Entity Details

Primary name RORG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51449
EntryNameRORG_HUMAN
FullNameNuclear receptor ROR-gamma
TaxID9606
Evidenceevidence at protein level
Length518
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesRORC

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006805 xenobiotic metabolic process
GO:0008142 oxysterol binding
GO:0008270 zinc ion binding
GO:0010906 regulation of glucose metabolic process
GO:0016604 nuclear body
GO:0019218 regulation of steroid metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0032922 circadian regulation of gene expression
GO:0036315 cellular response to sterol
GO:0042093 T-helper cell differentiation
GO:0042753 positive regulation of circadian rhythm
GO:0045598 regulation of fat cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048535 lymph node development
GO:0048541 Peyer's patch development
GO:0060612 adipose tissue development
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0072539 T-helper 17 cell differentiation
GO:0098531 ligand-activated transcription factor activity
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003079 Nuclear receptor RORFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily
IPR044101 Retinoid-related orphan receptors, DNA-binding domainDomainDomain

Diseases

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Disease IDSourceNameDescription
616622 OMIMImmunodeficiency 42 (IMD42)An autosomal recessive primary immunodeficiency characterized by increased susceptibility to concomitant candidiasis and mycobacteriosis. Candidiasis is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida. Mycobacteriosis is characterized by infections caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. IMD42 patients vaccinated with BCG are particularly at risk for developing disseminated mycobacterial infections. The disease is caused by variants affecting the gene represented in this entry.

Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
RORG_HUMANEVI2A_HUMANBioGRID, IntAct21988832 details
RORG_HUMANBHE40_HUMANIntAct23555304 details
RORG_HUMANNR1D2_HUMANBioGRID, IntAct23555304 details
RORG_HUMANNPAS2_HUMANBioGRID, IntAct23555304 details
RORG_HUMANPP1G_HUMANBioGRID, IntAct23555304 details
RORG_HUMANPP1A_HUMANBioGRID, IntAct23555304 details
RORG_HUMAN2A5E_HUMANBioGRID, IntAct23555304 details
RORG_HUMAN2A5D_HUMANBioGRID, IntAct23555304 details
RORG_HUMAN2AAB_HUMANBioGRID, IntAct23555304 details
RORG_HUMANRORB_HUMANIntAct23555304 details
RORG_HUMAN2AAA_HUMANBioGRID, IntAct23555304 details
RORG_HUMANBMAL2_HUMANBioGRID, IntAct23555304 details
RORG_HUMANFXL15_HUMANBioGRID, IntAct23555304 details
RORG_HUMANPP1B_HUMANBioGRID, IntAct23555304 details
RORG_HUMANPP2AA_HUMANBioGRID, IntAct23555304 details
RORG_HUMANNCOA1_HUMANIntAct20203100 details
RORG_HUMANPRGC1_HUMANIntAct20203100 details
RORG_HUMANCBP_HUMANIntAct20203100 details
RORG_HUMANPRS8_HUMANBioGRID, IntAct15604093 32296183 details
RORG_HUMANNCOA6_HUMANBioGRID, HPRD15604093 details
RORG_HUMANCIPC_HUMANBioGRID23555304 details
RORG_HUMANKC1E_HUMANBioGRID23555304 details
RORG_HUMANBHE41_HUMANBioGRID23555304 details
RORG_HUMANPER2_HUMANBioGRID23555304 details
RORG_HUMANBMAL1_HUMANBioGRID23555304 details
RORG_HUMANCLOCK_HUMANBioGRID23555304 details
RORG_HUMANCHD4_HUMANHPRD15144897 details
RORG_HUMANFOXP3_HUMANDIP18368049 details
RORG_HUMANUBP4_HUMANBioGRID25821221 details
RORG_HUMANTRAF5_HUMANBioGRID26453305 details
RORG_HUMANEP300_HUMANBioGRID26549310 details
RORG_HUMANHDAC1_HUMANBioGRID26549310 details
RORG_HUMANSRC_HUMANBioGRID27430721 details
RORG_HUMANUBP15_HUMANBioGRID27430721 details
RORG_HUMANCUL4B_HUMANBioGRID30992047 details
RORG_HUMAN4EBP1_HUMANHPRD10405182 details