Entity Details

Primary name SEM3A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14563
EntryNameSEM3A_HUMAN
FullNameSemaphorin-3A
TaxID9606
Evidenceevidence at protein level
Length771
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesSEMA3A

GO terms

Show/Hide Table
GOName
GO:0001755 neural crest cell migration
GO:0001764 neuron migration
GO:0002027 regulation of heart rate
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0006915 apoptotic process
GO:0007411 axon guidance
GO:0007413 axonal fasciculation
GO:0008045 motor neuron axon guidance
GO:0010633 negative regulation of epithelial cell migration
GO:0010977 negative regulation of neuron projection development
GO:0021612 facial nerve structural organization
GO:0021637 trigeminal nerve structural organization
GO:0021675 nerve development
GO:0021772 olfactory bulb development
GO:0021785 branchiomotor neuron axon guidance
GO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO:0030215 semaphorin receptor binding
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0036486 ventral trunk neural crest cell migration
GO:0038191 neuropilin binding
GO:0045499 chemorepellent activity
GO:0046330 positive regulation of JNK cascade
GO:0048485 sympathetic nervous system development
GO:0048841 regulation of axon extension involved in axon guidance
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0048846 axon extension involved in axon guidance
GO:0048880 sensory system development
GO:0050919 negative chemotaxis
GO:0060385 axonogenesis involved in innervation
GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching
GO:0061549 sympathetic ganglion development
GO:0061551 trigeminal ganglion development
GO:0071526 semaphorin-plexin signaling pathway
GO:0097490 sympathetic neuron projection extension
GO:0097491 sympathetic neuron projection guidance
GO:0150020 basal dendrite arborization
GO:1901166 neural crest cell migration involved in autonomic nervous system development
GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance
GO:1903045 neural crest cell migration involved in sympathetic nervous system development
GO:1903375 facioacoustic ganglion development
GO:2000020 positive regulation of male gonad development
GO:2001224 positive regulation of neuron migration

Subcellular Location

Show/Hide Table
Subcellular Location
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR001627 Sema domainDomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR016201 PSI domainDomainDomain
IPR027231 SemaphorinFamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR036352 Sema domain superfamilyFamilyHomologous superfamily
IPR042820 Semaphorin-3A, sema domainDomainDomain

Diseases

Show/Hide Table
Disease IDSourceNameDescription
614897 OMIMHypogonadotropic hypogonadism 16 with or without anosmia (HH16)A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). The disease may be caused by variants affecting distinct genetic loci, including the gene represented in this entry.

Interactions

3 interactions