Entity Details

Primary name VCAN
Entity type gene
Source Source Link

Details

PrimaryID1462
RefseqGeneNG_012682
SymbolVCAN
Nameversican
Chromosome5
Location5q14.2-q14.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1993-01-13
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsCSPG2_HUMAN

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001750 photoreceptor outer segment
GO:0005509 calcium ion binding
GO:0005539 glycosaminoglycan binding
GO:0005540 hyaluronic acid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0007155 cell adhesion
GO:0007275 multicellular organism development
GO:0007417 central nervous system development
GO:0008037 cell recognition
GO:0008347 glial cell migration
GO:0016020 membrane
GO:0030021 extracellular matrix structural constituent conferring compression resistance
GO:0030198 extracellular matrix organization
GO:0030206 chondroitin sulfate biosynthetic process
GO:0030207 chondroitin sulfate catabolic process
GO:0030208 dermatan sulfate biosynthetic process
GO:0030246 carbohydrate binding
GO:0031012 extracellular matrix
GO:0033165 interphotoreceptor matrix
GO:0043202 lysosomal lumen
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0062023 collagen-containing extracellular matrix

Diseases

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Disease IDSourceNameDescription
143200 OMIMWagner vitreoretinopathy (WGVRP)A rare vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. The disease is caused by variants affecting the gene represented in this entry. The pathological mechanism involves a quantitative imbalance of the normally occurring splice variants (PubMed:22739342).