Entity Details

Primary name AT2A2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16615
EntryNameAT2A2_HUMAN
FullNameSarcoplasmic/endoplasmic reticulum calcium ATPase 2
TaxID9606
Evidenceevidence at protein level
Length1042
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesATP2A2

GO terms

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GOName
GO:0000045 autophagosome assembly
GO:0002026 regulation of the force of heart contraction
GO:0003009 skeletal muscle contraction
GO:0005388 P-type calcium transporter activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0006984 ER-nucleus signaling pathway
GO:0007155 cell adhesion
GO:0008022 protein C-terminus binding
GO:0008544 epidermis development
GO:0008553 P-type proton-exporting transporter activity
GO:0010460 positive regulation of heart rate
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0012506 vesicle membrane
GO:0014801 longitudinal sarcoplasmic reticulum
GO:0014883 transition between fast and slow fiber
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016020 membrane
GO:0016240 autophagosome membrane docking
GO:0016529 sarcoplasmic reticulum
GO:0016887 ATP hydrolysis activity
GO:0019899 enzyme binding
GO:0031095 platelet dense tubular network membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031775 lutropin-choriogonadotropic hormone receptor binding
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032470 positive regulation of endoplasmic reticulum calcium ion concentration
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0033017 sarcoplasmic reticulum membrane
GO:0033292 T-tubule organization
GO:0034220 ion transmembrane transport
GO:0034599 cellular response to oxidative stress
GO:0034605 cellular response to heat
GO:0034976 response to endoplasmic reticulum stress
GO:0044325 transmembrane transporter binding
GO:0044548 S100 protein binding
GO:0045822 negative regulation of heart contraction
GO:0048471 perinuclear region of cytoplasm
GO:0055119 relaxation of cardiac muscle
GO:0061831 apical ectoplasmic specialization
GO:0070296 sarcoplasmic reticulum calcium ion transport
GO:0070588 calcium ion transmembrane transport
GO:0086036 regulation of cardiac muscle cell membrane potential
GO:0086039 P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential
GO:0090534 calcium ion-transporting ATPase complex
GO:0097470 ribbon synapse
GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction
GO:0120025 plasma membrane bounded cell projection
GO:0140056 organelle localization by membrane tethering
GO:1900121 negative regulation of receptor binding
GO:1903233 regulation of calcium ion-dependent exocytosis of neurotransmitter
GO:1903515 calcium ion transport from cytosol to endoplasmic reticulum
GO:1903779 regulation of cardiac conduction
GO:1990036 calcium ion import into sarcoplasmic reticulum
GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Sarcoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR004014 Cation-transporting P-type ATPase, N-terminalDomainDomain
IPR005782 P-type ATPase, subfamily IIA, SERCA-typeFamilyFamily
IPR006068 Cation-transporting P-type ATPase, C-terminalDomainDomain
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

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Disease IDSourceNameDescription
124200 OMIMDarier disease (DD)A skin disorder characterized by warty papules and plaques in seborrheic areas (central trunk, flexures, scalp and forehead), palmoplantar pits and distinctive nail abnormalities. It is due to loss of adhesion between epidermal cells (acantholysis) and abnormal keratinization. Patients with mild disease may have no more than a few scattered keratotic papules or subtle nail changes, whereas those with severe disease are handicapped by widespread malodorous keratotic plaques. Some patients present with hemorrhage into acantholytic vesicles on the palms and dorsal aspects of the fingers which gives rise to black macules. In a few families affected by Darier disease, neuropsychiatric abnormalities such as mild mental retardation, schizophrenia, bipolar disorder and epilepsy have been reported. Stress, UV exposure, heat, sweat, friction and oral contraception exacerbate disease symptoms. Clinical variants of Darier disease include hypertrophic, vesicobullous, hypopigmented, cornifying, zosteriform or linear, acute and comedonal subtypes. Comedonal Darier disease is characterized by the coexistence of acne-like comedonal lesions with typical Darier hyperkeratotic papules on light-exposed areas. At histopathologic level, comedonal Darier disease differs from classic Darier disease in the prominent follicular involvement and the presence of greatly elongated dermal villi. The disease is caused by variants affecting the gene represented in this entry.
101900 OMIMAcrokeratosis verruciformis (AKV)A localized disorder of keratinization, which is inherited as an autosomal dominant trait. Its onset is early in life with multiple flat-topped, flesh-colored papules on the hands and feet, punctate keratoses on the palms and soles, with varying degrees of nail involvement. The histopathology shows a distinctive pattern of epidermal features with hyperkeratosis, hypergranulosis and acanthosis together with papillomatosis. These changes are frequently associated with circumscribed elevations of the epidermis that are said to resemble church spires. There are no features of dyskeratosis or acantholysis, the typical findings in lesions of Darier disease. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01189 DesfluraneDrugbanksmall molecule
DB06157 IstaroximeDrugbanksmall molecule

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
AT2A2_HUMANPAR2_HUMANBioGRID, MINT28298427 details
AT2A2_HUMANCCR4_HUMANBioGRID, MINT28298427 details
AT2A2_HUMANACM5_HUMANBioGRID, MINT28298427 details
AT2A2_HUMANPCNA_HUMANUniProt26030842 details
AT2A2_HUMANS10A1_HUMANBioGRID, HPRD12804600 details
AT2A2_HUMANPPLA_HUMANBioGRID, HPRD10809745 11526231 11854448 12032137 31046837 details
AT2A2_HUMANHGS_HUMANBioGRID19019082 details
AT2A2_HUMANOSTP_HUMANBioGRID22779921 details
AT2A2_HUMANMDM2_HUMANBioGRID24583282 details
AT2A2_HUMANTRI14_HUMANBioGRID29053956 details
AT2A2_HUMANTNR1A_HUMANIntAct14743216 details
AT2A2_HUMANTNR1B_HUMANIntAct14743216 details
AT2A2_HUMANTRADD_HUMANIntAct14743216 details
AT2A2_HUMANTRAF6_HUMANIntAct14743216 details
AT2A2_HUMANEGFR_HUMANBioGRID, IntAct15657067 23956138 24189400 details
AT2A2_HUMANMYC_HUMANBioGRID, IntAct17314511 17353931 29467282 details
AT2A2_HUMANCFTR_HUMANBioGRID, IntAct17110338 25661196 26618866 details
AT2A2_HUMANOPRD_HUMANMINT20528919 details
AT2A2_HUMANTNFA_HUMANIntAct20195357 details
AT2A2_HUMANLRRK2_HUMANBioGRID, IntAct24725412 31046837 details
AT2A2_HUMANMPTX_HUMANIntAct30021884 details
AT2A2_HUMANSARCO_HUMANBioGRID12032137 details
AT2A2_HUMANHDAC5_HUMANBioGRID21081666 details
AT2A2_HUMANTRI13_HUMANBioGRID17314412 details
AT2A2_HUMANHACD3_HUMANBioGRID25036637 details
AT2A2_HUMANSPRTN_HUMANBioGRID23254330 details
AT2A2_HUMANRN126_HUMANBioGRID26508657 details
AT2A2_HUMANNEPRO_HUMANBioGRID26472760 details
AT2A2_HUMANDERL1_HUMANBioGRID28137758 34079125 details
AT2A2_HUMANSIR1_HUMANBioGRID30786847 details
AT2A2_HUMANISG15_HUMANBioGRID33024031 details
AT2A2_HUMANBCL2_HUMANHPRD9788433 details
AT2A2_HUMANAT2A2_HUMANHPRD12670936 details
AT2A2_HUMANIRS1_HUMANHPRD9295312 details
AT2A2_HUMANIRS2_HUMANHPRD9295312 details