Entity Details

Primary name CHD3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12873
EntryNameCHD3_HUMAN
FullNameChromodomain-helicase-DNA-binding protein 3
TaxID9606
Evidenceevidence at protein level
Length2000
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesCHD3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003723 RNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0006333 chromatin assembly or disassembly
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007051 spindle organization
GO:0007098 centrosome cycle
GO:0008270 zinc ion binding
GO:0016581 NuRD complex
GO:0016605 PML body
GO:0016887 ATP hydrolysis activity
GO:0034451 centriolar satellite
GO:0036121 double-stranded DNA helicase activity
GO:0043044 ATP-dependent chromatin remodeling
GO:0070615 nucleosome-dependent ATPase activity
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000330 SNF2, N-terminalDomainDomain
IPR000953 Chromo/chromo shadow domainDomainDomain
IPR001650 Helicase, C-terminalDomainDomain
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved siteSiteConserved site
IPR009462 Domain of unknown function DUF1086DomainDomain
IPR009463 Domain of unknown function DUF1087DomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR012957 CHD, C-terminal 2DomainDomain
IPR012958 CHD, N-terminalDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR016197 Chromo-like domain superfamilyFamilyHomologous superfamily
IPR019786 Zinc finger, PHD-type, conserved siteSiteConserved site
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR023779 Chromo domain, conserved siteSiteConserved site
IPR023780 Chromo domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily
IPR038718 SNF2-like, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618205 OMIMSnijders Blok-Campeau syndrome (SNIBCPS)An autosomal dominant neurodevelopmental disorder characterized by intellectual disability with a wide range of severity, developmental delay, and impaired speech and language skills. Speech-related problems include dysarthria, speech apraxia, oromotor problems, and stuttering. Additional clinical features are macrocephaly, characteristic facial features such as prominent forehead and hypertelorism, hypotonia, and joint laxity. The disease is caused by variants affecting the gene represented in this entry.

Interactions

139 interactions

InteractorPartnerSourcesPublicationsLink
CHD3_HUMANHD_HUMANBioGRID, HPRD, IntAct15383276 details
CHD3_HUMANGIT1_HUMANBioGRID, HPRD, IntAct15383276 details
CHD3_HUMANBARD1_HUMANBioGRID, IntAct15383276 details
CHD3_HUMANPR40A_HUMANBioGRID, HPRD, IntAct15383276 28977666 details
CHD3_HUMANSUMO2_HUMANBioGRID, HPRD, IntAct, MINT15383276 16169070 21900206 24018422 32786267 details
CHD3_HUMANVIME_HUMANBioGRID, HPRD, IntAct15383276 28977666 details
CHD3_HUMANCHD3_HUMANBioGRID, HPRD, IntAct10204490 15383276 28977666 9885572 details
CHD3_HUMANLRIF1_HUMANBioGRID, HPRD, IntAct15383276 details
CHD3_HUMANPIAS4_HUMANBioGRID, HPRD, IntAct15383276 details
CHD3_HUMANZHX1_HUMANBioGRID, HPRD, IntAct15383276 details
CHD3_HUMANNFL_HUMANBioGRID, HPRD, IntAct15383276 details
CHD3_HUMANTCRG1_HUMANBioGRID, HPRD, IntAct15383276 details
CHD3_HUMANPTN_HUMANBioGRID, HPRD, IntAct15383276 16169070 details
CHD3_HUMANIMB1_HUMANBioGRID, HPRD, IntAct15383276 details
CHD3_HUMANTALDO_HUMANIntAct15383276 details
CHD3_HUMANMIC60_HUMANBioGRID, HPRD, IntAct15383276 16169070 details
CHD3_HUMANPAIRB_HUMANBioGRID, HPRD, IntAct12505151 16169070 28977666 details
CHD3_HUMANHABP4_HUMANBioGRID, HPRD, IntAct12505151 16169070 16455055 details
CHD3_HUMANSKIL_HUMANBioGRID, MINT15231748 details
CHD3_HUMANCSTF2_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANTXND9_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANBHE40_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANCREB1_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANFUBP1_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANRAD51_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANPUF60_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANSIR6_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
CHD3_HUMANSRRT_HUMANBioGRID, HPRD, IntAct16169070 28977666 details
CHD3_HUMANRETR2_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANYAE1_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
CHD3_HUMANGPS2_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANRED_HUMANBioGRID, HPRD, IntAct16169070 28977666 details
CHD3_HUMANKIF15_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANLC7L2_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANMAFG_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANMA2A2_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANCRCT1_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANPUR6_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANPSME1_HUMANBioGRID, IntAct16169070 details
CHD3_HUMANRL29_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANSAFB1_HUMANBioGRID, HPRD, IntAct16169070 28977666 details
CHD3_HUMANTIF1B_HUMANBioGRID, DIP, HPRD, IntAct16169070 18082607 21642969 24018422 28977666 details
CHD3_HUMANTTHY_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
CHD3_HUMANCASP8_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANCBPE_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANCD017_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANNS1BP_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANTHOC7_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANPRG2_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANPTPRS_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANSGSM2_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANSAT1_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANENTR1_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANTNR14_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANUBA3_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANXRCC4_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANADHX_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANATIF1_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANCASP6_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANF16P2_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANHS105_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANPIMT_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANSERF2_HUMANBioGRID, IntAct16169070 details
CHD3_HUMANTSN6_HUMANBioGRID, HPRD, IntAct16169070 details
CHD3_HUMANACTY_HUMANHPRD, IntAct16169070 details
CHD3_HUMANCTBP1_HUMANBioGRID, MINT21900206 details
CHD3_HUMANFABP4_HUMANBioGRID, MINT21900206 details
CHD3_HUMANGA45A_HUMANBioGRID, MINT21900206 details
CHD3_HUMANGSK3B_HUMANBioGRID, MINT21900206 details
CHD3_HUMANHCD2_HUMANBioGRID, MINT21900206 details
CHD3_HUMANAIMP2_HUMANBioGRID, MINT21900206 details
CHD3_HUMANNR1H2_HUMANBioGRID, MINT21900206 details
CHD3_HUMANNR4A1_HUMANBioGRID, MINT21900206 details
CHD3_HUMANPLK4_HUMANBioGRID, MINT21900206 details
CHD3_HUMANRGS2_HUMANBioGRID, MINT21900206 details
CHD3_HUMANTNNT1_HUMANBioGRID, MINT21900206 details
CHD3_HUMANT22D1_HUMANBioGRID, MINT21900206 details
CHD3_HUMANDCUP_HUMANBioGRID, MINT21900206 details
CHD3_HUMANSETX_HUMANUniProt24244371 details
CHD3_HUMANCHM4B_HUMANIntAct16730941 details
CHD3_HUMANIKZF1_HUMANBioGRID, HPRD, IntAct10204490 28514442 30760870 details
CHD3_HUMANTAL1_HUMANBioGRID, DIP, HPRD15383276 19497860 details
CHD3_HUMANSUMO1_HUMANBioGRID, DIP, HPRD10961991 14609633 21642969 details
CHD3_HUMANZBT7A_HUMANBioGRID, DIP23658227 26816381 details
CHD3_HUMANH31_HUMANBioGRID, IntAct11850410 16728976 25533843 29020631 29568061 34079125 details
CHD3_HUMANMBD2_HUMANBioGRID, IntAct10444591 11297506 24981860 28977666 details
CHD3_HUMANUBC9_HUMANBioGRID, HPRD14609633 details
CHD3_HUMANP53_HUMANBioGRID, HPRD10961991 15383276 details
CHD3_HUMANP73_HUMANBioGRID, HPRD10961991 details
CHD3_HUMANSRC8_HUMANBioGRID, HPRD16169070 details
CHD3_HUMANS27A6_HUMANBioGRID, HPRD16169070 details
CHD3_HUMANBCL6_HUMANBioGRID15454082 details
CHD3_HUMANPCNT_HUMANBioGRID17626165 details
CHD3_HUMANMYB_HUMANBioGRID17344210 details
CHD3_HUMANUBC_HUMANBioGRID23314748 details
CHD3_HUMANMX1_HUMANBioGRID25447205 details
CHD3_HUMANSPOP_HUMANBioGRID28805822 29996942 details
CHD3_HUMANIMA1_HUMANBioGRID, HPRD15383276 28977666 details
CHD3_HUMANSENP1_HUMANBioGRID30082317 details
CHD3_HUMANCBP_HUMANBioGRID28680062 details
CHD3_HUMANTRI54_HUMANBioGRID31391242 details
CHD3_HUMANZBED1_HUMANBioGRID27068747 details
CHD3_HUMANPIAS1_HUMANBioGRID27068747 details
CHD3_HUMANCBX4_HUMANBioGRID27068747 details
CHD3_HUMANRIF1_HUMANHPRD15383276 details
CHD3_HUMANADT3_HUMANBioGRID, IntAct16169070 28977666 details
CHD3_HUMANMTA2_HUMANBioGRID, IntAct10444591 11297506 19703393 22939629 24981860 26344197 28977666 details
CHD3_HUMANKDM1A_HUMANBioGRID, IntAct19703393 21937684 details
CHD3_HUMANSP1_HUMANIntAct20195357 details
CHD3_HUMANDDX5_HUMANBioGRID, I2D20676135 28977666 details
CHD3_HUMANHDAC1_HUMANBioGRID, IntAct11784859 17827154 20585571 22939629 23752268 26496610 27068747 28514442 28977666 9804427 9885572 details
CHD3_HUMANHDAC2_HUMANBioGRID, IntAct, MINT12198550 12493763 17827154 22939629 23752268 24981860 26949739 28977666 30737378 9804427 9885572 details
CHD3_HUMANRBBP4_HUMANBioGRID, IntAct, MINT22939629 24981860 27705803 28977666 9885572 details
CHD3_HUMANRBBP7_HUMANBioGRID, IntAct22939629 26186194 27705803 28514442 28977666 details
CHD3_HUMANJUN_HUMANBioGRID, MINT21196933 25609649 details
CHD3_HUMANMB3L1_HUMANBioGRID, IntAct15456747 26186194 28514442 details
CHD3_HUMANSMCA5_HUMANBioGRID, IntAct12198550 24981860 28977666 details
CHD3_HUMANMTA1_HUMANBioGRID, IntAct12431981 17922035 24981860 26344197 28977666 9885572 details
CHD3_HUMANMTA3_HUMANBioGRID, IntAct12705869 24981860 26344197 28977666 details
CHD3_HUMANCHD4_HUMANBioGRID, IntAct22939629 24981860 28977666 9885572 details
CHD3_HUMANRAD21_HUMANBioGRID12198550 details
CHD3_HUMANCHD6_HUMANBioGRID17027977 details
CHD3_HUMANNAB2_HUMANBioGRID16574654 details
CHD3_HUMANSIN3A_HUMANBioGRID12453419 24981860 details
CHD3_HUMANSMCA2_HUMANBioGRID12453419 28977666 details
CHD3_HUMANTAF6_HUMANBioGRID12453419 details
CHD3_HUMANHSF1_HUMANBioGRID17922035 details
CHD3_HUMANCSK21_HUMANBioGRID17827154 details
CHD3_HUMANHIC1_HUMANBioGRID20547755 details
CHD3_HUMANKDM5B_HUMANBioGRID21937684 details
CHD3_HUMANTWST1_HUMANBioGRID22457607 details
CHD3_HUMANPHF6_HUMANBioGRID22720776 details
CHD3_HUMANKMT2A_HUMANBioGRID12453419 details
CHD3_HUMANSATB1_HUMANBioGRID, HPRD12374985 details
CHD3_HUMANH2B1B_HUMANBioGRID25533843 27248496 details
CHD3_HUMANHYPK_HUMANBioGRID23272104 details
CHD3_HUMANBRD1_HUMANBioGRID27142060 details
CHD3_HUMANBCOR_HUMANBioGRID23658227 details
CHD3_HUMANIKZF3_HUMANBioGRID, HPRD10204490 30760870 details