Entity Details

Primary name NTRK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16620
EntryNameNTRK2_HUMAN
FullNameBDNF/NT-3 growth factors receptor
TaxID9606
Evidenceevidence at protein level
Length822
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesNTRK2

GO terms

Show/Hide Table
GOName
GO:0001570 vasculogenesis
GO:0001764 neuron migration
GO:0001934 positive regulation of protein phosphorylation
GO:0002020 protease binding
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005030 neurotrophin receptor activity
GO:0005524 ATP binding
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007275 multicellular organism development
GO:0007612 learning
GO:0007623 circadian rhythm
GO:0007631 feeding behavior
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010976 positive regulation of neuron projection development
GO:0014047 glutamate secretion
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 postsynaptic density
GO:0019227 neuronal action potential propagation
GO:0021954 central nervous system neuron development
GO:0021987 cerebral cortex development
GO:0022011 myelination in peripheral nervous system
GO:0030182 neuron differentiation
GO:0030424 axon
GO:0030425 dendrite
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway
GO:0031901 early endosome membrane
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033674 positive regulation of kinase activity
GO:0042490 mechanoreceptor differentiation
GO:0042803 protein homodimerization activity
GO:0043087 regulation of GTPase activity
GO:0043121 neurotrophin binding
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0043679 axon terminus
GO:0046548 retinal rod cell development
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048403 brain-derived neurotrophic factor binding
GO:0048471 perinuclear region of cytoplasm
GO:0048709 oligodendrocyte differentiation
GO:0048935 peripheral nervous system neuron development
GO:0050772 positive regulation of axonogenesis
GO:0051896 regulation of protein kinase B signaling
GO:0051965 positive regulation of synapse assembly
GO:0060175 brain-derived neurotrophic factor-activated receptor activity
GO:0060291 long-term synaptic potentiation
GO:0071230 cellular response to amino acid stimulus
GO:0099183 trans-synaptic signaling by BDNF, modulating synaptic transmission
GO:0099551 trans-synaptic signaling by neuropeptide, modulating synaptic transmission
GO:1902430 negative regulation of amyloid-beta formation
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
GO:2000811 negative regulation of anoikis

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Early endosome membrane
Endosome membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000372 Leucine-rich repeat N-terminal domainDomainDomain
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020455 Tyrosine-protein kinase, neurotrophic receptor, type 2FamilyFamily
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR020777 Tyrosine-protein kinase, neurotrophic receptorFamilyFamily
IPR031635 Tyrosine-protein kinase receptor NTRK, C2-Ig-like domainDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
613886 OMIMObesity, hyperphagia, and developmental delay (OBHD)A disorder characterized by early-onset obesity, hyperphagia, and severe developmental delay in motor function, speech, and language. The disease is caused by variants affecting the gene represented in this entry.
617830 OMIMDevelopmental and epileptic encephalopathy 58 (DEE58)A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE58 is an autosomal dominant condition characterized by onset of refractory seizures in the first days or months of life. The disease may be caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB00321 AmitriptylineDrugbanksmall molecule
DB11823 EsketamineDrugbanksmall molecule
DB11986 EntrectinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB14723 LarotrectinibDrugbanksmall molecule

Interactions

47 interactions

InteractorPartnerSourcesPublicationsLink
NTRK2_HUMANAP1B1_HUMANBioGRID, IntAct21988832 details
NTRK2_HUMANRPB7_HUMANBioGRID, IntAct21988832 details
NTRK2_HUMANNMNA1_HUMANBioGRID, IntAct21988832 details
NTRK2_HUMANNTRK2_HUMANHPRD, Molecular Connections10533983 22269274 details
NTRK2_HUMANNTF4_HUMANBioGRID, HPRD, IntAct11738045 11855816 25241761 29997244 details
NTRK2_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 31980649 details
NTRK2_HUMANSORT_HUMANbhf-ucl, BioGRID21102451 details
NTRK2_HUMANNTF3_HUMANBioGRID, HPRD8621424 details
NTRK2_HUMANFYN_HUMANBioGRID, HPRD9648856 details
NTRK2_HUMANFRS2_HUMANBioGRID10092678 details
NTRK2_HUMANSHC1_HUMANBioGRID, HPRD10092678 12419535 16034442 26253177 28213521 details
NTRK2_HUMANPLCG1_HUMANBioGRID, HPRD10092678 12074588 12419535 26253177 details
NTRK2_HUMANBDNF_HUMANBioGRID, HPRD11855816 21651720 9312147 details
NTRK2_HUMANSHC3_HUMANBioGRID, HPRD12074588 19166614 9507002 details
NTRK2_HUMANGIPC1_HUMANBioGRID, HPRD11251075 14617818 15304335 details
NTRK2_HUMANP85A_HUMANBioGRID12074588 details
NTRK2_HUMANSH2B1_HUMANBioGRID, HPRD12074588 9856458 details
NTRK2_HUMANNCK2_HUMANBioGRID, HPRD12074588 details
NTRK2_HUMANPTN1_HUMANBioGRID, HPRD12237455 25288805 details
NTRK2_HUMANNFIP1_HUMANBioGRID29911254 details
NTRK2_HUMANERBB4_HUMANBioGRID25052836 details
NTRK2_HUMANERBB2_HUMANBioGRID30898150 details
NTRK2_HUMANNCK1_HUMANHPRD12074588 details
NTRK2_HUMANDOK5_HUMANHPRD16647839 details
NTRK2_HUMANHS90B_HUMANIntAct22939624 details
NTRK2_HUMANGCR_HUMANDIP19126684 details
NTRK2_HUMANDLG4_HUMANDIP23424281 details
NTRK2_HUMANSQSTM_HUMANBioGRID, HPRD12471037 18457658 details
NTRK2_HUMANTRAF6_HUMANBioGRID, HPRD18457658 details
NTRK2_HUMANHS90A_HUMANBioGRID22939624 details
NTRK2_HUMANRANB9_HUMANBioGRID20403074 details
NTRK2_HUMANACK1_HUMANBioGRID23598414 details
NTRK2_HUMANTNR16_HUMANBioGRID, HPRD28821608 9927421 details
NTRK2_HUMANSHC4_HUMANBioGRID28213521 details
NTRK2_HUMANSOCS2_HUMANBioGRID29881947 details
NTRK2_HUMANSYUA_HUMANBioGRID28923922 details
NTRK2_HUMANKCNA3_HUMANBioGRID19166614 details
NTRK2_HUMANGRB10_HUMANBioGRID19166614 details
NTRK2_HUMANNMDZ1_HUMANBioGRID26253177 details
NTRK2_HUMANDYL1_HUMANHPRD11157096 details
NTRK2_HUMANFRS3_HUMANHPRD11432792 details
NTRK2_HUMANKDIS_HUMANHPRD15167895 details
NTRK2_HUMANPTN11_HUMANHPRD10386953 details
NTRK2_HUMANSH2B2_HUMANHPRD9856458 details
NTRK2_HUMANUBB_HUMANHPRD16701206 details
NTRK2_HUMANSHC2_HUMANHPRD12006576 9507002 details
NTRK2_HUMANRGRF1_HUMANHPRD15513915 details