Entity Details

Primary name RGS4
Entity type gene
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Details

PrimaryID5999
RefseqGeneNG_023312
SymbolRGS4
Nameregulator of G protein signaling 4
Chromosome1
Location1q23.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-04-21
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsRGS4_HUMAN

GO terms

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GOName
GO:0000188 obsolete inactivation of MAPK activity
GO:0001965 G-protein alpha-subunit binding
GO:0001975 response to amphetamine
GO:0005096 GTPase activator activity
GO:0005516 calmodulin binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007420 brain development
GO:0008277 regulation of G protein-coupled receptor signaling pathway
GO:0010460 positive regulation of heart rate
GO:0032991 protein-containing complex
GO:0042220 response to cocaine
GO:0043278 response to morphine
GO:0045471 response to ethanol
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway
GO:0051924 regulation of calcium ion transport
GO:0060160 negative regulation of dopamine receptor signaling pathway
GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
GO:0110053 regulation of actin filament organization
GO:1900924 negative regulation of glycine import across plasma membrane
GO:1901380 negative regulation of potassium ion transmembrane transport
GO:1990791 dorsal root ganglion development
GO:2000463 positive regulation of excitatory postsynaptic potential

Diseases

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Disease IDSourceNameDescription
181500 OMIMSchizophrenia (SCZD)A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Disease susceptibility may be associated with variants affecting the gene represented in this entry.