Entity Details

Primary name OTUB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96DC9
EntryNameOTUB2_HUMAN
FullNameUbiquitin thioesterase OTUB2
TaxID9606
Evidenceevidence at protein level
Length234
SequenceStatuscomplete
DateCreated2004-03-01
DateModified2021-06-02

Ontological Relatives

GenesOTUB2

GO terms

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GOName
GO:0004843 thiol-dependent deubiquitinase
GO:0005634 nucleus
GO:0016579 protein deubiquitination
GO:0019784 NEDD8-specific protease activity
GO:0035871 protein K11-linked deubiquitination
GO:0043130 ubiquitin binding
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
GO:1901315 negative regulation of histone H2A K63-linked ubiquitination
GO:2000780 negative regulation of double-strand break repair

Subcellular Location

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Domains

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DomainNameCategoryType
IPR003323 OTU domainDomainDomain
IPR016615 Ubiquitin thioesterase OtubainFamilyFamily
IPR019400 Peptidase C65, otubainFamilyFamily
IPR030299 Ubiquitin thioesterase OTUB2FamilyFamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily
IPR042467 Peptidase C65, otubain, subdomain 2FamilyHomologous superfamily
IPR042468 Peptidase C65, otubain, subdomain 1FamilyHomologous superfamily

Diseases

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Interactions

55 interactions

InteractorPartnerSourcesPublicationsLink
OTUB2_HUMANMAGAB_HUMANBioGRID, HPRD, IntAct16189514 details
OTUB2_HUMANATX3_HUMANBioGRID, IntAct19615732 32814053 details
OTUB2_HUMANTRI18_HUMANBioGRID, IntAct25416956 details
OTUB2_HUMANREL_HUMANBioGRID, IntAct25416956 32296183 details
OTUB2_HUMANASPP2_HUMANBioGRID, IntAct25416956 32296183 details
OTUB2_HUMANCPSF6_HUMANBioGRID, IntAct25416956 details
OTUB2_HUMANSIAH1_HUMANBioGRID, IntAct25416956 details
OTUB2_HUMANF168A_HUMANBioGRID, IntAct21516116 25416956 31515488 32296183 details
OTUB2_HUMANARRD3_HUMANBioGRID, IntAct25416956 32296183 details
OTUB2_HUMANLZTS2_HUMANBioGRID, IntAct25416956 details
OTUB2_HUMANTRI54_HUMANBioGRID, IntAct22626734 25416956 31515488 details
OTUB2_HUMANTRIM1_HUMANBioGRID, IntAct25416956 details
OTUB2_HUMANSDCB1_HUMANMINT26787460 details
OTUB2_HUMANTRAF6_HUMANBioGRID, IntAct19996094 23105109 32296183 details
OTUB2_HUMANTRIM8_HUMANBioGRID, IntAct23105109 32296183 details
OTUB2_HUMANDAZP2_HUMANBioGRID, IntAct32296183 details
OTUB2_HUMANMKRN1_HUMANBioGRID, IntAct32296183 details
OTUB2_HUMANPMEPA_HUMANBioGRID, IntAct32296183 details
OTUB2_HUMANSPART_HUMANBioGRID, IntAct32296183 details
OTUB2_HUMANPHLA2_HUMANBioGRID, IntAct32296183 details
OTUB2_HUMANCDIP1_HUMANBioGRID, IntAct32296183 details
OTUB2_HUMANPKHB2_HUMANBioGRID, IntAct32296183 details
OTUB2_HUMANUBE2N_HUMANBioGRID20725033 details
OTUB2_HUMANRFFL_HUMANBioGRID22626734 details
OTUB2_HUMANPJA1_HUMANBioGRID22626734 details
OTUB2_HUMANTRI63_HUMANBioGRID22626734 details
OTUB2_HUMANTRI55_HUMANBioGRID22626734 details
OTUB2_HUMANUBP21_HUMANBioGRID22626734 details
OTUB2_HUMANUBP28_HUMANBioGRID22626734 details
OTUB2_HUMANA4_HUMANBioGRID21832049 details
OTUB2_HUMANTRI27_HUMANBioGRID23105109 details
OTUB2_HUMANTRI25_HUMANBioGRID23105109 details
OTUB2_HUMANTRI26_HUMANBioGRID23105109 details
OTUB2_HUMANHOIL1_HUMANBioGRID23105109 details
OTUB2_HUMANTRIM2_HUMANBioGRID23105109 details
OTUB2_HUMANRN126_HUMANBioGRID23105109 details
OTUB2_HUMANTRI39_HUMANBioGRID23105109 details
OTUB2_HUMANTRIM5_HUMANBioGRID23105109 details
OTUB2_HUMANUBC_HUMANBioGRID18954305 23827681 25590432 29576527 31494268 details
OTUB2_HUMANK1H1_HUMANBioGRID25416956 details
OTUB2_HUMANTRIP6_HUMANBioGRID25416956 details
OTUB2_HUMANK1C40_HUMANBioGRID25416956 details
OTUB2_HUMANGLI2_HUMANBioGRID30241937 details
OTUB2_HUMANU2AF2_HUMANBioGRID30662561 details
OTUB2_HUMANTRAF3_HUMANBioGRID19996094 details
OTUB2_HUMANMAVS_HUMANBioGRID19996094 details
OTUB2_HUMANNMRL1_HUMANBioGRID24763515 31796584 details
OTUB2_HUMANCTNB1_HUMANBioGRID30323974 details
OTUB2_HUMANYAP1_HUMANBioGRID30472188 details
OTUB2_HUMANWWTR1_HUMANBioGRID30472188 details
OTUB2_HUMANPIAS3_HUMANBioGRID30472188 details
OTUB2_HUMANSENP1_HUMANBioGRID30472188 details
OTUB2_HUMANSUMO3_HUMANBioGRID30472188 details
OTUB2_HUMANNR4A1_HUMANBioGRID30905540 details
OTUB2_HUMANSNAI1_HUMANBioGRID31911859 details