Entity Details

Primary name EPS8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12929
EntryNameEPS8_HUMAN
FullNameEpidermal growth factor receptor kinase substrate 8
TaxID9606
Evidenceevidence at protein level
Length822
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesEPS8

GO terms

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GOName
GO:0003779 actin binding
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0007266 Rho protein signal transduction
GO:0008360 regulation of cell shape
GO:0010458 exit from mitosis
GO:0016601 Rac protein signal transduction
GO:0030426 growth cone
GO:0030832 regulation of actin filament length
GO:0031267 small GTPase binding
GO:0031982 vesicle
GO:0032420 stereocilium
GO:0032587 ruffle membrane
GO:0035023 regulation of Rho protein signal transduction
GO:0035591 signaling adaptor activity
GO:0036336 dendritic cell migration
GO:0045202 synapse
GO:0051016 barbed-end actin filament capping
GO:0051017 actin filament bundle assembly
GO:0051764 actin crosslink formation
GO:0070062 extracellular exosome
GO:0070358 actin polymerization-dependent cell motility
GO:1900029 positive regulation of ruffle assembly

Subcellular Location

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Subcellular Location
Cell junction
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR006020 PTB/PI domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR013625 Tensin/EPS8 phosphotyrosine-binding domainDomainDomain
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR030222 Epidermal growth factor receptor kinase substrate 8FamilyFamily
IPR033928 Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domainDomainDomain
IPR035462 Eps8, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR039801 Epidermal growth factor receptor kinase substrate 8-likeFamilyFamily
IPR041418 SAM domainDomainDomain

Diseases

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Disease IDSourceNameDescription
615974 OMIMDeafness, autosomal recessive, 102 (DFNB102)A form of non-syndromic deafness characterized by profound hearing loss affecting all frequencies. Vestibular function is unaffected. The disease is caused by variants affecting the gene represented in this entry.

Interactions

65 interactions

InteractorPartnerSourcesPublicationsLink
EPS8_HUMANITB5_HUMANHPRD, MINT12606711 details
EPS8_HUMANITB3_HUMANHPRD, MINT12606711 details
EPS8_HUMANBAIP2_HUMANBioGRID, DIP, HPRD, IntAct, MINT15289329 16189514 19564905 24076653 24584464 25416956 25814554 26186194 28514442 details
EPS8_HUMANRM20_HUMANBioGRID, HPRD, IntAct16169070 details
EPS8_HUMANMYO15_HUMANBioGRID, HPRD, IntAct16169070 details
EPS8_HUMANIDLC_HUMANBioGRID, HPRD, IntAct16169070 details
EPS8_HUMANBL1S6_HUMANBioGRID, HPRD, IntAct16189514 details
EPS8_HUMANCC85B_HUMANBioGRID, HPRD, IntAct16189514 details
EPS8_HUMANAIMP2_HUMANBioGRID, HPRD, IntAct16189514 details
EPS8_HUMANPCM1_HUMANBioGRID, HPRD, IntAct16189514 details
EPS8_HUMANHOOK2_HUMANBioGRID, HPRD, IntAct16189514 details
EPS8_HUMANTEX28_HUMANBioGRID, HPRD, IntAct16189514 details
EPS8_HUMANEPS8_HUMANBioGRID, HPRD, IntAct10499589 16189514 8700515 9010225 9303002 details
EPS8_HUMANTYDP2_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANAL7A1_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANCSK2B_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANCXCL2_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANXRCC6_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANM3K11_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANNFKB2_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANRFXAP_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANBCKD_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANS27A4_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANSF3B3_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANZZZ3_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANCTNA3_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANGULP1_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANADA22_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANARMC1_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANSCRN3_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANNACC2_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANPRSR2_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANTPRN_HUMANBioGRID, IntAct21988832 details
EPS8_HUMANCH033_HUMANBioGRID, MINT21900206 details
EPS8_HUMANMLP3B_HUMANBioGRID, MINT21900206 details
EPS8_HUMANXAGE2_HUMANBioGRID, IntAct25814554 details
EPS8_HUMANCBL_HUMANBioGRID, IntAct25814554 27629044 details
EPS8_HUMANCF141_HUMANBioGRID, IntAct25814554 details
EPS8_HUMANRCAN3_HUMANBioGRID, IntAct25814554 details
EPS8_HUMANRSP14_HUMANBioGRID, IntAct25814554 details
EPS8_HUMANIPSP_HUMANBioGRID, IntAct25814554 details
EPS8_HUMANEGFR_HUMANBioGRID, HPRD, IntAct11408594 12127568 24658140 25402006 31980649 7532293 details
EPS8_HUMANHNRPC_HUMANBioGRID, IntAct25416956 details
EPS8_HUMANGRB2_HUMANBioGRID, IntAct25416956 details
EPS8_HUMANMTG8_HUMANBioGRID, IntAct25416956 details
EPS8_HUMANGOG8D_HUMANIntAct25416956 details
EPS8_HUMANBYST_HUMANBioGRID, IntAct25416956 details
EPS8_HUMANPI5PA_HUMANBioGRID, IntAct25416956 details
EPS8_HUMANSMCE1_HUMANBioGRID, IntAct25416956 details
EPS8_HUMANBORC6_HUMANBioGRID, IntAct25416956 details
EPS8_HUMANCS025_HUMANBioGRID, IntAct25416956 details
EPS8_HUMANBI2L1_HUMANBioGRID, DIP21098279 22921828 details
EPS8_HUMANDVL1_HUMANBioGRID, HPRD10581192 details
EPS8_HUMANABI1_HUMANBioGRID, HPRD1049958 10499589 11099046 12127568 14565974 15289329 9010225 details
EPS8_HUMANSHC1_HUMANBioGRID, HPRD7791787 details
EPS8_HUMANSRC_HUMANBioGRID, HPRD10395945 details
EPS8_HUMANSHB_HUMANBioGRID, HPRD7537362 details
EPS8_HUMANITSN2_HUMANBioGRID22449706 details
EPS8_HUMANUS6NL_HUMANHPRD, MINT11099046 8700527 details
EPS8_HUMANITB1_HUMANMINT12606711 details
EPS8_HUMANCSKP_HUMANHPRD, MINT16688213 details
EPS8_HUMANSOS1_HUMANBioGRID, HPRD, MINT10499589 14565974 16520382 27629044 details
EPS8_HUMANCD3E_HUMANMINT17617578 details
EPS8_HUMANFBXW5_HUMANDIP23314863 details
EPS8_HUMANACTS_HUMANHPRD11524436 12127568 details