Entity Details

Primary name SOS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ07890
EntryNameSOS2_HUMAN
FullNameSon of sevenless homolog 2
TaxID9606
Evidenceevidence at protein level
Length1332
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesSOS2

GO terms

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GOName
GO:0001782 B cell homeostasis
GO:0003677 DNA binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005829 cytosol
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0033081 regulation of T cell differentiation in thymus
GO:0042129 regulation of T cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0046982 protein heterodimerization activity
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:2000973 regulation of pro-B cell differentiation

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminalDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR007125 Histone H2A/H2B/H3DomainDomain
IPR008937 Ras-like guanine nucleotide exchange factorFamilyFamily
IPR009072 Histone-foldFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR019804 Ras guanine-nucleotide exchange factor, conserved siteSiteConserved site
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616559 OMIMNoonan syndrome 9 (NS9)A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. The disease is caused by variants affecting the gene represented in this entry.

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
SOS2_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT10940929 14679214 17474147 19380743 20936779 21706016 21988832 28514442 31980649 32062451 32203420 7629138 details
SOS2_HUMANPLCG1_HUMANBioGRID, HPRD, IntAct10940929 17474147 details
SOS2_HUMANABL1_HUMANHPRD, IntAct14679214 17474147 details
SOS2_HUMANCRK_HUMANBioGRID, IntAct17474147 19380743 details
SOS2_HUMANSRC_HUMANIntAct17474147 details
SOS2_HUMANFYN_HUMANIntAct17474147 details
SOS2_HUMANNCK1_HUMANIntAct17474147 details
SOS2_HUMANP85A_HUMANIntAct17474147 details
SOS2_HUMANEGFR_HUMANBioGRID, HPRD, IntAct10675333 18271526 19531499 23956138 24658140 24797263 25402006 31959764 31980649 details
SOS2_HUMANLYOX_HUMANmatrixdb25118846 details
SOS2_HUMANGRAP2_HUMANBioGRID, HPRD10820259 details
SOS2_HUMANITSN2_HUMANBioGRID22558309 details
SOS2_HUMANBIN1_HUMANBioGRID9182529 details
SOS2_HUMANCBP_HUMANBioGRID32238831 details
SOS2_HUMANSH319_HUMANHPRD14551139 details
SOS2_HUMANPACN3_HUMANHPRD, IntAct14679214 details
SOS2_HUMANSNX9_HUMANHPRD, IntAct14679214 details
SOS2_HUMANCD2AP_HUMANHPRD, IntAct14679214 details
SOS2_HUMANSNX18_HUMANHPRD, IntAct14679214 details
SOS2_HUMANRXRB_HUMANIntAct20195357 details
SOS2_HUMANCLUS_HUMANIntAct31413325 details
SOS2_HUMANGRB7_HUMANIntAct29290818 details
SOS2_HUMANRASK_HUMANIntAct29290818 details
SOS2_HUMANSHC1_HUMANBioGRID, HPRD10675333 19380743 details
SOS2_HUMANESR1_HUMANBioGRID15173068 details
SOS2_HUMANLRRK1_HUMANBioGRID20697350 details
SOS2_HUMANRASH_HUMANHPRD12628188 details
SOS2_HUMANABI1_HUMANHPRD11003655 details
SOS2_HUMANCRKL_HUMANHPRD8943292 details