Entity Details

Primary name 5NT3A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H0P0
EntryName5NT3A_HUMAN
FullNameCytosolic 5'-nucleotidase 3A
TaxID9606
Evidenceevidence at protein level
Length336
SequenceStatuscomplete
DateCreated2005-09-13
DateModified2021-06-02

Ontological Relatives

GenesNT5C3A

GO terms

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GOName
GO:0000166 nucleotide binding
GO:0000215 tRNA 2'-phosphotransferase activity
GO:0000287 magnesium ion binding
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006213 pyrimidine nucleoside metabolic process
GO:0008253 5'-nucleotidase activity
GO:0009117 nucleotide metabolic process
GO:0046135 pyrimidine nucleoside catabolic process
GO:0051607 defense response to virus

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum

Domains

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DomainNameCategoryType
IPR006434 Pyrimidine 5'-nucleotidase, eukaryoticFamilyFamily
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
266120 OMIMP5N deficiency (P5ND)Autosomal recessive condition causing hemolytic anemia characterized by marked basophilic stippling and the accumulation of high concentrations of pyrimidine nucleotides within the erythrocyte. It is implicated in the anemia of lead poisoning and is possibly associated with learning difficulties. The disease is caused by variants affecting the gene represented in this entry.

Interactions

6 interactions