Entity Details

Primary name MEIS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00470
EntryNameMEIS1_HUMAN
FullNameHomeobox protein Meis1
TaxID9606
Evidenceevidence at protein level
Length390
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesMEIS1

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001525 angiogenesis
GO:0001654 eye development
GO:0002089 lens morphogenesis in camera-type eye
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007420 brain development
GO:0007626 locomotory behavior
GO:0008284 positive regulation of cell population proliferation
GO:0009880 embryonic pattern specification
GO:0009887 animal organ morphogenesis
GO:0030097 hemopoiesis
GO:0035855 megakaryocyte development
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060216 definitive hemopoiesis

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR008422 Homeobox KN domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR032453 Homeobox protein PKNOX/Meis, N-terminalDomainDomain

Diseases

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Disease IDSourceNameDescription
612853 OMIMRestless legs syndrome 7 (RLS7)A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep. Disease susceptibility may be associated with variants affecting the gene represented in this entry.