Entity Details

Primary name TYPH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19971
EntryNameTYPH_HUMAN
FullNameThymidine phosphorylase
TaxID9606
Evidenceevidence at protein level
Length482
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesTYMP

GO terms

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GOName
GO:0000002 mitochondrial genome maintenance
GO:0001525 angiogenesis
GO:0004645 1,4-alpha-oligoglucan phosphorylase activity
GO:0005829 cytosol
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006213 pyrimidine nucleoside metabolic process
GO:0006935 chemotaxis
GO:0008083 growth factor activity
GO:0009032 thymidine phosphorylase activity
GO:0016154 pyrimidine-nucleoside phosphorylase activity
GO:0030154 cell differentiation
GO:0031641 regulation of myelination
GO:0042803 protein homodimerization activity
GO:0043097 pyrimidine nucleoside salvage
GO:0046074 dTMP catabolic process
GO:0046135 pyrimidine nucleoside catabolic process
GO:0051969 regulation of transmission of nerve impulse
GO:1905333 regulation of gastric motility

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000053 Thymidine/pyrimidine-nucleoside phosphorylaseFamilyFamily
IPR000312 Glycosyl transferase, family 3DomainDomain
IPR013102 Pyrimidine nucleoside phosphorylase, C-terminalDomainDomain
IPR017459 Glycosyl transferase family 3, N-terminal domainDomainDomain
IPR017872 Pyrimidine-nucleoside phosphorylase, conserved siteSiteConserved site
IPR018090 Pyrimidine-nucleoside phosphorylase, bacterial/eukaryoticFamilyFamily
IPR035902 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamilyFamilyHomologous superfamily
IPR036320 Glycosyl transferase family 3, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036566 Pyrimidine nucleoside phosphorylase-like, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
603041 OMIMMitochondrial DNA depletion syndrome 1, MNGIE type (MTDPS1)A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, cachexia, peripheral neuropathy, and myopathy. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00322 FloxuridineDrugbanksmall molecule
DB00369 CidofovirDrugbanksmall molecule
DB00432 TrifluridineDrugbanksmall molecule
DB00544 FluorouracilDrugbanksmall molecule
DB01101 CapecitabineDrugbanksmall molecule
DB06433 TezacitabineDrugbanksmall molecule
DB09343 TipiracilDrugbanksmall molecule

Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
TYPH_HUMANTYPH_HUMANBioGRID, HPRD, IntAct1590793 25416956 details
TYPH_HUMANZMY12_HUMANBioGRID, IntAct32296183 details
TYPH_HUMANMESD_HUMANBioGRID, IntAct32296183 details
TYPH_HUMANERBB2_HUMANBioGRID, IntAct31980649 details
TYPH_HUMANHS90A_HUMANBioGRID22480737 details