Entity Details

Primary name NICA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92542
EntryNameNICA_HUMAN
FullNameNicastrin
TaxID9606
Evidenceevidence at protein level
Length709
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesNCSTN

GO terms

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GOName
GO:0002262 myeloid cell homeostasis
GO:0004175 endopeptidase activity
GO:0005739 mitochondrion
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0007212 dopamine receptor signaling pathway
GO:0007215 glutamate receptor signaling pathway
GO:0007220 Notch receptor processing
GO:0007611 learning or memory
GO:0008021 synaptic vesicle
GO:0010008 endosome membrane
GO:0010950 positive regulation of endopeptidase activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0021549 cerebellum development
GO:0022010 central nervous system myelination
GO:0030534 adult behavior
GO:0030674 protein-macromolecule adaptor activity
GO:0031293 membrane protein intracellular domain proteolysis
GO:0034205 amyloid-beta formation
GO:0035333 Notch receptor processing, ligand-dependent
GO:0035577 azurophil granule membrane
GO:0042098 T cell proliferation
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0042982 amyloid precursor protein metabolic process
GO:0042983 amyloid precursor protein biosynthetic process
GO:0042986 positive regulation of amyloid precursor protein biosynthetic process
GO:0042987 amyloid precursor protein catabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043312 neutrophil degranulation
GO:0048013 ephrin receptor signaling pathway
GO:0050673 epithelial cell proliferation
GO:0051117 ATPase binding
GO:0051402 neuron apoptotic process
GO:0070062 extracellular exosome
GO:0070765 gamma-secretase complex
GO:0070851 growth factor receptor binding
GO:0071277 cellular response to calcium ion
GO:0099056 integral component of presynaptic membrane
GO:1900271 regulation of long-term synaptic potentiation
GO:1990000 amyloid fibril formation
GO:1990926 short-term synaptic potentiation

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle membrane
Melanosome
Membrane

Domains

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DomainNameCategoryType
IPR008710 NicastrinFamilyFamily
IPR041084 Nicastrin, small lobeDomainDomain

Diseases

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Disease IDSourceNameDescription
142690 OMIMAcne inversa, familial, 1 (ACNINV1)A chronic relapsing inflammatory disease of the hair follicles characterized by recurrent draining sinuses, painful skin abscesses, and disfiguring scars. Manifestations typically appear after puberty. The disease is caused by variants affecting the gene represented in this entry.