Entity Details

Primary name PSB4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28070
EntryNamePSB4_HUMAN
FullNameProteasome subunit beta type-4
TaxID9606
Evidenceevidence at protein level
Length264
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesPSMB4

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0001530 lipopolysaccharide binding
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0006521 regulation of cellular amino acid metabolic process
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016032 viral process
GO:0016579 protein deubiquitination
GO:0019774 proteasome core complex, beta-subunit complex
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0036064 ciliary basal body
GO:0036388 pre-replicative complex assembly
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0050852 T cell receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070062 extracellular exosome
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001353 Proteasome, subunit alpha/betaFamilyFamily
IPR016050 Proteasome beta-type subunit, conserved siteSiteConserved site
IPR016295 Proteasome subunit beta 4FamilyFamily
IPR023333 Proteasome B-type subunitFamilyFamily
IPR029055 Nucleophile aminohydrolases, N-terminalFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617591 OMIMProteasome-associated autoinflammatory syndrome 3 (PRAAS3)An autoinflammatory disorder characterized by onset in early infancy and recurrent fever, nodular dermatitis, myositis, panniculitis-induced lipodystrophy, lymphadenopathy, and immune dysregulation. Variable accompanying features may include joint contractures, hepatosplenomegaly, anemia, thrombocytopenia, recurrent infections, autoantibodies, and hypergammaglobulinemia. Some patients may have intracranial calcifications. PRAAS3 inheritance is autosomal recessive or digenic. The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry.

Drugs

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DrugNameSourceType
DB08515 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDEDrugbanksmall molecule

Interactions

71 interactions

InteractorPartnerSourcesPublicationsLink
PSB4_HUMANSMAD1_HUMANBioGRID, HPRD, IntAct, MINT11438941 11571290 12097147 15231748 32296183 details
PSB4_HUMANPSB7_HUMANBioGRID, IntAct, MINT17948026 22863883 22939629 26186194 26344197 28514442 details
PSB4_HUMANPOMP_HUMANBioGRID, IntAct, MINT17189198 17948026 26186194 28514442 details
PSB4_HUMANPSB5_HUMANBioGRID, IntAct, MINT17948026 22863883 22939629 26186194 26344197 28514442 details
PSB4_HUMANKPCA_HUMANBioGRID, IntAct21988832 details
PSB4_HUMANCUL1_HUMANBioGRID, IntAct21145461 9636170 details
PSB4_HUMANFSD2_HUMANBioGRID, IntAct25416956 details
PSB4_HUMANPSA3_HUMANBioGRID, IntAct22863883 22939629 25416956 26186194 26344197 28514442 details
PSB4_HUMANPSB1_HUMANBioGRID, IntAct22863883 22939629 26186194 26344197 28514442 32296183 details
PSB4_HUMANGRAN_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANKR195_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANTLE5_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANCCD57_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANMYOZ3_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANCNOT2_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANKANK2_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANCA109_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANPROP1_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANP4HA3_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANDTX2_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANHGS_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANTEKT5_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANSYP2L_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANSPG21_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANPITX2_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANSOLH1_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANGBRL1_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANBCL6_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANHEMK1_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANAP2D_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANPKN1_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANPFD5_HUMANBioGRID, IntAct32296183 details
PSB4_HUMANPSB3_HUMANBioGRID, IntAct17948026 22863883 22939629 26186194 26344197 28514442 details
PSB4_HUMANPRKN_HUMANBioGRID, IntAct23503661 32814053 details
PSB4_HUMANRNF11_HUMANIntAct32814053 details
PSB4_HUMANATX1_HUMANIntAct32814053 details
PSB4_HUMANTADBP_HUMANIntAct32814053 details
PSB4_HUMANOAZ1_HUMANBioGRID11571290 details
PSB4_HUMANPRP19_HUMANBioGRID15660529 details
PSB4_HUMANPSB8_HUMANBioGRID17948026 22863883 22939629 26344197 details
PSB4_HUMANPSB10_HUMANBioGRID17948026 22939629 26344197 details
PSB4_HUMANCRBN_HUMANBioGRID23026050 details
PSB4_HUMANA4_HUMANBioGRID21832049 details
PSB4_HUMANPSMD2_HUMANBioGRID22939629 26344197 28539385 details
PSB4_HUMANPSMG3_HUMANBioGRID17189198 details
PSB4_HUMANPSA2_HUMANBioGRID, IntAct12376572 15660529 15887188 19193609 22863883 22939629 26186194 26344197 28514442 details
PSB4_HUMANTRAF6_HUMANIntAct17353931 details
PSB4_HUMANHLAC_HUMANIntAct17353931 details
PSB4_HUMANHLAB_HUMANIntAct17353931 details
PSB4_HUMANIKKE_HUMANIntAct17353931 details
PSB4_HUMANNDKB_HUMANIntAct17353931 details
PSB4_HUMANMTMRA_HUMANIntAct25416956 details
PSB4_HUMANFBX7_HUMANBioGRID, IntAct26186194 27497298 28514442 details
PSB4_HUMANPSA5_HUMANBioGRID, IntAct22863883 22939629 24720748 26186194 26344197 28514442 details
PSB4_HUMANPSA4_HUMANBioGRID, IntAct22863883 22939629 26186194 26344197 28514442 9311996 details
PSB4_HUMANDISC1_HUMANIntAct31413325 details
PSB4_HUMANRD23A_HUMANBioGRID19013454 details
PSB4_HUMANSEM1_HUMANBioGRID18775730 details
PSB4_HUMANSEML_HUMANBioGRID18775730 details
PSB4_HUMANNUB1_HUMANBioGRID16707496 details
PSB4_HUMANUBD_HUMANBioGRID16707496 details
PSB4_HUMANPRS8_HUMANBioGRID16707496 22939629 24720748 26344197 details
PSB4_HUMANUBP7_HUMANBioGRID19193609 details
PSB4_HUMANAKT1_HUMANBioGRID16027165 details
PSB4_HUMANPSDE_HUMANBioGRID17323924 22939629 26344197 27428775 28821611 details
PSB4_HUMANPSMD9_HUMANBioGRID24720748 details
PSB4_HUMANROA1_HUMANBioGRID24720748 details
PSB4_HUMANTRI18_HUMANBioGRID26748699 details
PSB4_HUMANUBE3A_HUMANBioGRID22645313 29426014 30257870 details
PSB4_HUMANSMG7_HUMANBioGRID29395067 details
PSB4_HUMANPLK1_HUMANHPRD11205743 details