Entity Details

Primary name KCJ10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78508
EntryNameKCJ10_HUMAN
FullNameATP-sensitive inward rectifier potassium channel 10
TaxID9606
Evidenceevidence at protein level
Length379
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesKCNJ10

GO terms

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GOName
GO:0005242 inward rectifier potassium channel activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006813 potassium ion transport
GO:0007601 visual perception
GO:0007628 adult walking behavior
GO:0015272 ATP-activated inward rectifier potassium channel activity
GO:0016323 basolateral plasma membrane
GO:0022010 central nervous system myelination
GO:0034765 regulation of ion transmembrane transport
GO:0044297 cell body
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0051935 glutamate reuptake
GO:0055075 potassium ion homeostasis
GO:0060075 regulation of resting membrane potential
GO:0071805 potassium ion transmembrane transport
GO:0097449 astrocyte projection
GO:0098793 presynapse
GO:1901381 positive regulation of potassium ion transmembrane transport
GO:1990573 potassium ion import across plasma membrane

Subcellular Location

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Subcellular Location
Basolateral cell membrane
Membrane

Domains

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DomainNameCategoryType
IPR003269 Potassium channel, inwardly rectifying, Kir1.2FamilyFamily
IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmicFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR016449 Potassium channel, inwardly rectifying, KirFamilyFamily
IPR040445 Potassium channel, inwardly rectifying, transmembrane domainDomainDomain
IPR041647 Inward rectifier potassium channel, C-terminalDomainDomain

Diseases

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Disease IDSourceNameDescription
612780 OMIMSeizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SESAMES)A complex disorder characterized by generalized seizures with onset in infancy, delayed psychomotor development, ataxia, sensorineural hearing loss, hypokalemia, metabolic alkalosis, and hypomagnesemia. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01392 YohimbineDrugbanksmall molecule
DB11148 ButambenDrugbanksmall molecule