Entity Details

Primary name CY1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08574
EntryNameCY1_HUMAN
FullNameCytochrome c1, heme protein, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length325
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesCYC1

GO terms

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GOName
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005750 mitochondrial respiratory chain complex III
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
GO:0008121 ubiquinol-cytochrome-c reductase activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0020037 heme binding
GO:0033762 response to glucagon
GO:0046872 metal ion binding

Subcellular Location

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Subcellular Location
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR002326 Cytochrome c1FamilyFamily
IPR021157 Cytochrome c1, transmembrane anchor, C-terminalFamilyHomologous superfamily
IPR036909 Cytochrome c-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615453 OMIMMitochondrial complex III deficiency, nuclear 6 (MC3DN6)An autosomal recessive disorder caused by mitochondrial dysfunction. It is characterized by onset in early childhood of episodic acute lactic acidosis, ketoacidosis, and insulin-responsive hyperglycemia, usually associated with infection. Laboratory studies show decreased activity of mitochondrial complex III. Psychomotor development is normal. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB04141 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-TriolDrugbanksmall molecule
DB04799 6-Hydroxy-5-undecyl-4,7-benzothiazoledioneDrugbanksmall molecule
DB07401 AzoxystrobinDrugbanksmall molecule
DB07636 5-Heptyl-6-hydroxy-1,3-benzothiazole-4,7-dioneDrugbanksmall molecule
DB07763 (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONEDrugbanksmall molecule
DB07778 (S)-famoxadoneDrugbanksmall molecule
DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATEDrugbanksmall molecule
DB08453 2-Nonyl-4-quinolinol 1-oxideDrugbanksmall molecule
DB08690 Ubiquinone Q2Drugbanksmall molecule