Entity Details

Primary name ASNS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08243
EntryNameASNS_HUMAN
FullNameAsparagine synthetase [glutamine-hydrolyzing]
TaxID9606
Evidenceevidence at protein level
Length561
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesASNS

GO terms

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GOName
GO:0001889 liver development
GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006529 asparagine biosynthetic process
GO:0006541 glutamine metabolic process
GO:0009066 aspartate family amino acid metabolic process
GO:0009416 response to light stimulus
GO:0009612 response to mechanical stimulus
GO:0009636 response to toxic substance
GO:0031427 response to methotrexate
GO:0032354 response to follicle-stimulating hormone
GO:0032870 cellular response to hormone stimulus
GO:0042149 cellular response to glucose starvation
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043200 response to amino acid
GO:0045931 positive regulation of mitotic cell cycle
GO:0070981 L-asparagine biosynthetic process

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001962 Asparagine synthaseDomainDomain
IPR006426 Asparagine synthase, glutamine-hydrolyzingFamilyFamily
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR017932 Glutamine amidotransferase type 2 domainDomainDomain
IPR029055 Nucleophile aminohydrolases, N-terminalFamilyHomologous superfamily
IPR033738 Asparagine synthase, N-terminal domainDomainDomain

Diseases

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Disease IDSourceNameDescription
615574 OMIMAsparagine synthetase deficiency (ASNSD)An inborn error of asparagine biosynthesis that results in a severe neurologic disorder characterized by microcephaly, severely delayed psychomotor development, progressive encephalopathy, cortical atrophy, and seizure or hyperekplexic activity. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00128 Aspartic acidDrugbanksmall molecule
DB00130 L-GlutamineDrugbanksmall molecule
DB00142 Glutamic acidDrugbanksmall molecule
DB00171 ATPDrugbanksmall molecule
DB00174 AsparagineDrugbanksmall molecule