Entity Details

Primary name OX2R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43614
EntryNameOX2R_HUMAN
FullNameOrexin receptor type 2
TaxID9606
Evidenceevidence at protein level
Length444
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesHCRTR2

GO terms

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GOName
GO:0004930 G protein-coupled receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007631 feeding behavior
GO:0008188 neuropeptide receptor activity
GO:0010840 regulation of circadian sleep/wake cycle, wakefulness
GO:0016499 orexin receptor activity
GO:0017046 peptide hormone binding
GO:0022410 circadian sleep/wake cycle process
GO:0045202 synapse
GO:0051480 regulation of cytosolic calcium ion concentration

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000204 Orexin receptor familyFamilyFamily
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR004060 Orexin receptor 2FamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB09034 SuvorexantDrugbanksmall molecule
DB11951 LemborexantDrugbanksmall molecule

Interactions

3 interactions