Entity Details

Primary name EPHB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29323
EntryNameEPHB2_HUMAN
FullNameEphrin type-B receptor 2
TaxID9606
Evidenceevidence at protein level
Length1055
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesEPHB2

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001540 amyloid-beta binding
GO:0001655 urogenital system development
GO:0001933 negative regulation of protein phosphorylation
GO:0002639 positive regulation of immunoglobulin production
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007162 negative regulation of cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007413 axonal fasciculation
GO:0007611 learning or memory
GO:0007612 learning
GO:0008046 axon guidance receptor activity
GO:0010628 positive regulation of gene expression
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021631 optic nerve morphogenesis
GO:0021952 central nervous system projection neuron axonogenesis
GO:0022038 corpus callosum development
GO:0030193 regulation of blood coagulation
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0030890 positive regulation of B cell proliferation
GO:0031290 retinal ganglion cell axon guidance
GO:0031915 positive regulation of synaptic plasticity
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033674 positive regulation of kinase activity
GO:0042113 B cell activation
GO:0042472 inner ear morphogenesis
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0044877 protein-containing complex binding
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048013 ephrin receptor signaling pathway
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048170 positive regulation of long-term neuronal synaptic plasticity
GO:0048593 camera-type eye morphogenesis
GO:0050771 negative regulation of axonogenesis
GO:0050878 regulation of body fluid levels
GO:0051389 obsolete inactivation of MAPKK activity
GO:0051965 positive regulation of synapse assembly
GO:0060021 roof of mouth development
GO:0060996 dendritic spine development
GO:0060997 dendritic spine morphogenesis
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071679 commissural neuron axon guidance
GO:0097104 postsynaptic membrane assembly
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:0099557 trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
GO:0106028 neuron projection retraction
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1904782 negative regulation of NMDA glutamate receptor activity
GO:1904783 positive regulation of NMDA glutamate receptor activity

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001090 Ephrin receptor ligand binding domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001426 Tyrosine-protein kinase, receptor class V, conserved siteSiteConserved site
IPR001660 Sterile alpha motif domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-likeDomainDomain
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016257 Ephrin receptor type-A /type-BFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027936 Ephrin receptor, transmembrane domainDomainDomain
IPR034238 Ephrin type-B receptor 2, ligand binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618462 OMIMBleeding disorder, platelet-type 22 (BDPLT22)An autosomal recessive disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after minor injuries, and menorrhagia. The disease may be caused by variants affecting the gene represented in this entry.
176807 OMIMProstate cancer (PC)A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. The gene represented in this entry may be involved in disease pathogenesis. EPHB2 mutations have been found in a prostate cancer cell line derived from a brain metastasis.

Drugs

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DrugNameSourceType
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
EPHB2_HUMANAFAD_HUMANBioGRID, MINT9707552 details
EPHB2_HUMANNU153_HUMANMINT17255949 details
EPHB2_HUMANEFNB2_HUMANBioGRID, HPRD, IntAct11780069 26186194 28514442 details
EPHB2_HUMANMTMRE_HUMANBioGRID, MINT28065597 details
EPHB2_HUMANTRI54_HUMANBioGRID, IntAct31391242 details
EPHB2_HUMANCOMT_HUMANIntAct32814053 details
EPHB2_HUMANPAHX_HUMANIntAct32814053 details
EPHB2_HUMANCLN6_HUMANIntAct32814053 details
EPHB2_HUMANJPH3_HUMANIntAct32814053 details
EPHB2_HUMANSPRE1_HUMANIntAct32814053 details
EPHB2_HUMANTADBP_HUMANIntAct32814053 details
EPHB2_HUMANSRC_HUMANBioGRID, HPRD10644995 18713744 9632142 details
EPHB2_HUMANRASA1_HUMANBioGRID, HPRD10644995 9233798 details
EPHB2_HUMANCRK_HUMANBioGRID10644995 details
EPHB2_HUMANEPHB2_HUMANBioGRID, HPRD10572014 17192257 18797457 9233798 9632142 9933164 details
EPHB2_HUMANYES_HUMANBioGRID9632142 details
EPHB2_HUMANPLCG1_HUMANBioGRID9632142 details
EPHB2_HUMANABL1_HUMANBioGRID, HPRD11494128 details
EPHB2_HUMANABL2_HUMANBioGRID, HPRD11494128 details
EPHB2_HUMANFBX7_HUMANBioGRID27503909 details
EPHB2_HUMANERBB2_HUMANBioGRID30898150 details
EPHB2_HUMANSDCB1_HUMANHPRD9883737 details
EPHB2_HUMANPICK1_HUMANHPRD10839360 9883737 details
EPHB2_HUMANRBL1_HUMANIntAct17353931 details
EPHB2_HUMANTP4A2_HUMANIntAct17353931 details
EPHB2_HUMANMK14_HUMANMINT17255949 details
EPHB2_HUMANPPAC_HUMANBioGRID, HPRD9499402 details
EPHB2_HUMANRYK_HUMANBioGRID, HPRD11956217 details
EPHB2_HUMANITSN1_HUMANBioGRID, HPRD12389031 details
EPHB2_HUMANALK_HUMANBioGRID14968112 details
EPHB2_HUMANHMMR_HUMANBioGRID22610405 details
EPHB2_HUMANSPSB4_HUMANBioGRID28931592 details
EPHB2_HUMANSPSB1_HUMANBioGRID28931592 details
EPHB2_HUMANNMDZ1_HUMANBioGRID, HPRD11754835 22544902 details
EPHB2_HUMANRRAS_HUMANHPRD10570155 details
EPHB2_HUMANEFNB1_HUMANHPRD8878483 details
EPHB2_HUMANNCK1_HUMANHPRD9233798 details
EPHB2_HUMANERF_HUMANHPRD10330152 details
EPHB2_HUMANEFNA5_HUMANHPRD15107857 details
EPHB2_HUMANSYNJ1_HUMANHPRD15821731 details
EPHB2_HUMANSH2D3_HUMANHPRD10542222 details
EPHB2_HUMANNMDE2_HUMANHPRD11799243 details
EPHB2_HUMANSDC2_HUMANHPRD11580899 details
EPHB2_HUMANVAV2_HUMANHPRD15848800 details
EPHB2_HUMANKALRN_HUMANHPRD12546821 details
EPHB2_HUMANARHG6_HUMANHPRD10523848 details
EPHB2_HUMANGRB2_HUMANHPRD16298995 details
EPHB2_HUMANVEGFA_HUMANHPRD17318185 details
EPHB2_HUMANKSR1_HUMANHPRD11940661 details
EPHB2_HUMANMMP2_HUMANHPRD18713744 details
EPHB2_HUMANMMP9_HUMANHPRD18713744 details
EPHB2_HUMANFOS_HUMANHPRD12972619 7816602 details