Entity Details
| Primary name |
MF2L2_HUMAN |
| Entity type |
UniProt |
| Source |
Source Link |
Details
| Accession | Q86YR7 |
| EntryName | MF2L2_HUMAN |
| FullName | Probable guanine nucleotide exchange factor MCF2L2 |
| TaxID | 9606 |
| Evidence | evidence at transcript level |
| Length | 1114 |
| SequenceStatus | complete |
| DateCreated | 2008-05-20 |
| DateModified | 2021-06-02 |
GO terms
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| GO | Name |
| GO:0005085 | guanyl-nucleotide exchange factor activity |
Subcellular Location
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Domains
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| Domain | Name | Category | Type |
| IPR000219 | Dbl homology (DH) domain | Domain | Domain |
| IPR001251 | CRAL-TRIO lipid binding domain | Domain | Domain |
| IPR001849 | Pleckstrin homology domain | Domain | Domain |
| IPR011993 | PH-like domain superfamily | Family | Homologous superfamily |
| IPR018159 | Spectrin/alpha-actinin | Repeat | Repeat |
| IPR035899 | Dbl homology (DH) domain superfamily | Family | Homologous superfamily |
| IPR036865 | CRAL-TRIO lipid binding domain superfamily | Family | Homologous superfamily |
Diseases
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| Disease ID | Source | Name | Description |
| 125853 | OMIM | Diabetes mellitus, non-insulin-dependent (NIDDM) | A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Disease susceptibility may be associated with variants affecting the gene represented in this entry. |
Interactions
2 interactions