Entity Details

Primary name FGFR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21802
EntryNameFGFR2_HUMAN
FullNameFibroblast growth factor receptor 2
TaxID9606
Evidenceevidence at protein level
Length821
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesFGFR2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001657 ureteric bud development
GO:0001701 in utero embryonic development
GO:0001837 epithelial to mesenchymal transition
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0003148 outflow tract septum morphogenesis
GO:0003149 membranous septum morphogenesis
GO:0003416 endochondral bone growth
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005938 cell cortex
GO:0006915 apoptotic process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development
GO:0007409 axonogenesis
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008589 regulation of smoothened signaling pathway
GO:0009791 post-embryonic development
GO:0009880 embryonic pattern specification
GO:0009887 animal organ morphogenesis
GO:0009986 cell surface
GO:0010518 positive regulation of phospholipase activity
GO:0010839 negative regulation of keratinocyte proliferation
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016331 morphogenesis of embryonic epithelium
GO:0017134 fibroblast growth factor binding
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021769 orbitofrontal cortex development
GO:0021847 ventricular zone neuroblast division
GO:0021860 pyramidal neuron development
GO:0022612 gland morphogenesis
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030282 bone mineralization
GO:0030324 lung development
GO:0030855 epithelial cell differentiation
GO:0030901 midbrain development
GO:0030916 otic vesicle formation
GO:0031069 hair follicle morphogenesis
GO:0031410 cytoplasmic vesicle
GO:0032496 response to lipopolysaccharide
GO:0032808 lacrimal gland development
GO:0033674 positive regulation of kinase activity
GO:0033688 regulation of osteoblast proliferation
GO:0035265 organ growth
GO:0035602 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell
GO:0035603 fibroblast growth factor receptor signaling pathway involved in hemopoiesis
GO:0035604 fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
GO:0035607 fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0042060 wound healing
GO:0042472 inner ear morphogenesis
GO:0042476 odontogenesis
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0045165 cell fate commitment
GO:0045471 response to ethanol
GO:0045667 regulation of osteoblast differentiation
GO:0045787 positive regulation of cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046777 protein autophosphorylation
GO:0048286 lung alveolus development
GO:0048333 mesodermal cell differentiation
GO:0048557 embryonic digestive tract morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048565 digestive tract development
GO:0048568 embryonic organ development
GO:0048608 reproductive structure development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048730 epidermis morphogenesis
GO:0048755 branching morphogenesis of a nerve
GO:0048762 mesenchymal cell differentiation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051150 regulation of smooth muscle cell differentiation
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060076 excitatory synapse
GO:0060174 limb bud formation
GO:0060348 bone development
GO:0060349 bone morphogenesis
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060449 bud elongation involved in lung branching
GO:0060463 lung lobe morphogenesis
GO:0060484 lung-associated mesenchyme development
GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060512 prostate gland morphogenesis
GO:0060523 prostate epithelial cord elongation
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0060595 fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0060601 lateral sprouting from an epithelium
GO:0060615 mammary gland bud formation
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060667 branch elongation involved in salivary gland morphogenesis
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060688 regulation of morphogenesis of a branching structure
GO:0060915 mesenchymal cell differentiation involved in lung development
GO:0060916 mesenchymal cell proliferation involved in lung development
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071300 cellular response to retinoic acid
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090263 positive regulation of canonical Wnt signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasmic vesicle
Golgi apparatus
Secreted

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016248 Fibroblast growth factor receptor familyFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR041159 Fibroblast growth factor receptor, transmembrane domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00039 PaliferminDrugbankbiotech
DB01041 ThalidomideDrugbanksmall molecule
DB01109 HeparinDrugbanksmall molecule
DB01901 SucrosofateDrugbanksmall molecule
DB02058 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinoneDrugbanksmall molecule
DB02491 4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-AmineDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB10770 Foreskin fibroblast (neonatal)Drugbankbiotech
DB10772 Foreskin keratinocyte (neonatal)Drugbankbiotech
DB12010 FostamatinibDrugbanksmall molecule
DB12147 ErdafitinibDrugbanksmall molecule
DB15102 PemigatinibDrugbanksmall molecule
DB15685 SelpercatinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule

Interactions

65 interactions

InteractorPartnerSourcesPublicationsLink
FGFR2_HUMANFGF1_HUMANBioGRID, DIP, IntAct, MINT10618369 11069186 11714710 1697263 18199118 22955284 25241761 7499435 8576175 9700203 details
FGFR2_HUMANFGF2_HUMANBioGRID, IntAct, UniProt10830168 11390973 1697263 17981115 18199118 26267536 28514442 9700203 details
FGFR2_HUMANFGF10_HUMANBioGRID, IntAct12591959 18199118 25241761 9582367 details
FGFR2_HUMANPPM1A_HUMANBioGRID, IntAct21988832 details
FGFR2_HUMANKALM_HUMANBioGRID, IntAct19696444 details
FGFR2_HUMANGRB2_HUMANDIP, IntAct22726438 24440983 details
FGFR2_HUMANFGFR2_HUMANBioGRID, DIP, IntAct10830168 11069186 12887919 19060208 22726438 9700203 details
FGFR2_HUMANFGF7_HUMANBioGRID, IntAct11714710 1309608 7499435 9582367 details
FGFR2_HUMANCCN2_HUMANMINT23142580 details
FGFR2_HUMANPLCG1_HUMANBioGRID, DIP, IntAct15629145 24440983 25241761 details
FGFR2_HUMANFGF8_HUMANBioGRID, IntAct18199118 25241761 details
FGFR2_HUMANFGF5_HUMANBioGRID, IntAct18199118 25241761 details
FGFR2_HUMANBEX1_HUMANBioGRID, MINT25640309 details
FGFR2_HUMANBEX2_HUMANBioGRID, MINT25640309 details
FGFR2_HUMANERRFI_HUMANBioGRID, MINT25640309 details
FGFR2_HUMANGLCE_HUMANBioGRID, MINT25640309 details
FGFR2_HUMANHXC6_HUMANBioGRID, MINT25640309 details
FGFR2_HUMANMTA3_HUMANBioGRID, MINT25640309 details
FGFR2_HUMANPDLI2_HUMANBioGRID, MINT25640309 details
FGFR2_HUMANRSLAB_HUMANBioGRID, MINT25640309 details
FGFR2_HUMANS10AE_HUMANBioGRID, MINT25640309 details
FGFR2_HUMANRHBT2_HUMANBioGRID, MINT25640309 details
FGFR2_HUMANTFF1_HUMANBioGRID, MINT25640309 details
FGFR2_HUMANLRRK1_HUMANBioGRID, IntAct24947832 29513927 details
FGFR2_HUMANFGFR3_HUMANBioGRID, DIP, IntAct23972473 28514442 details
FGFR2_HUMANDUS14_HUMANBioGRID, MINT28065597 details
FGFR2_HUMANCTDSL_HUMANBioGRID, MINT28065597 details
FGFR2_HUMANCTDS1_HUMANBioGRID, MINT28065597 details
FGFR2_HUMANMTMR3_HUMANBioGRID, MINT28065597 details
FGFR2_HUMANPTPRR_HUMANBioGRID, MINT28065597 details
FGFR2_HUMANPTN6_HUMANBioGRID, MINT12887919 28065597 details
FGFR2_HUMANPTN11_HUMANBioGRID, MINT28065597 details
FGFR2_HUMANPTN12_HUMANBioGRID, MINT28065597 details
FGFR2_HUMANFGF4_HUMANIntAct9700203 details
FGFR2_HUMANNEDD4_HUMANBioGRID19953087 details
FGFR2_HUMANA4_HUMANBioGRID21832049 details
FGFR2_HUMANFGF3_HUMANBioGRID18199118 details
FGFR2_HUMANFGF6_HUMANBioGRID18199118 details
FGFR2_HUMANFGF9_HUMANBioGRID18199118 details
FGFR2_HUMANFGF17_HUMANBioGRID18199118 details
FGFR2_HUMANNECT1_HUMANBioGRID22955284 details
FGFR2_HUMANFBX7_HUMANBioGRID27503909 details
FGFR2_HUMANSHC1_HUMANBioGRID18840094 details
FGFR2_HUMANERBB2_HUMANBioGRID30898150 details
FGFR2_HUMAN1433Z_HUMANMINT18332103 details
FGFR2_HUMANLAP4B_HUMANIntAct25594178 details
FGFR2_HUMANMMP14_HUMANDIP20798051 details
FGFR2_HUMANP85A_HUMANBioGRID18374639 details
FGFR2_HUMANITA5_HUMANBioGRID15728256 details
FGFR2_HUMANSTAT3_HUMANBioGRID20388777 details
FGFR2_HUMANPRGR_HUMANBioGRID21464042 details
FGFR2_HUMANSTA5A_HUMANBioGRID21464042 details
FGFR2_HUMANSTA5B_HUMANBioGRID21464042 details
FGFR2_HUMANFRS2_HUMANBioGRID15629145 21596750 details
FGFR2_HUMANCBL_HUMANBioGRID15190072 details
FGFR2_HUMANLYN_HUMANBioGRID15190072 details
FGFR2_HUMANFYN_HUMANBioGRID15190072 details
FGFR2_HUMANHGS_HUMANBioGRID19362549 details
FGFR2_HUMANEPHA4_HUMANBioGRID16365308 details
FGFR2_HUMANSRC_HUMANBioGRID18840094 details
FGFR2_HUMANKLOTB_HUMANBioGRID17623664 details
FGFR2_HUMANIWS1_HUMANBioGRID24462114 details
FGFR2_HUMANSETD2_HUMANBioGRID24462114 details
FGFR2_HUMANMO4L1_HUMANBioGRID24462114 details
FGFR2_HUMANPTBP1_HUMANBioGRID24462114 details