMANPA2G4_HUMANBioGRID10608806 details
ATR_HUMANPK3CA_HUMANBioGRID10608806 details
ATR_HUMANDPOD1_HUMANBioGRID10608806 details
ATR_HUMANRAD17_HUMANBioGRID, HPRD10608806 11418864 14724280 20424596 details
ATR_HUMANRFA1_HUMANBioGRID10608806 18162465 24332808 details
ATR_HUMANWRN_HUMANBioGRID10608806 17118963 22159421 details
ATR_HUMANMCM2_HUMANBioGRID15210935 details
ATR_HUMANMSH2_HUMANBioGRID, HPRD14657349 21285353 33005030 details
ATR_HUMANRHEB_HUMANBioGRID, HPRD15854902 details
ATR_HUMANH2AX_HUMANBioGRID19805520 22184063 details
ATR_HUMANCDC6_HUMANBioGRID20048340 details
ATR_HUMANFANCA_HUMANBioGRID19109555 details
ATR_HUMANRFA2_HUMANBioGRID15929725 17035231 24332808 details
ATR_HUMANCHK2_HUMANBioGRID, HPRD10973490 11715017 12024051 12493754 17035231 9857181 details
ATR_HUMANMCPH1_HUMANBioGRID16872911 25301947 details
ATR_HUMANRENT1_HUMANBioGRID16488880 details
ATR_HUMANCE164_HUMANBioGRID18283122 details
ATR_HUMANDPOLN_HUMANBioGRID21242293 details
ATR_HUMANBLM_HUMANBioGRID14729972 details
ATR_HUMANEP300_HUMANBioGRID17272271 details
ATR_HUMANFACD2_HUMANBioGRID14988723 16943440 22258451 details
ATR_HUMANE2F1_HUMANBioGRID, HPRD11459832 details
ATR_HUMANXRCC5_HUMANBioGRID, HPRD15758953 details
ATR_HUMANDCAF1_HUMANBioGRID22184063 details
ATR_HUMANDCR1C_HUMANBioGRID15456891 details
ATR_HUMANDTL_HUMANBioGRID23029527 details
ATR_HUMANXPA_HUMANBioGRID, HPRD16540648 23178497 details
ATR_HUMANCDN2C_HUMANBioGRID15680327 details
ATR_HUMANP2R3A_HUMANBioGRID10608806 details
ATR_HUMANRASF1_HUMANBioGRID10608806 details
ATR_HUMANAP3B1_HUMANBioGRID10608806 details
ATR_HUMANETV1_HUMANBioGRID23284306 details
ATR_HUMANIKKA_HUMANBioGRID21466675 details
ATR_HUMANFANCI_HUMANBioGRID22258451 details
ATR_HUMANVGFR1_HUMANHPRD10749680 details
ATR_HUMANVGFR2_HUMANHPRD10749680 details
ATR_HUMANTELO2_HUMANBioGRID, IntAct, UniProt17384638 18160036 19097996 20427287 20801936 details
ATR_HUMANNEMO_HUMANBioGRID, MINT18583959 details
ATR_HUMANCDK9_HUMANBioGRID, MINT20930849 details
ATR_HUMANTTI1_HUMANBioGRID, UniProt20427287 20810650 details
ATR_HUMANCINP_HUMANBioGRID, DIP19889979 details
ATR_HUMANMCM7_HUMANBioGRID15210935 details
ATR_HUMANCLSPN_HUMANBioGRID, HPRD12766152 details
ATR_HUMANCHD4_HUMANBioGRID, HPRD10545197 details
ATR_HUMANHDAC2_HUMANBioGRID10545197 details
ATR_HUMANHDAC1_HUMANBioGRID10545197 details
ATR_HUMANMTA1_HUMANBioGRID10545197 20427275 details
ATR_HUMANMTA2_HUMANBioGRID10545197 details
ATR_HUMANXPC_HUMANBioGRID19805520 23422745 details
ATR_HUMANPMS1_HUMANBioGRID17148452 details
ATR_HUMANMSH6_HUMANBioGRID20029092 details
ATR_HUMANTOPB1_HUMANBioGRID19097996 28439015 details
ATR_HUMANFAP24_HUMANBioGRID18995830 details
ATR_HUMANSMC1A_HUMANBioGRID15640246 details
ATR_HUMANRAD1_HUMANBioGRID18162465 details
ATR_HUMANHUS1_HUMANBioGRID18162465 details
ATR_HUMANRAD9A_HUMANBioGRID18162465 details
ATR_HUMANSNIP1_HUMANBioGRID17260016 details
ATR_HUMANNCOA2_HUMANBioGRID16051665 details
ATR_HUMANHS90A_HUMANBioGRID21566061 details
ATR_HUMANHSP74_HUMANBioGRID21566061 details
ATR_HUMANSOCS1_HUMANBioGRID20005840 29991678 details
ATR_HUMANCDN2A_HUMANBioGRID15775976 details
ATR_HUMANARF_HUMANBioGRID15775976 details
ATR_HUMANEGFR_HUMANBioGRID23956138 details
ATR_HUMANUBP20_HUMANBioGRID25326330 details
ATR_HUMANAIRE_HUMANBioGRID27365398 details
ATR_HUMANFBX32_HUMANBioGRID29805624 details
ATR_HUMANPALB2_HUMANBioGRID28089683 details
ATR_HUMANETAA1_HUMANBioGRID27723720 details
ATR_HUMANINT3_HUMANBioGRID25916848 details
ATR_HUMANSPSB1_HUMANBioGRID25916848 details
ATR_HUMANTBG1_HUMANBioGRID17171639 details
ATR_HUMANSYCP3_HUMANBioGRID31043422 details
ATR_HUMANLRC31_HUMANBioGRID33005030 details
ATR_HUMANMCA3_HUMANHPRD15680327 details