Entity Details

Primary name PINK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BXM7
EntryNamePINK1_HUMAN
FullNameSerine/threonine-protein kinase PINK1, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length581
SequenceStatuscomplete
DateCreated2004-06-07
DateModified2021-06-02

Ontological Relatives

GenesPINK1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0000422 autophagy of mitochondrion
GO:0000785 chromatin
GO:0001934 positive regulation of protein phosphorylation
GO:0002020 protease binding
GO:0002082 regulation of oxidative phosphorylation
GO:0002931 response to ischemia
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006468 protein phosphorylation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006979 response to oxidative stress
GO:0007005 mitochondrion organization
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0010629 negative regulation of gene expression
GO:0010821 regulation of mitochondrion organization
GO:0010857 calcium-dependent protein kinase activity
GO:0010952 positive regulation of peptidase activity
GO:0016020 membrane
GO:0016236 macroautophagy
GO:0016239 positive regulation of macroautophagy
GO:0016242 negative regulation of macroautophagy
GO:0016301 kinase activity
GO:0016504 peptidase activator activity
GO:0016567 protein ubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0022904 respiratory electron transport chain
GO:0030424 axon
GO:0030426 growth cone
GO:0031307 integral component of mitochondrial outer membrane
GO:0031396 regulation of protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0032148 activation of protein kinase B activity
GO:0032226 positive regulation of synaptic transmission, dopaminergic
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033603 positive regulation of dopamine secretion
GO:0034599 cellular response to oxidative stress
GO:0035307 positive regulation of protein dephosphorylation
GO:0035556 intracellular signal transduction
GO:0036289 peptidyl-serine autophosphorylation
GO:0038203 TORC2 signaling
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043254 regulation of protein-containing complex assembly
GO:0043422 protein kinase B binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0044297 cell body
GO:0044877 protein-containing complex binding
GO:0045727 positive regulation of translation
GO:0046329 negative regulation of JNK cascade
GO:0048471 perinuclear region of cytoplasm
GO:0050821 protein stabilization
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0051881 regulation of mitochondrial membrane potential
GO:0051897 positive regulation of protein kinase B signaling
GO:0055131 C3HC4-type RING finger domain binding
GO:0061136 regulation of proteasomal protein catabolic process
GO:0071456 cellular response to hypoxia
GO:0072655 establishment of protein localization to mitochondrion
GO:0072656 maintenance of protein location in mitochondrion
GO:0090141 positive regulation of mitochondrial fission
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090258 negative regulation of mitochondrial fission
GO:0097237 cellular response to toxic substance
GO:0097413 Lewy body
GO:0097449 astrocyte projection
GO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization
GO:0099074 mitochondrion to lysosome transport
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900407 regulation of cellular response to oxidative stress
GO:1901727 positive regulation of histone deacetylase activity
GO:1902803 regulation of synaptic vesicle transport
GO:1902902 negative regulation of autophagosome assembly
GO:1902958 positive regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903146 regulation of autophagy of mitochondrion
GO:1903147 negative regulation of autophagy of mitochondrion
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1903204 negative regulation of oxidative stress-induced neuron death
GO:1903214 regulation of protein targeting to mitochondrion
GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO:1903384 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
GO:1903852 positive regulation of cristae formation
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1904544 positive regulation of free ubiquitin chain polymerization
GO:1904783 positive regulation of NMDA glutamate receptor activity
GO:1904841 TORC2 complex binding
GO:1904881 cellular response to hydrogen sulfide
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2001171 positive regulation of ATP biosynthetic process
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion inner membrane
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR040110 PINK1, protein kinase domainDomainDomain

Diseases

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Disease IDSourceNameDescription
605909 OMIMParkinson disease 6 (PARK6)An early-onset form of Parkinson disease, a neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep. PARK6 pathogenesis involves respiratory complex I deficiency causing mitochondrial depolarization and dysfunction. Inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.
168600 OMIMParkinson disease (PARK)A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early-onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Familial forms of the disease usually begin at earlier ages and are associated with atypical clinical features.

Interactions

86 interactions

InteractorPartnerSourcesPublicationsLink
PINK1_HUMANPRKN_HUMANBioGRID, DIP, IntAct, MINT17052189 19167501 19229105 19358826 19880420 19966284 20153330 20798600 22724072 23319602 23670163 23933751 24357652 25474007 25591737 26116755 26162776 27528605 27605430 28945249 29330382 details
PINK1_HUMANFBX7_HUMANBioGRID, IntAct23933751 32493843 details
PINK1_HUMANHSH2D_HUMANBioGRID, IntAct25814554 details
PINK1_HUMANSOCS4_HUMANBioGRID, IntAct25814554 details
PINK1_HUMANSTAT3_HUMANBioGRID, IntAct25814554 details
PINK1_HUMANDP13B_HUMANBioGRID, IntAct25814554 details
PINK1_HUMANTRAP1_HUMANBioGRID, DIP17579517 31300519 details
PINK1_HUMANAP2B1_HUMANIntAct32814053 details
PINK1_HUMANZN366_HUMANIntAct32814053 details
PINK1_HUMANLDH6B_HUMANIntAct32814053 details
PINK1_HUMANVPS29_HUMANIntAct32814053 details
PINK1_HUMANSPAG8_HUMANIntAct32814053 details
PINK1_HUMANPDZ1I_HUMANIntAct32814053 details
PINK1_HUMANIQEC1_HUMANIntAct32814053 details
PINK1_HUMANFEZ2_HUMANIntAct32814053 details
PINK1_HUMANTEAD1_HUMANIntAct32814053 details
PINK1_HUMANPNPH_HUMANIntAct32814053 details
PINK1_HUMANBIRC5_HUMANIntAct32814053 details
PINK1_HUMANA4_HUMANIntAct32814053 details
PINK1_HUMANHD_HUMANIntAct32814053 details
PINK1_HUMANPINK1_HUMANBioGRID, HPRD14607334 22280891 22724072 30783609 31300519 details
PINK1_HUMANPGAM5_HUMANBioGRID21151955 31177901 details
PINK1_HUMANSNCAP_HUMANBioGRID15894486 details
PINK1_HUMANSYUA_HUMANBioGRID19167501 27334109 details
PINK1_HUMANMARK2_HUMANBioGRID22238344 details
PINK1_HUMANPARK7_HUMANBioGRID16632486 19229105 details
PINK1_HUMANUBC12_HUMANBioGRID22388932 details
PINK1_HUMANTRAF6_HUMANBioGRID22643835 23885119 details
PINK1_HUMANM3K7_HUMANBioGRID22643835 details
PINK1_HUMANBAG2_HUMANBioGRID24383081 24513209 details
PINK1_HUMANCRLS1_HUMANBioGRID24703837 details
PINK1_HUMANUBC_HUMANBioGRID24751536 24784582 25474007 25847540 26162776 27605430 28438176 31300519 details
PINK1_HUMANB2CL1_HUMANBioGRID24999239 32088314 details
PINK1_HUMANTGM2_HUMANBioGRID25557247 details
PINK1_HUMANHCD2_HUMANBioGRID25591737 31300519 details
PINK1_HUMANDNM1L_HUMANBioGRID25591737 details
PINK1_HUMANBAG5_HUMANBioGRID24475098 details
PINK1_HUMANKAPCA_HUMANBioGRID30783609 details
PINK1_HUMANNED4L_HUMANBioGRID32140098 details
PINK1_HUMANMLP3B_HUMANBioGRID, MINT20153330 30907226 details
PINK1_HUMANTOM20_HUMANBioGRID, MINT20153330 22280891 23885119 24357652 details
PINK1_HUMANMIRO1_HUMANBioGRID, IntAct22078885 22396657 details
PINK1_HUMANHS90B_HUMANBioGRID, IntAct18003639 22939624 31300519 details
PINK1_HUMANTIM23_HUMANMINT24357652 details
PINK1_HUMANCDC37_HUMANBioGRID, IntAct18003639 18359116 21151955 25036637 28438176 30783609 details
PINK1_HUMANIKBE_HUMANIntAct29128334 details
PINK1_HUMANCLUS_HUMANIntAct31413325 details
PINK1_HUMANPTEN_HUMANBioGRID15717329 details
PINK1_HUMANHS90A_HUMANBioGRID18003639 18359116 21151955 22939624 28438176 31300519 details
PINK1_HUMANHSP74_HUMANBioGRID18359116 21151955 31300519 details
PINK1_HUMANPARL_HUMANBioGRID21355049 details
PINK1_HUMANMLP3A_HUMANBioGRID20153330 details
PINK1_HUMANHTRA2_HUMANBioGRID17906618 details
PINK1_HUMANTOM40_HUMANBioGRID22280891 28438176 30783609 details
PINK1_HUMANTOM70_HUMANBioGRID22280891 details
PINK1_HUMANTOM22_HUMANBioGRID22280891 details
PINK1_HUMANRICTR_HUMANBioGRID21177249 details
PINK1_HUMANSIN1_HUMANBioGRID21177249 details
PINK1_HUMANAKT1_HUMANBioGRID21177249 details
PINK1_HUMANCSN8_HUMANBioGRID22388932 details
PINK1_HUMANTOLIP_HUMANBioGRID23244239 details
PINK1_HUMANIRAK1_HUMANBioGRID23244239 31300519 details
PINK1_HUMANVIME_HUMANBioGRID23885119 31300519 details
PINK1_HUMANSARM1_HUMANBioGRID23885119 details
PINK1_HUMANHS71A_HUMANBioGRID23885119 31300519 details
PINK1_HUMANHS71B_HUMANBioGRID23885119 31300519 details
PINK1_HUMANRBCC1_HUMANBioGRID23885119 details
PINK1_HUMANB2CL2_HUMANBioGRID24999239 details
PINK1_HUMANMCL1_HUMANBioGRID24999239 details
PINK1_HUMANMIRO2_HUMANBioGRID19152501 details
PINK1_HUMANMIC60_HUMANBioGRID19152501 27153535 details
PINK1_HUMANULA1_HUMANBioGRID22388932 details
PINK1_HUMANBNIP3_HUMANBioGRID27528605 details
PINK1_HUMANSAM50_HUMANBioGRID27153535 29874585 details
PINK1_HUMANSQSTM_HUMANBioGRID30907226 31300519 details
PINK1_HUMANULK1_HUMANBioGRID30907226 details
PINK1_HUMANTRAF3_HUMANBioGRID31139191 details
PINK1_HUMANIRF3_HUMANBioGRID31139191 details
PINK1_HUMANYAP1_HUMANBioGRID31139191 details
PINK1_HUMANTERA_HUMANBioGRID30783609 31300519 details
PINK1_HUMANNSF1C_HUMANBioGRID30783609 details
PINK1_HUMANBAG6_HUMANBioGRID31300519 32332095 details
PINK1_HUMANUBE4B_HUMANBioGRID31300519 details
PINK1_HUMANSC61B_HUMANBioGRID31300519 details
PINK1_HUMANAMFR_HUMANBioGRID31300519 details
PINK1_HUMANFKBP5_HUMANBioGRID30734931 details