Entity Details

Primary name GSHR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00390
EntryNameGSHR_HUMAN
FullNameGlutathione reductase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length522
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesGSR

GO terms

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GOName
GO:0004362 glutathione-disulfide reductase (NADPH) activity
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006749 glutathione metabolic process
GO:0009055 electron transfer activity
GO:0009897 external side of plasma membrane
GO:0015949 nucleobase-containing small molecule interconversion
GO:0034599 cellular response to oxidative stress
GO:0045454 cell redox homeostasis
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion

Domains

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DomainNameCategoryType
IPR001100 Pyridine nucleotide-disulphide oxidoreductase, class IFamilyFamily
IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domainDomainDomain
IPR006322 Glutathione reductase, eukaryote/bacterialFamilyFamily
IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active siteSiteActive site
IPR016156 FAD/NAD-linked reductase, dimerisation domain superfamilyFamilyHomologous superfamily
IPR023753 FAD/NAD(P)-binding domainDomainDomain
IPR036188 FAD/NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618660 OMIMHemolytic anemia due to glutathione reductase deficiency (HAGRD)An autosomal recessive disease characterized by hemolytic anemia and impaired activity of glutathione reductase. Patients experience hemolytic anemia in response to oxidative stress or ingestion of fava beans. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule
DB00157 NADHDrugbanksmall molecule
DB00262 CarmustineDrugbanksmall molecule
DB01644 3,6-dihydroxy-xanthene-9-propionic acidDrugbanksmall molecule
DB02153 3-sulfino-L-alanineDrugbanksmall molecule
DB02553 Glutathionylspermidine disulfideDrugbanksmall molecule
DB02895 3-(Prop-2-Ene-1-Sulfinyl)-Propene-1-ThiolDrugbanksmall molecule
DB03147 Flavin adenine dinucleotideDrugbanksmall molecule
DB03310 Glutathione disulfideDrugbanksmall molecule
DB03867 3-nitro-L-tyrosineDrugbanksmall molecule
DB07393 2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINEDrugbanksmall molecule
DB07714 6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACIDDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09110 Coenzyme MSwissprotsmall molecule
DB09130 CopperDrugbanksmall molecule
DB11135 SeleniumSwissprotsmall molecule
DB11590 ThimerosalDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule

Interactions

6 interactions