Entity Details

Primary name TBL1X_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60907
EntryNameTBL1X_HUMAN
FullNameF-box-like/WD repeat-containing protein TBL1X
TaxID9606
Evidenceevidence at protein level
Length577
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesTBL1X

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006508 proteolysis
GO:0007605 sensory perception of sound
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0016575 histone deacetylation
GO:0017053 transcription repressor complex
GO:0019216 regulation of lipid metabolic process
GO:0019904 protein domain specific binding
GO:0030522 intracellular receptor signaling pathway
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050821 protein stabilization
GO:0072686 mitotic spindle
GO:0090263 positive regulation of canonical Wnt signaling pathway

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR006594 LIS1 homology motifDomainDomain
IPR011047 Quinoprotein alcohol dehydrogenase-like superfamilyFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR020472 G-protein beta WD-40 repeatRepeatRepeat
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
301033 OMIMHypothyroidism, congenital, non-goitrous, 8 (CHNG8)A form of central hypothyroidism, a disorder characterized by sub-optimal thyroid hormone secretion, due to insufficient stimulation by the thyroid stimulating hormone of an otherwise normal thyroid gland. It may be caused by congenital or acquired disorders of the pituitary gland or hypothalamus. CHNG8 is a congenital, X-linked, relatively mild form which may be accompanied by hearing loss in some patients. The disease is caused by variants affecting the gene represented in this entry.

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
TBL1X_HUMANHDAC3_HUMANBioGRID, HPRD, IntAct, UniProt10809664 10944117 11931768 16980585 18202150 21258344 23752268 28348241 details
TBL1X_HUMANTBL1R_HUMANBioGRID, HPRD, IntAct15601853 18202150 18374649 21258344 27880911 details
TBL1X_HUMANDLX3_HUMANBioGRID, IntAct21988832 details
TBL1X_HUMANHPT_HUMANBioGRID, IntAct21988832 details
TBL1X_HUMANKHDR1_HUMANBioGRID, IntAct21988832 details
TBL1X_HUMANDNJB4_HUMANBioGRID, IntAct21988832 details
TBL1X_HUMANCTNB1_HUMANBioGRID, HPRD, IntAct11389839 18193033 25241761 details
TBL1X_HUMANFOXK2_HUMANBioGRID, MINT25609649 27773593 details
TBL1X_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
TBL1X_HUMANTINF2_HUMANbhf-ucl, BioGRID21044950 details
TBL1X_HUMANARL3_HUMANBioGRID, IntAct32296183 details
TBL1X_HUMANGPS2_HUMANBioGRID, DIP, HPRD, IntAct11931768 21240272 24943844 26070566 26186194 28514442 details
TBL1X_HUMANTBL1X_HUMANBioGRID, DIP16258276 21240272 details
TBL1X_HUMANDNJB1_HUMANIntAct32814053 details
TBL1X_HUMANKLF11_HUMANIntAct32814053 details
TBL1X_HUMANHAIR_HUMANBioGRID, IntAct20211142 details
TBL1X_HUMANNCOR1_HUMANBioGRID, HPRD10809664 10944117 11931768 12628926 15601853 18202150 22294699 27880911 details
TBL1X_HUMANNCOR2_HUMANBioGRID, HPRD10809664 10944117 12502735 12628926 21240272 details
TBL1X_HUMANH2B2E_HUMANBioGRID, HPRD12628926 15601853 details
TBL1X_HUMANH4_HUMANBioGRID, HPRD12628926 15601853 30804502 details
TBL1X_HUMANH2A2A_HUMANBioGRID12628926 details
TBL1X_HUMANH32_HUMANBioGRID12628926 details
TBL1X_HUMANTAB2_HUMANBioGRID12150997 details
TBL1X_HUMANTHB_HUMANBioGRID10809664 17242407 details
TBL1X_HUMANSKP1_HUMANBioGRID, HPRD11389839 details
TBL1X_HUMANTHA_HUMANBioGRID17242407 details
TBL1X_HUMANUB2R1_HUMANBioGRID14980219 details
TBL1X_HUMANUB2D1_HUMANBioGRID14980219 details
TBL1X_HUMANUBC9_HUMANBioGRID26369384 details
TBL1X_HUMANMECP2_HUMANBioGRID28348241 details
TBL1X_HUMANCYBP_HUMANBioGRID, IntAct11389839 25241761 details
TBL1X_HUMANHDAC5_HUMANBioGRID, IntAct11931768 21081666 23752268 details
TBL1X_HUMANSIAH1_HUMANBioGRID11389839 details
TBL1X_HUMANCTBP1_HUMANBioGRID18374649 details
TBL1X_HUMANSIN3A_HUMANBioGRID17210713 details
TBL1X_HUMANUB2E3_HUMANBioGRID18202150 details
TBL1X_HUMANEMD_HUMANBioGRID17620012 details
TBL1X_HUMANNRDC_HUMANBioGRID22294699 details
TBL1X_HUMANTF65_HUMANBioGRID21189284 details
TBL1X_HUMANUBP44_HUMANBioGRID27880911 32076268 details
TBL1X_HUMANCOR2A_HUMANHPRD12628926 details