Entity Details

Primary name NKX2-1
Entity type gene
Source Source Link

Details

PrimaryID7080
RefseqGeneNG_013365
SymbolNKX2-1
NameNK2 homeobox 1
Chromosome14
Location14q13.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-24
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsNKX21_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001161 intronic transcription regulatory region sequence-specific DNA binding
GO:0001764 neuron migration
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006644 phospholipid metabolic process
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007492 endoderm development
GO:0007626 locomotory behavior
GO:0008134 transcription factor binding
GO:0009725 response to hormone
GO:0010628 positive regulation of gene expression
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0019899 enzyme binding
GO:0021759 globus pallidus development
GO:0021766 hippocampus development
GO:0021795 cerebral cortex cell migration
GO:0021798 forebrain dorsal/ventral pattern formation
GO:0021877 forebrain neuron fate commitment
GO:0021892 cerebral cortex GABAergic interneuron differentiation
GO:0021983 pituitary gland development
GO:0030154 cell differentiation
GO:0030324 lung development
GO:0030336 negative regulation of cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030878 thyroid gland development
GO:0030900 forebrain development
GO:0031128 developmental induction
GO:0033327 Leydig cell differentiation
GO:0042753 positive regulation of circadian rhythm
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048511 rhythmic process
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048709 oligodendrocyte differentiation
GO:0060430 lung saccule development
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060486 club cell differentiation
GO:0060510 type II pneumocyte differentiation

Diseases

Show/Hide Table
Disease IDSourceNameDescription
610978 OMIMChoreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction (CAHTP)An autosomal dominant disorder that manifests in infancy with neurological disturbances, hypothyroidism, and respiratory problems. It is characterized by movement abnormalities beginning with muscular hypotonia followed by the development of chorea, athetosis, dystonia, ataxia, and dysarthria. The disease is caused by variants affecting the gene represented in this entry.
118700 OMIMChorea, hereditary benign (BHC)A rare autosomal dominant movement disorder, defined by early onset in childhood, a stable or non-progressive course of chorea, and no mental deterioration. Chorea is characterized by involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movement. The disease is caused by variants affecting the gene represented in this entry.
188550 OMIMThyroid cancer, non-medullary, 1 (NMTC1)A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

179 interactions

InteractorPartnerSourcesPublicationsLink
NKX2-1CCDC59UniProt11152647 details
NKX2-1ABL1IntAct17474147 details
NKX2-1CRKIntAct17474147 details
NKX2-1SRCIntAct17474147 details
NKX2-1FYNIntAct17474147 details
NKX2-1GRB2IntAct17474147 details
NKX2-1NCK1IntAct17474147 details
NKX2-1SMAD3IntAct18003659 details
NKX2-1FOXA1BioGRID, IntAct17220277 18003659 28192407 details
NKX2-1RARABioGRID, HPRD10617585 11274148 details
NKX2-1NCOA2BioGRID, HPRD10617585 details
NKX2-1HIPK2BioGRID, HPRD11438542 details
NKX2-1CAVIN1BioGRID9582279 details
NKX2-1NCOA3BioGRID11076796 15449938 details
NKX2-1CREBBPBioGRID, HPRD11076796 11713256 15449938 details
NKX2-1PAX8BioGRID, HPRD12441357 14970209 details
NKX2-1CALRBioGRID, HPRD9988700 details
NKX2-1NCOA1BioGRID, HPRD11076796 11713256 15449938 details
NKX2-1TDGHPRD11438542 details
NKX2-1GATA6HPRD11733512 details
NKX2-1RELABioGRID, HPRD12040027 details
NKX2-1DDB1BioGRID28192407 details
NKX2-1HOXB5BioGRID21677782 details
NKX2-1PARP1BioGRID28192407 details
NKX2-1PCNABioGRID28192407 details
NKX2-1PRKDCBioGRID28192407 details
NKX2-1RPA2BioGRID28192407 details
NKX2-1WRNBioGRID28192407 details
NKX2-1XRCC5BioGRID28192407 details
NKX2-1FOXA2BioGRID17220277 details
NKX2-1MAPK1HPRD10733581 details
NKX2-1WWTR1HPRD14970209 details
NKX2-1PGDBioGRID28192407 details
NKX2-1AMOTL2BioGRID28192407 details
NKX2-1APTXBioGRID28192407 details
NKX2-1ATF2BioGRID28192407 details
NKX2-1ATF7BioGRID28192407 details
NKX2-1ATP5POBioGRID28192407 details
NKX2-1BANF1BioGRID28192407 details
NKX2-1CEBPBBioGRID28192407 details
NKX2-1CGASBioGRID28192407 details
NKX2-1CHD2BioGRID28192407 details
NKX2-1CHD4BioGRID28192407 details
NKX2-1CHD7BioGRID28192407 details
NKX2-1RTRAFBioGRID28192407 details
NKX2-1NUDT21BioGRID28192407 details
NKX2-1CTBP1BioGRID28192407 details
NKX2-1GLUD1BioGRID28192407 details
NKX2-1LIG3BioGRID28192407 details
NKX2-1LIG4BioGRID28192407 details
NKX2-1IRF2BPLBioGRID28192407 details
NKX2-1EMDBioGRID28192407 details
NKX2-1ESYT2BioGRID28192407 details
NKX2-1ETV6BioGRID28192407 details
NKX2-1FOSL1BioGRID28192407 details
NKX2-1FUSBioGRID28192407 details
NKX2-1GAPDHBioGRID28192407 details
NKX2-1H2AZ2BioGRID28192407 details
NKX2-1MACROH2A1BioGRID28192407 details
NKX2-1HDAC1BioGRID28192407 details
NKX2-1HMGA1BioGRID28192407 details
NKX2-1IFI16BioGRID28192407 details
NKX2-1ILF2BioGRID28192407 details
NKX2-1IMPDH2BioGRID28192407 details
NKX2-1JUNBBioGRID28192407 details
NKX2-1KPNB1BioGRID28192407 details
NKX2-1KPNA4BioGRID28192407 details
NKX2-1KRT1BioGRID28192407 details
NKX2-1KRT9BioGRID28192407 details
NKX2-1KRT14BioGRID28192407 details
NKX2-1LMNABioGRID28192407 details
NKX2-1LMNB1BioGRID28192407 details
NKX2-1MCM2BioGRID28192407 details
NKX2-1MCM7BioGRID28192407 details
NKX2-1MECP2BioGRID28192407 details
NKX2-1NFATC2BioGRID28192407 details
NKX2-1NFICBioGRID28192407 details
NKX2-1NONOBioGRID28192407 details
NKX2-1SLC25A3BioGRID28192407 details
NKX2-1NKX2-1BioGRID28192407 details
NKX2-1TMPOBioGRID28192407 details
NKX2-1H4C1BioGRID28192407 details
NKX2-1MTA2BioGRID28192407 details
NKX2-1NUP155BioGRID28192407 details
NKX2-1MDC1BioGRID28192407 details
NKX2-1MVPBioGRID28192407 details
NKX2-1MYL12ABioGRID28192407 details
NKX2-1HNRNPUL1BioGRID28192407 details
NKX2-1KDM1ABioGRID28192407 details
NKX2-1NUP205BioGRID28192407 details
NKX2-1NUP160BioGRID28192407 details
NKX2-1NUP188BioGRID28192407 details
NKX2-1MAFFBioGRID28192407 details
NKX2-1IRF2BP1BioGRID28192407 details
NKX2-1RBMXBioGRID28192407 details
NKX2-1NDC1BioGRID28192407 details
NKX2-1NUP133BioGRID28192407 details
NKX2-1NUP107BioGRID28192407 details
NKX2-1NUP37BioGRID28192407 details
NKX2-1JDP2BioGRID28192407 details
NKX2-1LEMD2BioGRID28192407 details
NKX2-1IRF2BP2BioGRID28192407 details
NKX2-1NUP43BioGRID28192407 details
NKX2-1NUP35BioGRID28192407 details
NKX2-1NUP62BioGRID28192407 details
NKX2-1NUP85BioGRID28192407 details
NKX2-1NUP88BioGRID28192407 details
NKX2-1NUP93BioGRID28192407 details
NKX2-1NUP98BioGRID28192407 details
NKX2-1NUP58BioGRID28192407 details
NKX2-1NXF1BioGRID28192407 details
NKX2-1OVOL2BioGRID28192407 details
NKX2-1SERBP1BioGRID28192407 details
NKX2-1PARP2BioGRID28192407 details
NKX2-1POLDIP3BioGRID28192407 details
NKX2-1CBFBBioGRID28192407 details
NKX2-1PGAM5BioGRID28192407 details
NKX2-1PHBBioGRID28192407 details
NKX2-1PNKPBioGRID28192407 details
NKX2-1NUP210BioGRID28192407 details
NKX2-1PSMC3BioGRID28192407 details
NKX2-1PSME1BioGRID28192407 details
NKX2-1PTBP1BioGRID28192407 details
NKX2-1PUF60BioGRID28192407 details
NKX2-1RAE1BioGRID28192407 details
NKX2-1RANGAP1BioGRID28192407 details
NKX2-1RANBioGRID28192407 details
NKX2-1RBBP4BioGRID28192407 details
NKX2-1RBM14BioGRID28192407 details
NKX2-1TAF15BioGRID28192407 details
NKX2-1RCC1BioGRID28192407 details
NKX2-1RCOR1BioGRID28192407 details
NKX2-1RPA1BioGRID28192407 details
NKX2-1RPA3BioGRID28192407 details
NKX2-1RFC1BioGRID28192407 details
NKX2-1RFC2BioGRID28192407 details
NKX2-1RFC3BioGRID28192407 details
NKX2-1RFC4BioGRID28192407 details
NKX2-1RFC5BioGRID28192407 details
NKX2-1RUNX1BioGRID28192407 details
NKX2-1RUVBL1BioGRID28192407 details
NKX2-1RUVBL2BioGRID28192407 details
NKX2-1SATB2BioGRID28192407 details
NKX2-1SEC13BioGRID28192407 details
NKX2-1SEH1LBioGRID28192407 details
NKX2-1SRSF10BioGRID28192407 details
NKX2-1SFPQBioGRID28192407 details
NKX2-1SMARCA5BioGRID28192407 details
NKX2-1SSBP1BioGRID28192407 details
NKX2-1SSRP1BioGRID28192407 details
NKX2-1TBL1XR1BioGRID28192407 details
NKX2-1TCF20BioGRID28192407 details
NKX2-1CCT2BioGRID28192407 details
NKX2-1CCT6ABioGRID28192407 details
NKX2-1TEAD1BioGRID28192407 details
NKX2-1VCPBioGRID28192407 details
NKX2-1TCF7L2BioGRID28192407 details
NKX2-1TFAMBioGRID28192407 details
NKX2-1TFCP2BioGRID28192407 details
NKX2-1ALYREFBioGRID28192407 details
NKX2-1TRIM28BioGRID28192407 details
NKX2-1TMEM209BioGRID28192407 details
NKX2-1TMEM214BioGRID28192407 details
NKX2-1TOP1BioGRID28192407 details
NKX2-1TOP2ABioGRID28192407 details
NKX2-1THRAP3BioGRID28192407 details
NKX2-1TRA2BBioGRID28192407 details
NKX2-1UBE2IBioGRID28192407 details
NKX2-1VRK3BioGRID28192407 details
NKX2-1CSE1LBioGRID28192407 details
NKX2-1XRCC1BioGRID28192407 details
NKX2-1XRCC4BioGRID28192407 details
NKX2-1XRCC6BioGRID28192407 details
NKX2-1ZFHX3BioGRID28192407 details
NKX2-1ZNF384BioGRID28192407 details
NKX2-1ROR1IntAct22439932 details
NKX2-1SREBF2IntAct23625920 details
NKX2-1TMEM245IntAct23625920 details
NKX2-1CCL15IntAct33179750 details