Entity Details

Primary name EPHA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29317
EntryNameEPHA2_HUMAN
FullNameEphrin type-A receptor 2
TaxID9606
Evidenceevidence at protein level
Length976
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesEPHA2

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001570 vasculogenesis
GO:0001618 virus receptor activity
GO:0001649 osteoblast differentiation
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009986 cell surface
GO:0010591 regulation of lamellipodium assembly
GO:0014028 notochord formation
GO:0016477 cell migration
GO:0016525 negative regulation of angiogenesis
GO:0019838 growth factor binding
GO:0021915 neural tube development
GO:0030027 lamellipodium
GO:0030216 keratinocyte differentiation
GO:0030316 osteoclast differentiation
GO:0031256 leading edge membrane
GO:0031258 lamellipodium membrane
GO:0032587 ruffle membrane
GO:0032682 negative regulation of chemokine production
GO:0033598 mammary gland epithelial cell proliferation
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0033674 positive regulation of kinase activity
GO:0036342 post-anal tail morphogenesis
GO:0043005 neuron projection
GO:0043235 receptor complex
GO:0043491 protein kinase B signaling
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0045296 cadherin binding
GO:0045765 regulation of angiogenesis
GO:0046058 cAMP metabolic process
GO:0046849 bone remodeling
GO:0048013 ephrin receptor signaling pathway
GO:0048320 axial mesoderm formation
GO:0048870 cell motility
GO:0050830 defense response to Gram-positive bacterium
GO:0051898 negative regulation of protein kinase B signaling
GO:0060035 notochord cell development
GO:0060326 cell chemotaxis
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0070160 tight junction
GO:0070309 lens fiber cell morphogenesis
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070848 response to growth factor
GO:0072659 protein localization to plasma membrane
GO:0090630 activation of GTPase activity
GO:1901491 negative regulation of lymphangiogenesis
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903348 positive regulation of bicellular tight junction assembly
GO:1904238 pericyte cell differentiation

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001090 Ephrin receptor ligand binding domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001426 Tyrosine-protein kinase, receptor class V, conserved siteSiteConserved site
IPR001660 Sterile alpha motif domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016257 Ephrin receptor type-A /type-BFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027936 Ephrin receptor, transmembrane domainDomainDomain
IPR034263 Ephrin type-A receptor 2, ligand binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
116600 OMIMCataract 6, multiple types (CTRCT6)An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT6 includes posterior polar and age-related cortical cataracts, among others. Posterior polar cataract is a subcapsular opacity, usually disk-shaped, located at the back of the lens. Age-related cortical cataract is a developmental punctate opacity restricted to the cortex. The cataract is white or cerulean, increases in number with age, but rarely affects vision. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

110 interactions

InteractorPartnerSourcesPublicationsLink
EPHA2_HUMANEPHA2_HUMANBioGRID, HPRD, MINT17192257 18797457 19525919 28065597 28205554 7890684 7982920 details
EPHA2_HUMANEFNA1_HUMANDIP, HPRD, IntAct, MINT14692877 19525919 19573808 20505120 22244754 7973638 8755474 details
EPHA2_HUMANPTN11_HUMANBioGRID, HPRD, MINT, UniProt10655584 28065597 details
EPHA2_HUMANARBK1_HUMANBioGRID, IntAct21988832 details
EPHA2_HUMANCDK17_HUMANBioGRID, IntAct21988832 details
EPHA2_HUMANIMA4_HUMANBioGRID, IntAct21988832 details
EPHA2_HUMANPSME2_HUMANBioGRID, IntAct21988832 details
EPHA2_HUMANNUDT9_HUMANBioGRID, IntAct21988832 details
EPHA2_HUMANGATD1_HUMANBioGRID, IntAct21988832 details
EPHA2_HUMANRBL1_HUMANBioGRID, IntAct21988832 details
EPHA2_HUMANLSM7_HUMANBioGRID, IntAct21988832 details
EPHA2_HUMANEPHA7_HUMANIntAct22036564 details
EPHA2_HUMANEFNA5_HUMANDIP, HPRD20228801 20505120 9245480 details
EPHA2_HUMANSHIP2_HUMANDIP22244754 details
EPHA2_HUMANDUS18_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANPTN7_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANPTPRR_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANILKAP_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANPPM1L_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANPPM1A_HUMANMINT28065597 details
EPHA2_HUMANDUS14_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANDUS19_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANDUS26_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANDUS29_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANSTYX_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANTPTE_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANTPTE2_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANSLAP1_HUMANBioGRID, HPRD24457997 7543898 details
EPHA2_HUMANSHC1_HUMANBioGRID, HPRD12400011 details
EPHA2_HUMANGRB2_HUMANBioGRID, HPRD12400011 details
EPHA2_HUMANP85A_HUMANBioGRID7982920 details
EPHA2_HUMANPPAC_HUMANBioGRID, HPRD12167657 details
EPHA2_HUMANA4_HUMANBioGRID21832049 details
EPHA2_HUMANUBE4A_HUMANBioGRID24457997 details
EPHA2_HUMANERBB2_HUMANBioGRID28205554 30898150 details
EPHA2_HUMANABCB5_HUMANBioGRID28205554 details
EPHA2_HUMANARAF_HUMANBioGRID28205554 details
EPHA2_HUMANARNT_HUMANBioGRID28205554 details
EPHA2_HUMANAURKA_HUMANBioGRID28205554 details
EPHA2_HUMANBECN1_HUMANBioGRID28205554 details
EPHA2_HUMANCBLC_HUMANBioGRID28205554 details
EPHA2_HUMANCCND2_HUMANBioGRID28205554 details
EPHA2_HUMANCDK4_HUMANBioGRID28205554 details
EPHA2_HUMANCDK6_HUMANBioGRID28205554 details
EPHA2_HUMANCDN2A_HUMANBioGRID28205554 details
EPHA2_HUMANARF_HUMANBioGRID28205554 details
EPHA2_HUMANAKT1_HUMANBioGRID28205554 details
EPHA2_HUMANCDN2B_HUMANBioGRID28205554 details
EPHA2_HUMANMP2K3_HUMANBioGRID28205554 28628118 details
EPHA2_HUMANFGFR4_HUMANBioGRID28205554 details
EPHA2_HUMANFZR1_HUMANBioGRID28205554 details
EPHA2_HUMANGLIS2_HUMANBioGRID28205554 details
EPHA2_HUMANGRM1_HUMANBioGRID28205554 details
EPHA2_HUMANHGF_HUMANBioGRID28205554 details
EPHA2_HUMANERD22_HUMANBioGRID28205554 details
EPHA2_HUMANLATS2_HUMANBioGRID28205554 details
EPHA2_HUMANMP2K5_HUMANBioGRID28205554 details
EPHA2_HUMANMET_HUMANBioGRID28205554 details
EPHA2_HUMANMERL_HUMANBioGRID28205554 details
EPHA2_HUMANPGFRA_HUMANBioGRID28205554 details
EPHA2_HUMANTF65_HUMANBioGRID28205554 details
EPHA2_HUMANTEAD2_HUMANBioGRID28205554 details
EPHA2_HUMANP53_HUMANBioGRID28205554 details
EPHA2_HUMANCD44_HUMANBioGRID28205554 details
EPHA2_HUMANCDC42_HUMANBioGRID28205554 details
EPHA2_HUMANCDN2C_HUMANBioGRID28205554 details
EPHA2_HUMANHIF1A_HUMANBioGRID28205554 details
EPHA2_HUMANMP2K6_HUMANBioGRID28205554 details
EPHA2_HUMANMK14_HUMANBioGRID28205554 details
EPHA2_HUMANMDM4_HUMANBioGRID28205554 details
EPHA2_HUMANMSH2_HUMANBioGRID28205554 details
EPHA2_HUMANMYC_HUMANBioGRID28205554 details
EPHA2_HUMANNF1_HUMANBioGRID28205554 details
EPHA2_HUMANNFIC_HUMANBioGRID28205554 details
EPHA2_HUMANPTEN_HUMANBioGRID28205554 details
EPHA2_HUMANRAF1_HUMANBioGRID28205554 details
EPHA2_HUMANRASF1_HUMANBioGRID28205554 details
EPHA2_HUMANSTK11_HUMANBioGRID28205554 details
EPHA2_HUMANANXA1_HUMANBioGRID32737118 details
EPHA2_HUMANP85B_HUMANHPRD7982920 details
EPHA2_HUMANFAK1_HUMANBioGRID, UniProt10655584 details
EPHA2_HUMANHS90B_HUMANIntAct22939624 details
EPHA2_HUMANCTNB1_HUMANBioGRID, DIP18948590 34079125 details
EPHA2_HUMANCBL_HUMANBioGRID, HPRD12147253 12496371 22509030 23874206 32737118 details
EPHA2_HUMANHS90A_HUMANBioGRID22939624 details
EPHA2_HUMANITA3_HUMANBioGRID23874206 details
EPHA2_HUMANITB1_HUMANBioGRID23874206 details
EPHA2_HUMANITB3_HUMANBioGRID23874206 details
EPHA2_HUMANITB5_HUMANBioGRID23874206 details
EPHA2_HUMANITAV_HUMANBioGRID23874206 details
EPHA2_HUMANCLH1_HUMANBioGRID23874206 details
EPHA2_HUMANAP2M1_HUMANBioGRID23874206 details
EPHA2_HUMANAP2B1_HUMANBioGRID23874206 details
EPHA2_HUMANAP2A1_HUMANBioGRID23874206 details
EPHA2_HUMANAP2S1_HUMANBioGRID23874206 details
EPHA2_HUMANEPS15_HUMANBioGRID23874206 details
EPHA2_HUMANTS101_HUMANBioGRID27764233 details
EPHA2_HUMANOPCM_HUMANBioGRID22585860 details
EPHA2_HUMANSOCS2_HUMANBioGRID28883622 details
EPHA2_HUMANSOCS6_HUMANBioGRID28883622 details
EPHA2_HUMANCUL5_HUMANBioGRID28883622 details
EPHA2_HUMANARRD3_HUMANBioGRID29416926 details
EPHA2_HUMANBACD2_HUMANHPRD7536959 details
EPHA2_HUMANTIAM1_HUMANHPRD14988728 details
EPHA2_HUMANEFNA4_HUMANHPRD10607706 8755474 details
EPHA2_HUMANEFNA3_HUMANHPRD12907451 details
EPHA2_HUMANEFNA2_HUMANHPRD8755474 details
EPHA2_HUMANRASA1_HUMANHPRD16051609 details
EPHA2_HUMANCADH5_HUMANHPRD16481735 details
EPHA2_HUMANCLD4_HUMANHPRD16236711 details