Entity Details

Primary name CLH1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ00610
EntryNameCLH1_HUMAN
FullNameClathrin heavy chain 1
TaxID9606
Evidenceevidence at protein level
Length1675
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesCLTC

GO terms

Show/Hide Table
GOName
GO:0000278 mitotic cell cycle
GO:0001649 osteoblast differentiation
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005198 structural molecule activity
GO:0005764 lysosome
GO:0005768 endosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006886 intracellular protein transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006898 receptor-mediated endocytosis
GO:0006914 autophagy
GO:0016020 membrane
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019901 protein kinase binding
GO:0030118 clathrin coat
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030132 clathrin coat of coated pit
GO:0030136 clathrin-coated vesicle
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031623 receptor internalization
GO:0032051 clathrin light chain binding
GO:0032588 trans-Golgi network membrane
GO:0032802 low-density lipoprotein particle receptor catabolic process
GO:0032991 protein-containing complex
GO:0033572 transferrin transport
GO:0034383 low-density lipoprotein particle clearance
GO:0036020 endolysosome membrane
GO:0042147 retrograde transport, endosome to Golgi
GO:0042470 melanosome
GO:0045334 clathrin-coated endocytic vesicle
GO:0048268 clathrin coat assembly
GO:0050750 low-density lipoprotein particle receptor binding
GO:0051301 cell division
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060236 regulation of mitotic spindle organization
GO:0061024 membrane organization
GO:0070062 extracellular exosome
GO:0071439 clathrin complex
GO:0072583 clathrin-dependent endocytosis
GO:0072686 mitotic spindle
GO:0097718 disordered domain specific binding
GO:0150093 amyloid-beta clearance by transcytosis
GO:1900126 negative regulation of hyaluronan biosynthetic process
GO:1903077 negative regulation of protein localization to plasma membrane
GO:1903561 extracellular vesicle
GO:1990381 ubiquitin-specific protease binding
GO:1990498 mitotic spindle microtubule

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Cytoplasmic vesicle membrane
Melanosome
Membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000547 Clathrin, heavy chain/VPS, 7-fold repeatRepeatRepeat
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR015348 Clathrin, heavy chain, linker, core motifDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR016025 Clathrin heavy chain, N-terminalFamilyHomologous superfamily
IPR016341 Clathrin, heavy chainFamilyFamily
IPR022365 Clathrin, heavy chain, propeller repeatRepeatRepeat

Diseases

Show/Hide Table
Disease IDSourceNameDescription
617854 OMIMMental retardation, autosomal dominant 56 (MRD56)A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. The disease is caused by variants affecting the gene represented in this entry.

Interactions

142 interactions

InteractorPartnerSourcesPublicationsLink
CLH1_HUMANXRCC6_HUMANBioGRID, HPRD, IntAct15383276 details
CLH1_HUMANACK1_HUMANBioGRID, HPRD, IntAct, MINT11278436 16137687 19798056 26496610 28739485 details
CLH1_HUMANPAAT_HUMANBioGRID, HPRD, IntAct16169070 26496610 28514442 details
CLH1_HUMANARMX3_HUMANBioGRID, HPRD, IntAct16169070 details
CLH1_HUMANOCRL_HUMANBioGRID, HPRD, IntAct, MINT15917292 16902405 19536138 25107275 26496610 details
CLH1_HUMANARRB1_HUMANBioGRID, HPRD, IntAct, MINT16709866 17620599 24502978 9169477 details
CLH1_HUMANTM1L1_HUMANBioGRID, MINT16412388 17785434 19798056 details
CLH1_HUMANKAPCA_HUMANBioGRID, IntAct20936779 details
CLH1_HUMANCLCA_HUMANBioGRID, HPRD, IntAct, MINT12426379 21297582 2406259 26344197 26496610 30021884 31672988 34079125 details
CLH1_HUMANSYQ_HUMANBioGRID, IntAct21988832 details
CLH1_HUMANEP300_HUMANBioGRID, IntAct21988832 26496610 details
CLH1_HUMANACOC_HUMANBioGRID, IntAct23414517 details
CLH1_HUMANOPTN_HUMANBioGRID, IntAct23414517 details
CLH1_HUMANPP1A_HUMANBioGRID, IntAct22321011 details
CLH1_HUMANHIP1_HUMANBioGRID, HPRD, IntAct11517213 11532990 11604514 11889126 15383276 22820750 23836884 25241761 26496610 details
CLH1_HUMANGCNT1_HUMANUniProt23027862 details
CLH1_HUMANCLCB_HUMANBioGRID, HPRD, IntAct12426379 15533940 21411634 26496610 34079125 details
CLH1_HUMANPICAL_HUMANBioGRID, HPRD, IntAct10436022 26496610 details
CLH1_HUMANAP2B1_HUMANBioGRID, IntAct10748223 17052248 26496610 details
CLH1_HUMANMYO6_HUMANBioGRID, IntAct11447109 26496610 26950368 31672988 details
CLH1_HUMANEPN4_HUMANBioGRID, HPRD, IntAct12429846 12538641 26496610 details
CLH1_HUMANSTABP_HUMANBioGRID, IntAct16431367 16716190 26496610 details
CLH1_HUMANHIP1R_HUMANBioGRID, HPRD, IntAct11889126 26496610 details
CLH1_HUMANAP2A2_HUMANBioGRID, IntAct17052248 26496610 9280305 details
CLH1_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
CLH1_HUMANHGS_HUMANBioGRID, HPRD11532964 16716190 21411634 28581508 details
CLH1_HUMANSNX5_HUMANBioGRID15133132 details
CLH1_HUMANTOM1_HUMANBioGRID, HPRD14563850 15657082 16412388 details
CLH1_HUMANAUXI_HUMANBioGRID, HPRD11470803 12732633 33957083 details
CLH1_HUMANEHD1_HUMANBioGRID11423532 26344197 details
CLH1_HUMANGGA1_HUMANBioGRID, HPRD11301005 17052248 17344219 17506864 details
CLH1_HUMANGGA2_HUMANBioGRID, HPRD11301005 11387476 17344219 31076515 details
CLH1_HUMANGGA3_HUMANBioGRID, HPRD11301005 details
CLH1_HUMANAMPH_HUMANBioGRID, HPRD10748223 9195986 9280305 9603201 details
CLH1_HUMANARH_HUMANBioGRID, HPRD12221107 details
CLH1_HUMANAP1B1_HUMANBioGRID, HPRD11451993 9280305 details
CLH1_HUMANAP3B2_HUMANBioGRID, HPRD9545220 details
CLH1_HUMANEPN2_HUMANBioGRID, HPRD10567358 details
CLH1_HUMANVINC_HUMANBioGRID, HPRD8276759 details
CLH1_HUMANSTAM1_HUMANBioGRID16431367 16716190 29604273 details
CLH1_HUMANWNK1_HUMANBioGRID20936779 26496610 details
CLH1_HUMANITSN1_HUMANBioGRID22558309 details
CLH1_HUMANAP1G1_HUMANBioGRID, HPRD11387476 11451993 17052248 21411634 details
CLH1_HUMANHERC1_HUMANBioGRID9233772 details
CLH1_HUMANSYNJ1_HUMANBioGRID12057195 details
CLH1_HUMANSRC_HUMANBioGRID17785434 details
CLH1_HUMANFYN_HUMANBioGRID17785434 details
CLH1_HUMANPP1G_HUMANBioGRID23080069 details
CLH1_HUMANARRB2_HUMANBioGRID, HPRD10097102 17666399 9169477 details
CLH1_HUMANPTAFR_HUMANBioGRID16709866 22707565 details
CLH1_HUMAN1433T_HUMANBioGRID15161933 details
CLH1_HUMANERG_HUMANBioGRID24591637 details
CLH1_HUMANZFYV9_HUMANBioGRID23222715 details
CLH1_HUMANSMAP1_HUMANBioGRID15659652 details
CLH1_HUMANSUMO2_HUMANBioGRID32786267 details
CLH1_HUMANAFTIN_HUMANBioGRID15758025 details
CLH1_HUMANCLH1_HUMANHPRD11532990 12426379 12952949 details
CLH1_HUMANM3K8_HUMANIntAct14743216 details
CLH1_HUMANREL_HUMANIntAct14743216 details
CLH1_HUMANIKBA_HUMANIntAct14743216 details
CLH1_HUMANIKBB_HUMANIntAct14743216 details
CLH1_HUMANIKBE_HUMANIntAct14743216 details
CLH1_HUMANIKKA_HUMANIntAct14743216 details
CLH1_HUMANIKKB_HUMANBioGRID, IntAct14743216 25241761 details
CLH1_HUMANIKKE_HUMANBioGRID, IntAct14743216 17353931 details
CLH1_HUMANNEMO_HUMANIntAct14743216 details
CLH1_HUMANTANK_HUMANIntAct14743216 details
CLH1_HUMANM3K3_HUMANIntAct14743216 details
CLH1_HUMANNFKB2_HUMANIntAct14743216 details
CLH1_HUMANTF65_HUMANIntAct14743216 details
CLH1_HUMANRELB_HUMANIntAct14743216 details
CLH1_HUMANRIPK3_HUMANIntAct14743216 details
CLH1_HUMANTAB2_HUMANIntAct14743216 details
CLH1_HUMANM3K7_HUMANBioGRID, IntAct14743216 25241761 details
CLH1_HUMANTNR1A_HUMANIntAct14743216 details
CLH1_HUMANTNR1B_HUMANIntAct14743216 details
CLH1_HUMANTRADD_HUMANIntAct14743216 details
CLH1_HUMANTRAF2_HUMANIntAct14743216 details
CLH1_HUMANBCR_HUMANMINT15494376 details
CLH1_HUMANHLAC_HUMANIntAct17353931 details
CLH1_HUMANAAKB1_HUMANIntAct17353931 details
CLH1_HUMAN1433Z_HUMANMINT15161933 details
CLH1_HUMANMYB_HUMANMINT18548008 details
CLH1_HUMANGCR_HUMANIntAct20195357 details
CLH1_HUMANMLP3A_HUMANBioGRID, IntAct20562859 22963397 24067654 details
CLH1_HUMANUBC9_HUMANIntAct20936779 details
CLH1_HUMANSF01_HUMANIntAct26420826 details
CLH1_HUMANSCYL2_HUMANBioGRID, HPRD, IntAct1589293 25852190 details
CLH1_HUMANDAB2_HUMANBioGRID, IntAct22323290 26496610 details
CLH1_HUMANSTALP_HUMANBioGRID, IntAct16716190 26496610 28514442 details
CLH1_HUMANEPS15_HUMANBioGRID, IntAct18524853 26496610 details
CLH1_HUMANMARF1_HUMANBioGRID, IntAct26496610 29395067 details
CLH1_HUMANGAK_HUMANBioGRID, HPRD, IntAct12732633 26496610 33957083 details
CLH1_HUMANEPN1_HUMANBioGRID, HPRD, IntAct10692452 26496610 details
CLH1_HUMANADA1A_HUMANIntAct23460120 details
CLH1_HUMANDISC1_HUMANIntAct31413325 details
CLH1_HUMANMIPT3_HUMANIntAct31413325 details
CLH1_HUMANFMR1_HUMANIntAct31413325 details
CLH1_HUMANFAK2_HUMANIntAct31413325 details
CLH1_HUMANPAXI_HUMANBioGRID, HPRD, IntAct10330411 31980649 details
CLH1_HUMANSNX9_HUMANBioGRID, HPRD11799118 12952949 details
CLH1_HUMANKIT_HUMANBioGRID, HPRD10477727 details
CLH1_HUMANM3K10_HUMANBioGRID, HPRD12105200 details
CLH1_HUMANSYUA_HUMANBioGRID18614564 details
CLH1_HUMANHDAC5_HUMANBioGRID21081666 details
CLH1_HUMANRICTR_HUMANBioGRID17461779 details
CLH1_HUMANPCM1_HUMANBioGRID21956701 details
CLH1_HUMANDYR1A_HUMANBioGRID19722700 details
CLH1_HUMANAP180_HUMANBioGRID10748223 details
CLH1_HUMANBIN1_HUMANBioGRID9195986 details
CLH1_HUMANRAC1_HUMANBioGRID21291504 details
CLH1_HUMANTM1L2_HUMANBioGRID16412388 details
CLH1_HUMANISG15_HUMANBioGRID16009940 33024031 details
CLH1_HUMANA16L1_HUMANBioGRID20639872 29360461 30196744 details
CLH1_HUMANAKT1_HUMANBioGRID16027165 details
CLH1_HUMANITA4_HUMANBioGRID22623428 details
CLH1_HUMANMYBB_HUMANBioGRID18548008 details
CLH1_HUMANSVIL_HUMANBioGRID, HPRD12202484 details
CLH1_HUMANATP4A_HUMANBioGRID17255364 details
CLH1_HUMANEPHA2_HUMANBioGRID23874206 details
CLH1_HUMANP53_HUMANBioGRID25144556 29653964 32807901 details
CLH1_HUMANCXB5_HUMANBioGRID25388970 details
CLH1_HUMANADRB2_HUMANBioGRID12163475 23236378 details
CLH1_HUMANV2R_HUMANBioGRID23236378 details
CLH1_HUMANAP3D1_HUMANBioGRID21411634 details
CLH1_HUMANU2AF2_HUMANBioGRID26641092 details
CLH1_HUMANARF6_HUMANBioGRID16413285 details
CLH1_HUMANPGFRB_HUMANBioGRID23836884 details
CLH1_HUMANSTX2_HUMANBioGRID29360461 details
CLH1_HUMANCXA1_HUMANBioGRID24705551 details
CLH1_HUMANANR55_HUMANBioGRID31620119 details
CLH1_HUMANMRP2_HUMANBioGRID31316180 details
CLH1_HUMANKPCB_HUMANBioGRID31634457 details
CLH1_HUMANEPHA3_HUMANBioGRID31577226 details
CLH1_HUMANEIF3H_HUMANBioGRID32269044 details
CLH1_HUMANARRC_HUMANHPRD11877451 9827808 details
CLH1_HUMANNMDE4_HUMANHPRD10862698 details
CLH1_HUMANAP3B1_HUMANHPRD9545220 details
CLH1_HUMANNCALD_HUMANHPRD11964161 details
CLH1_HUMANNMDZ1_HUMANHPRD10862698 details
CLH1_HUMANAP2A_HUMANHPRD1587861 details
CLH1_HUMAN1433G_HUMANHPRD15324660 details