Entity Details
| Primary name |
XPP2_HUMAN |
| Entity type |
UniProt |
| Source |
Source Link |
Details
| Accession | O43895 |
| EntryName | XPP2_HUMAN |
| FullName | Xaa-Pro aminopeptidase 2 |
| TaxID | 9606 |
| Evidence | evidence at protein level |
| Length | 674 |
| SequenceStatus | complete |
| DateCreated | 2002-11-15 |
| DateModified | 2021-06-02 |
Subcellular Location
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| Subcellular Location |
| Cell membrane |
Domains
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| Domain | Name | Category | Type |
| IPR000587 | Creatinase, N-terminal | Domain | Domain |
| IPR000994 | Peptidase M24 | Domain | Domain |
| IPR001131 | Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site | Site | Conserved site |
| IPR029149 | Creatinase/Aminopeptidase P/Spt16, N-terminal | Family | Homologous superfamily |
| IPR032416 | Peptidase M24, C-terminal domain | Domain | Domain |
| IPR033740 | Aminopeptidase P | Domain | Domain |
| IPR036005 | Creatinase/aminopeptidase-like | Family | Homologous superfamily |
Diseases
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| Disease ID | Source | Name | Description |
| 300909 | OMIM | Angioedema induced by ACE inhibitors (AEACEI) | A potentially life-threatening side effect of ACE inhibitors that appears in a subset of patients taking these drugs for hypertension and cardiovascular disease treatment. AEACEI is characterized by swelling of the face, lips, tongue, and airway that can lead to suffocation and death if severe. Disease susceptibility is associated with variants affecting the gene represented in this entry. |
Interactions
1 interaction