Entity Details

Primary name CDC6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99741
EntryNameCDC6_HUMAN
FullNameCell division control protein 6 homolog
TaxID9606
Evidenceevidence at protein level
Length560
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesCDC6

GO terms

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GOName
GO:0000076 DNA replication checkpoint signaling
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000166 nucleotide binding
GO:0000278 mitotic cell cycle
GO:0000922 spindle pole
GO:0003688 DNA replication origin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0007089 traversing start control point of mitotic cell cycle
GO:0008156 negative regulation of DNA replication
GO:0008285 negative regulation of cell population proliferation
GO:0019900 kinase binding
GO:0030071 regulation of mitotic metaphase/anaphase transition
GO:0032467 positive regulation of cytokinesis
GO:0033314 mitotic DNA replication checkpoint signaling
GO:0036388 pre-replicative complex assembly
GO:0045171 intercellular bridge
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0048146 positive regulation of fibroblast proliferation
GO:0051233 spindle midzone
GO:0051301 cell division
GO:0051984 positive regulation of chromosome segregation
GO:0072686 mitotic spindle
GO:1904117 cellular response to vasopressin
GO:1904385 cellular response to angiotensin

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR015163 Cdc6, C-terminalDomainDomain
IPR016314 Cell division protein Cdc6/18FamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR041083 AAA lid domainDomainDomain

Diseases

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Disease IDSourceNameDescription
613805 OMIMMeier-Gorlin syndrome 5 (MGORS5)A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. The disease is caused by variants affecting the gene represented in this entry.

Interactions

53 interactions

InteractorPartnerSourcesPublicationsLink
CDC6_HUMANORC1_HUMANBioGRID, HPRD, IntAct12614612 12912926 15232106 9566895 details
CDC6_HUMANORC2_HUMANBioGRID, HPRD, IntAct11046155 12614612 15232106 details
CDC6_HUMANMCM10_HUMANBioGRID, HPRD, IntAct15232106 details
CDC6_HUMANMCM2_HUMANBioGRID, HPRD, IntAct15232106 23405012 details
CDC6_HUMANORC5_HUMANBioGRID, HPRD, IntAct15232106 details
CDC6_HUMANORC3_HUMANBioGRID, HPRD, IntAct15232106 details
CDC6_HUMANORC6_HUMANBioGRID, HPRD, IntAct15232106 details
CDC6_HUMANCDN2A_HUMANBioGRID, IntAct15232106 details
CDC6_HUMANCDN1A_HUMANBioGRID, HPRD, IntAct15232106 25241761 details
CDC6_HUMANCDT1_HUMANBioGRID, HPRD, IntAct14672932 15232106 18162579 25990725 details
CDC6_HUMANMCM3_HUMANBioGRID, HPRD, IntAct10464337 11046155 15232106 details
CDC6_HUMANUBE2K_HUMANBioGRID, IntAct21988832 details
CDC6_HUMANB3GL1_HUMANBioGRID, IntAct21988832 details
CDC6_HUMANCDK4_HUMANBioGRID, IntAct22094256 details
CDC6_HUMANCDK6_HUMANBioGRID, IntAct22094256 details
CDC6_HUMANMCM7_HUMANBioGRID, HPRD, IntAct10464337 12614612 23397142 23405012 25990725 details
CDC6_HUMANCDK1_HUMANBioGRID, DIP10339564 21041660 details
CDC6_HUMANPLK1_HUMANDIP21041660 details
CDC6_HUMANP2R3B_HUMANBioGRID, HPRD10629059 details
CDC6_HUMANKPSH1_HUMANBioGRID, HPRD9889196 details
CDC6_HUMANCCNA2_HUMANBioGRID, HPRD10339564 9566895 9889196 details
CDC6_HUMANMYC_HUMANBioGRID, HPRD10899308 details
CDC6_HUMANCDK2_HUMANBioGRID, HPRD10339564 9566895 9889196 details
CDC6_HUMANPCNA_HUMANBioGRID, HPRD9566895 details
CDC6_HUMANP2R3A_HUMANBioGRID, HPRD10629059 18397887 details
CDC6_HUMANHUWE1_HUMANBioGRID17567951 details
CDC6_HUMANTERF1_HUMANBioGRID18761675 details
CDC6_HUMANATR_HUMANBioGRID20048340 details
CDC6_HUMANATM_HUMANBioGRID20048340 details
CDC6_HUMANATRIP_HUMANBioGRID20048340 details
CDC6_HUMANKAT7_HUMANBioGRID16428461 details
CDC6_HUMANFZR1_HUMANBioGRID10995389 14701726 21768287 details
CDC6_HUMANCDC20_HUMANBioGRID14701726 details
CDC6_HUMANARF_HUMANBioGRID, HPRD15232106 details
CDC6_HUMANCCNE1_HUMANBioGRID10339564 details
CDC6_HUMANCCNB1_HUMANBioGRID10339564 details
CDC6_HUMANCC14A_HUMANBioGRID22117071 details
CDC6_HUMANUBR1_HUMANBioGRID8505328 details
CDC6_HUMANCCNF_HUMANBioGRID26818844 details
CDC6_HUMANGRWD1_HUMANBioGRID25990725 29991511 details
CDC6_HUMANSQSTM_HUMANBioGRID29507222 details
CDC6_HUMANOGT1_HUMANBioGRID32994395 details
CDC6_HUMANUBB_HUMANIntAct10995389 details
CDC6_HUMANE2F1_HUMANIntAct23397142 details
CDC6_HUMANMCM6_HUMANIntAct23397142 details
CDC6_HUMANTTC4_HUMANIntAct18320024 details
CDC6_HUMANAKP8L_HUMANBioGRID, HPRD12538639 details
CDC6_HUMANMCM8_HUMANBioGRID15684404 details
CDC6_HUMANBMI1_HUMANBioGRID19462008 details
CDC6_HUMANCCL2_HUMANBioGRID21383955 details
CDC6_HUMANHIF1A_HUMANBioGRID23405012 details
CDC6_HUMANMCM5_HUMANBioGRID23405012 details
CDC6_HUMANRS27A_HUMANHPRD10995389 details