Entity Details

Primary name NECT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15223
EntryNameNECT1_HUMAN
FullNameNectin-1
TaxID9606
Evidenceevidence at protein level
Length517
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesNECTIN1

GO terms

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GOName
GO:0001618 virus receptor activity
GO:0002089 lens morphogenesis in camera-type eye
GO:0002934 desmosome organization
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0006826 iron ion transport
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007411 axon guidance
GO:0015026 coreceptor activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019062 virion attachment to host cell
GO:0030246 carbohydrate binding
GO:0030425 dendrite
GO:0032584 growth cone membrane
GO:0034332 adherens junction organization
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043231 intracellular membrane-bounded organelle
GO:0043296 apical junction complex
GO:0044291 cell-cell contact zone
GO:0044877 protein-containing complex binding
GO:0046718 viral entry into host cell
GO:0046790 virion binding
GO:0050839 cell adhesion molecule binding
GO:0051963 regulation of synapse assembly
GO:0060041 retina development in camera-type eye
GO:0070166 enamel mineralization
GO:0098609 cell-cell adhesion
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0099059 integral component of presynaptic active zone membrane
GO:1902414 protein localization to cell junction

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013162 CD80-like, immunoglobulin C2-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR033314 Nectin-1FamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR041849 Nectin-1, first immunoglobulin (Ig) domainDomainDomain
IPR041850 Nectin-1, second immunoglobulin (Ig) domainDomainDomain

Diseases

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Disease IDSourceNameDescription
225060 OMIMEctodermal dysplasia, Margarita Island type (EDMI)An autosomal recessive form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is a syndrome characterized by the association of cleft lip/palate, ectodermal dysplasia (sparse short and dry scalp hair, sparse eyebrows and eyelashes), and partial syndactyly of the fingers and/or toes. Two thirds of the patients do not manifest oral cleft but present with abnormal teeth and nails. The disease is caused by variants affecting the gene represented in this entry.
225060 OMIMEctodermal dysplasia, Margarita Island type (EDMI)An autosomal recessive form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is a syndrome characterized by the association of cleft lip/palate, ectodermal dysplasia (sparse short and dry scalp hair, sparse eyebrows and eyelashes), and partial syndactyly of the fingers and/or toes. Two thirds of the patients do not manifest oral cleft but present with abnormal teeth and nails. The disease is caused by variants affecting the gene represented in this entry.