Entity Details

Primary name ANF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01160
EntryNameANF_HUMAN
FullNameNatriuretic peptides A
TaxID9606
Evidenceevidence at protein level
Length151
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesNPPA

GO terms

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GOName
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0003161 cardiac conduction system development
GO:0003180 aortic valve morphogenesis
GO:0005102 signaling receptor binding
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006182 cGMP biosynthetic process
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006457 protein folding
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007565 female pregnancy
GO:0008217 regulation of blood pressure
GO:0010460 positive regulation of heart rate
GO:0019934 cGMP-mediated signaling
GO:0032991 protein-containing complex
GO:0035994 response to muscle stretch
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042311 vasodilation
GO:0042995 cell projection
GO:0043204 perikaryon
GO:0043508 negative regulation of JUN kinase activity
GO:0051427 hormone receptor binding
GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization
GO:0060452 positive regulation of cardiac muscle contraction
GO:0062023 collagen-containing extracellular matrix
GO:0071855 neuropeptide receptor binding
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1901841 regulation of high voltage-gated calcium channel activity
GO:1902261 positive regulation of delayed rectifier potassium channel activity
GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO:1903766 positive regulation of potassium ion export across plasma membrane
GO:1903779 regulation of cardiac conduction
GO:1990000 amyloid fibril formation

Subcellular Location

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Subcellular Location
Cell projection
Perikaryon
Secreted

Domains

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DomainNameCategoryType
IPR000663 Natriuretic peptideFamilyFamily
IPR002407 Natriuretic peptide, atrial typeFamilyFamily
IPR030480 Natriuretic peptide, conserved siteSiteConserved site

Diseases

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Disease IDSourceNameDescription
612201 OMIMAtrial fibrillation, familial, 6 (ATFB6)A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. The disease is caused by variants affecting the gene represented in this entry.
615745 OMIMAtrial standstill 2 (ATRST2)A rare arrhythmia characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm. The disease is caused by variants affecting the gene represented in this entry.