Entity Details

Primary name 1433B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP31946
EntryName1433B_HUMAN
FullName14-3-3 protein beta/alpha
TaxID9606
Evidenceevidence at protein level
Length246
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesYWHAB

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0002250 adaptive immune response
GO:0004860 protein kinase inhibitor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005774 vacuolar membrane
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0006605 protein targeting
GO:0008022 protein C-terminus binding
GO:0016020 membrane
GO:0016032 viral process
GO:0017053 transcription repressor complex
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0035308 negative regulation of protein dephosphorylation
GO:0035329 hippo signaling
GO:0042470 melanosome
GO:0042802 identical protein binding
GO:0042826 histone deacetylase binding
GO:0043085 positive regulation of catalytic activity
GO:0043488 regulation of mRNA stability
GO:0044877 protein-containing complex binding
GO:0045296 cadherin binding
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048471 perinuclear region of cytoplasm
GO:0050815 phosphoserine residue binding
GO:0051219 phosphoprotein binding
GO:0051220 cytoplasmic sequestering of protein
GO:0070062 extracellular exosome
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Melanosome
Vacuole membrane

Domains

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DomainNameCategoryType
IPR000308 14-3-3 proteinFamilyFamily
IPR023409 14-3-3 protein, conserved siteSiteConserved site
IPR023410 14-3-3 domainDomainDomain
IPR036815 14-3-3 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB09130 CopperDrugbanksmall molecule
DB12695 Phenethyl IsothiocyanateDrugbanksmall molecule

Interactions

198 interactions

InteractorPartnerSourcesPublicationsLink
1433B_HUMANIGF1R_HUMANBioGRID, HPRD, IntAct, MINT14651979 15629149 17353931 9581554 details
1433B_HUMANSL9A1_HUMANHPRD, MINT11279064 16717153 details
1433B_HUMANTESK1_HUMANBioGRID, HPRD, MINT11555644 details
1433B_HUMANITB1_HUMANBioGRID, MINT11313964 details
1433B_HUMANTSC2_HUMANBioGRID, HPRD, IntAct, MINT12176984 12364343 12438239 12468542 12582162 15324660 16636147 17353931 20169078 24255178 28514442 details
1433B_HUMANWEE1_HUMANBioGRID, HPRD, IntAct, MINT10775038 15324660 17353931 details
1433B_HUMANKCNK3_HUMANBioGRID, HPRD, MINT12433946 12437930 23772394 details
1433B_HUMANMPIP2_HUMANBioGRID, IntAct, MINT10713667 12871587 15173315 16672277 26496610 27432908 28514442 7644510 details
1433B_HUMANKS6A1_HUMANBioGRID, HPRD, MINT12618428 details
1433B_HUMANTPD53_HUMANBioGRID, HPRD, IntAct, MINT12963375 24255178 details
1433B_HUMANBRAF_HUMANBioGRID, HPRD, IntAct, MINT10931830 12620389 15324660 17353931 24255178 27034005 27684187 28514442 31980649 details
1433B_HUMANE41L3_HUMANBioGRID, HPRD, IntAct, MINT11996670 15324660 16368544 17353931 24255178 24366813 details
1433B_HUMANRAF1_HUMANBioGRID, HPRD, IntAct, MINT10620507 10848612 11697890 12360521 12620389 16041367 16093354 19595761 24255178 25852190 28514442 31980649 7644510 7882972 7935795 8085158 8702721 details
1433B_HUMANDYR1A_HUMANBioGRID, HPRD, IntAct17229891 17353931 30773093 details
1433B_HUMANPTN3_HUMANBioGRID, HPRD, IntAct, MINT17353931 27432908 27880917 28330616 28514442 28675297 9341175 details
1433B_HUMANCDK14_HUMANHPRD, IntAct16775625 details
1433B_HUMANM3K5_HUMANIntAct15023544 21771788 details
1433B_HUMANMPIP1_HUMANBioGRID, HPRD, IntAct27432908 28330616 28675297 7644510 details
1433B_HUMANMK07_HUMANBioGRID, HPRD, MINT14679215 details
1433B_HUMANINSR_HUMANHPRD, IntAct15629149 details
1433B_HUMANSRPK2_HUMANBioGRID, IntAct, MINT19592491 23602568 details
1433B_HUMANCBL_HUMANBioGRID, HPRD, IntAct, MINT11157475 11697890 19380743 24255178 28514442 9367879 details
1433B_HUMANING1_HUMANBioGRID, HPRD, MINT16581770 details
1433B_HUMANSKP2_HUMANBioGRID, MINT19270694 details
1433B_HUMANADA22_HUMANHPRD, IntAct16868027 18762889 details
1433B_HUMAN1433E_HUMANBioGRID, DIP, HPRD, IntAct12507503 17085597 17979178 20936779 24255178 26344197 28514442 30135474 31536960 31980649 details
1433B_HUMANOTU7B_HUMANIntAct18029035 details
1433B_HUMANBAD_HUMANBioGRID, HPRD, IntAct, MINT11697890 21900206 24255178 28514442 31980649 9369453 details
1433B_HUMANCDN1B_HUMANBioGRID, HPRD, IntAct15057270 details
1433B_HUMANGAB2_HUMANIntAct, MINT19172738 28514442 details
1433B_HUMANB2L11_HUMANBioGRID, HPRD, IntAct16282323 details
1433B_HUMANKPCZ_HUMANBioGRID, HPRD, MINT10620507 21900206 details
1433B_HUMANKANK1_HUMANBioGRID, UniProt18458160 details
1433B_HUMAN1433B_HUMANDIP, HPRD, IntAct12424248 12453887 17085597 23622247 28514442 details
1433B_HUMANMPIP3_HUMANBioGRID, DIP, HPRD, IntAct10681541 12937170 15284440 15791647 16205633 19470455 24255178 27880917 28330616 28514442 28675297 details
1433B_HUMAN1433G_HUMANBioGRID, DIP, HPRD, IntAct15324660 17085597 24255178 24981860 26344197 28514442 details
1433B_HUMAN1433T_HUMANBioGRID, DIP, IntAct17085597 20618440 22863883 24255178 28514442 details
1433B_HUMANMTR1A_HUMANBioGRID, IntAct26514267 details
1433B_HUMANHES1_HUMANBioGRID, MINT21900206 details
1433B_HUMANIRS1_HUMANBioGRID, HPRD, IntAct28514442 30240640 9422753 details
1433B_HUMANDACT1_HUMANBioGRID, UniProt21262972 details
1433B_HUMANLRRK2_HUMANBioGRID, IntAct20642453 24510904 24947832 31046837 details
1433B_HUMANE41L1_HUMANHPRD, IntAct16368544 28514442 details
1433B_HUMANRND3_HUMANIntAct23622247 details
1433B_HUMANCAF1A_HUMANBioGRID, IntAct21209461 28514442 details
1433B_HUMANATX1_HUMANBioGRID, IntAct, UniProt25959826 32814053 details
1433B_HUMANRGRF1_HUMANBioGRID9543386 details
1433B_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
1433B_HUMANTNAP3_HUMANBioGRID, HPRD18029035 19615732 8702721 details
1433B_HUMANEXO1_HUMANBioGRID, IntAct21533173 22222486 24255178 details
1433B_HUMANUCP3_HUMANBioGRID, HPRD10785390 details
1433B_HUMANERRFI_HUMANBioGRID20351267 details
1433B_HUMANKCNKF_HUMANHPRD12433946 details
1433B_HUMANMINK1_HUMANHPRD15032605 details
1433B_HUMANHD_HUMANIntAct17500595 32814053 details
1433B_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 31980649 details
1433B_HUMANTESK2_HUMANBioGRID, HPRD, IntAct11555644 28514442 details
1433B_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
1433B_HUMANTTP_HUMANBioGRID, HPRD11886850 14688255 17170118 details
1433B_HUMANMLXIP_HUMANBioGRID, HPRD12446771 details
1433B_HUMANLYST_HUMANBioGRID, HPRD11984006 details
1433B_HUMANKCC2B_HUMANBioGRID12619878 details
1433B_HUMANSAMN1_HUMANBioGRID20478393 details
1433B_HUMANMYO1C_HUMANIntAct24636949 details
1433B_HUMANCOP1_HUMANBioGRID21135113 details
1433B_HUMANH31_HUMANBioGRID16246723 25330109 details
1433B_HUMANA4_HUMANBioGRID, IntAct21832049 32814053 details
1433B_HUMANRON_HUMANBioGRID, HPRD12919677 14505491 details
1433B_HUMANCD11B_HUMANBioGRID, HPRD15883043 details
1433B_HUMANPRP6_HUMANBioGRID10848612 details
1433B_HUMANITB4_HUMANHPRD12919677 details
1433B_HUMANUCP2_HUMANBioGRID, HPRD10785390 details
1433B_HUMANKCC2A_HUMANBioGRID12619878 details
1433B_HUMANTISB_HUMANBioGRID17030608 details
1433B_HUMANEPB41_HUMANHPRD16368544 details
1433B_HUMANBAX_HUMANBioGRID22785534 details
1433B_HUMANPDE3B_HUMANHPRD12453887 details
1433B_HUMANRGS3_HUMANBioGRID, HPRD, MINT10862767 11985497 details
1433B_HUMANBID_HUMANHPRD, MINT12871587 details
1433B_HUMANHS71A_HUMANBioGRID, HPRD, MINT15324660 details
1433B_HUMANHS71B_HUMANBioGRID, HPRD, MINT15324660 details
1433B_HUMANM3K3_HUMANHPRD, IntAct, MINT14743216 18308725 28514442 details
1433B_HUMANRADIL_HUMANHPRD, IntAct, MINT15324660 17353931 details
1433B_HUMANU520_HUMANHPRD, IntAct, MINT15324660 17353931 details
1433B_HUMANAKP13_HUMANBioGRID, HPRD, IntAct, MINT15229649 15324660 15691829 17353931 28514442 details
1433B_HUMANRMD3_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 18771726 21972092 25862004 28514442 32877691 details
1433B_HUMANPARD3_HUMANBioGRID, HPRD, IntAct, MINT14676191 15324660 17353931 24255178 28514442 details
1433B_HUMANAP5Z1_HUMANMINT15324660 details
1433B_HUMANRGPS2_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 24255178 28514442 details
1433B_HUMANSRPK1_HUMANIntAct, MINT15324660 17353931 details
1433B_HUMANLSR_HUMANBioGRID, IntAct, MINT15324660 17353931 28514442 details
1433B_HUMANPI3R4_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 details
1433B_HUMANMYCPP_HUMANBioGRID, IntAct, MINT15324660 17353931 24255178 28514442 details
1433B_HUMANTSC1_HUMANBioGRID, HPRD, IntAct, MINT12176984 15324660 28514442 details
1433B_HUMANMARK3_HUMANBioGRID, IntAct, MINT15324660 16959763 17353931 20642453 24255178 28514442 29089450 details
1433B_HUMANALS2_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 28514442 details
1433B_HUMANMYCB2_HUMANBioGRID, IntAct, MINT15324660 17353931 28514442 details
1433B_HUMANANM5_HUMANMINT15324660 details
1433B_HUMANTBA1A_HUMANMINT15324660 details
1433B_HUMANMILK1_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 28514442 details
1433B_HUMANCRTC2_HUMANBioGRID, HPRD, IntAct, MINT15324660 15454081 24255178 28514442 details
1433B_HUMANACINU_HUMANIntAct, MINT15324660 17353931 details
1433B_HUMANUBP8_HUMANBioGRID, IntAct, MINT15324660 17353931 24255178 26214742 28514442 details
1433B_HUMANPRKDC_HUMANMINT15324660 details
1433B_HUMANM3K2_HUMANBioGRID, IntAct, MINT15324660 17353931 24255178 26496610 28514442 details
1433B_HUMANFRMD6_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 24366813 28514442 details
1433B_HUMANK0930_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 24255178 26186194 28514442 details
1433B_HUMANLBR_HUMANMINT15324660 details
1433B_HUMANGAPD1_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 24255178 26344197 28514442 details
1433B_HUMANMDM4_HUMANBioGRID, HPRD, MINT16227609 16511560 18356162 21925390 29523541 details
1433B_HUMAN3BP5L_HUMANIntAct17353931 28514442 details
1433B_HUMANLIPB1_HUMANBioGRID, IntAct17353931 24255178 28514442 details
1433B_HUMANABL1_HUMANBioGRID, HPRD, IntAct15696159 16888623 25852190 28514442 details
1433B_HUMANSRSF3_HUMANBioGRID, HPRD, IntAct15324660 17353931 details
1433B_HUMANCWC22_HUMANIntAct17353931 details
1433B_HUMANCRNL1_HUMANIntAct17353931 details
1433B_HUMANKI20B_HUMANIntAct17353931 details
1433B_HUMANM3K21_HUMANBioGRID, IntAct17353931 24255178 28514442 details
1433B_HUMANU5S1_HUMANBioGRID, IntAct17353931 28515276 details
1433B_HUMANSH3B4_HUMANIntAct17353931 28514442 details
1433B_HUMANPAK4_HUMANBioGRID, IntAct17353931 24255178 28514442 details
1433B_HUMANGBF1_HUMANBioGRID, IntAct17353931 24255178 details
1433B_HUMANRNPS1_HUMANBioGRID, HPRD, IntAct15324660 17353931 details
1433B_HUMANDFFA_HUMANIntAct17353931 details
1433B_HUMANMP2K1_HUMANBioGRID, IntAct10409742 17979178 24255178 31980649 details
1433B_HUMANE41L2_HUMANIntAct17353931 details
1433B_HUMANSMAG2_HUMANBioGRID, IntAct15324660 17353931 24255178 28514442 29395067 details
1433B_HUMANUBP43_HUMANBioGRID, IntAct19615732 28514442 30135474 details
1433B_HUMANSSH1_HUMANBioGRID, MINT15159416 19329994 27432908 28675297 details
1433B_HUMANGEM_HUMANBioGRID, HPRD, IntAct, MINT14701738 30833792 details
1433B_HUMANHECD1_HUMANIntAct17353931 details
1433B_HUMANHDAC4_HUMANBioGRID, IntAct, MINT10869435 10958686 23752268 24255178 27684187 28514442 31040226 details
1433B_HUMANLRFN1_HUMANIntAct17353931 28514442 details
1433B_HUMANISCU_HUMANIntAct17353931 details
1433B_HUMANKLC4_HUMANBioGRID, IntAct17353931 24255178 28514442 details
1433B_HUMANYAP1_HUMANBioGRID, DIP, IntAct, MINT17974916 19439659 20048001 24255178 24366813 25796446 27684187 28514442 30472188 31501420 details
1433B_HUMANSAP18_HUMANIntAct17353931 details
1433B_HUMANPYRG1_HUMANIntAct17353931 details
1433B_HUMANFOS_HUMANIntAct20195357 details
1433B_HUMANSRC8_HUMANMINT20363754 details
1433B_HUMANMARK2_HUMANBioGRID, HPRD, IntAct15324659 16959763 24255178 28514442 details
1433B_HUMANHDAC5_HUMANBioGRID, HPRD, IntAct10869435 21081666 23752268 24255178 28514442 details
1433B_HUMANPHB_HUMANBioGRID, MINT19725029 details
1433B_HUMANGP1BA_HUMANMINT19558434 details
1433B_HUMANZN395_HUMANIntAct, MINT17531190 28514442 details
1433B_HUMANHDAC7_HUMANBioGRID, IntAct17369396 23752268 24255178 28514442 details
1433B_HUMANMP2K2_HUMANBioGRID, IntAct10409742 24255178 31980649 details
1433B_HUMANSLIK1_HUMANMINT19640509 details
1433B_HUMANKIF1C_HUMANBioGRID, HPRD, IntAct10559254 24255178 28514442 details
1433B_HUMANCBX4_HUMANBioGRID, IntAct, UniProt21282530 22078878 details
1433B_HUMANAKTS1_HUMANBioGRID, IntAct, MINT18372248 24255178 28514442 details
1433B_HUMANPTN14_HUMANBioGRID, IntAct22948661 24255178 27432908 28514442 details
1433B_HUMANVIME_HUMANIntAct21112954 details
1433B_HUMANSPTN1_HUMANMINT20598904 details
1433B_HUMANKI13B_HUMANBioGRID, IntAct20194617 28514442 details
1433B_HUMANCHK1_HUMANMINT20639859 details
1433B_HUMANFOXO1_HUMANBioGRID, IntAct16919273 28514442 details
1433B_HUMANFA13A_HUMANIntAct28514442 31900205 details
1433B_HUMANTAU_HUMANBioGRID, HPRD, UniProt10840038 12176984 26269332 26402096 details
1433B_HUMANEMD_HUMANBioGRID17620012 details
1433B_HUMANITB2_HUMANBioGRID11700305 18239087 details
1433B_HUMANTRI32_HUMANBioGRID, IntAct23444366 24255178 details
1433B_HUMANKCNK9_HUMANBioGRID23772394 details
1433B_HUMANHNF1A_HUMANBioGRID18160415 details
1433B_HUMANGPR15_HUMANBioGRID23772394 details
1433B_HUMANKCJ11_HUMANBioGRID23772394 details
1433B_HUMANBCR_HUMANHPRD, IntAct16045749 28514442 details
1433B_HUMANSIK3_HUMANBioGRID22588126 details
1433B_HUMANBAP1_HUMANBioGRID29686263 details
1433B_HUMANDTL_HUMANBioGRID25154416 details
1433B_HUMANISG15_HUMANBioGRID33024031 details
1433B_HUMANDISC1_HUMANIntAct31413325 details
1433B_HUMANP53_HUMANBioGRID17898864 details
1433B_HUMANFER_HUMANHPRD15324660 details
1433B_HUMANNED4L_HUMANBioGRID20338996 details
1433B_HUMANKPCG_HUMANHPRD14676191 details
1433B_HUMANIKKB_HUMANHPRD16024783 details
1433B_HUMANMEX3B_HUMANBioGRID18779327 32460013 details
1433B_HUMANKPCD_HUMANHPRD16024783 details
1433B_HUMANRN115_HUMANBioGRID22315970 details
1433B_HUMANDAPK1_HUMANHPRD12911633 details
1433B_HUMANAGAP2_HUMANBioGRID30833542 details
1433B_HUMANSRC_HUMANHPRD8702721 details
1433B_HUMANRIN1_HUMANHPRD11784866 9144171 details
1433B_HUMANRGS7_HUMANHPRD10862767 details
1433B_HUMANPDCL2_HUMANHPRD12424248 details
1433B_HUMANMARK4_HUMANHPRD14676191 details
1433B_HUMANPAR6B_HUMANHPRD14676191 details
1433B_HUMANNAC2_HUMANHPRD16679322 details
1433B_HUMANTBB2A_HUMANHPRD15324660 details
1433B_HUMANDDIT4_HUMANBioGRID18198340 details
1433B_HUMANNAC3_HUMANHPRD16679322 details
1433B_HUMANPPARG_HUMANBioGRID26260846 details
1433B_HUMANTY3H_HUMANHPRD14675149 details
1433B_HUMANUB2E1_HUMANBioGRID31202814 details
1433B_HUMANNAC1_HUMANHPRD16679322 details
1433B_HUMANK1C18_HUMANHPRD9524113 details
1433B_HUMANSYUA_HUMANHPRD10407019 details