Entity Details

Primary name POLQ
Entity type gene
Source Source Link

Details

PrimaryID10721
RefseqGene
SymbolPOLQ
NameDNA polymerase theta
Chromosome3
Location3q13.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-09-20
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsDPOLQ_HUMAN

GO terms

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GOName
GO:0000724 double-strand break repair via homologous recombination
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006302 double-strand break repair
GO:0006974 cellular response to DNA damage stimulus
GO:0008409 5'-3' exonuclease activity
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0017116 single-stranded DNA helicase activity
GO:0042802 identical protein binding
GO:0051260 protein homooligomerization
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
GO:0097681 double-strand break repair via alternative nonhomologous end joining
GO:2000042 negative regulation of double-strand break repair via homologous recombination

Diseases

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Disease IDSourceNameDescription
114480 OMIMBreast cancer (BC)A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. The gene represented in this entry may be involved in disease pathogenesis.

Interactions

7 interactions