Entity Details

Primary name LAMB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07942
EntryNameLAMB1_HUMAN
FullNameLaminin subunit beta-1
TaxID9606
Evidenceevidence at protein level
Length1786
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesLAMB1

GO terms

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GOName
GO:0005178 integrin binding
GO:0005198 structural molecule activity
GO:0005201 extracellular matrix structural constituent
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005606 laminin-1 complex
GO:0005607 laminin-2 complex
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0007155 cell adhesion
GO:0009887 animal organ morphogenesis
GO:0009888 tissue development
GO:0016477 cell migration
GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0031175 neuron projection development
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035987 endodermal cell differentiation
GO:0042476 odontogenesis
GO:0043256 laminin complex
GO:0043257 laminin-8 complex
GO:0043259 laminin-10 complex
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0048471 perinuclear region of cytoplasm
GO:0050679 positive regulation of epithelial cell proliferation
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070831 basement membrane assembly

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR002049 Laminin EGF domainDomainDomain
IPR008211 Laminin, N-terminalDomainDomain
IPR013015 Laminin IV type BDomainDomain

Diseases

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Disease IDSourceNameDescription
615191 OMIMLissencephaly 5 (LIS5)An autosomal recessive brain malformation characterized by cobblestone changes in the cortex, more severe in the posterior region, and subcortical band heterotopia. Affected individuals have hydrocephalus, seizures, and severely delayed psychomotor development. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB06245 LanoteplaseDrugbankbiotech