Entity Details

Primary name SPIT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43278
EntryNameSPIT1_HUMAN
FullNameKunitz-type protease inhibitor 1
TaxID9606
Evidenceevidence at protein level
Length529
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesSPINT1

GO terms

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GOName
GO:0001843 neural tube closure
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030198 extracellular matrix organization
GO:0045687 positive regulation of glial cell differentiation
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060674 placenta blood vessel development
GO:0070062 extracellular exosome
GO:0071773 cellular response to BMP stimulus
GO:2000178 negative regulation of neural precursor cell proliferation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR002223 Pancreatic trypsin inhibitor Kunitz domainDomainDomain
IPR011106 Seven cysteines, N-terminalDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR013980 MANSC domainDomainDomain
IPR020901 Proteinase inhibitor I2, Kunitz, conserved siteSiteConserved site
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily
IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamilyFamilyHomologous superfamily
IPR042482 Kunitz-type protease inhibitor 1FamilyFamily

Diseases

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