Entity Details

Primary name SPYA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21549
EntryNameSPYA_HUMAN
FullNameSerine--pyruvate aminotransferase
TaxID9606
Evidenceevidence at protein level
Length392
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesAGXT

GO terms

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GOName
GO:0004760 serine-pyruvate transaminase activity
GO:0005759 mitochondrial matrix
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0008104 protein localization
GO:0008453 alanine-glyoxylate transaminase activity
GO:0008483 transaminase activity
GO:0009436 glyoxylate catabolic process
GO:0016597 amino acid binding
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate
GO:0019448 L-cysteine catabolic process
GO:0019752 carboxylic acid metabolic process
GO:0030170 pyridoxal phosphate binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042853 L-alanine catabolic process
GO:0042866 pyruvate biosynthetic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043621 protein self-association
GO:0046487 glyoxylate metabolic process
GO:0051384 response to glucocorticoid
GO:0051591 response to cAMP

Subcellular Location

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Subcellular Location
Mitochondrion
Peroxisome

Domains

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DomainNameCategoryType
IPR000192 Aminotransferase class V domainDomainDomain
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015422 Pyridoxal phosphate-dependent transferase, small domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily
IPR020578 Aminotransferase class-V, pyridoxal-phosphate binding siteSiteBinding site
IPR024169 Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminaseFamilyFamily

Diseases

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Disease IDSourceNameDescription
259900 OMIMHyperoxaluria primary 1 (HP1)An inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and progressive tissue accumulation of insoluble calcium oxalate. Affected individuals are at risk for nephrolithiasis, nephrocalcinosis and early onset end-stage renal disease. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00133 SerineDrugbanksmall molecule
DB00145 GlycineDrugbanksmall molecule
DB00160 AlanineDrugbanksmall molecule
DB02079 Aminooxyacetic acidDrugbanksmall molecule
DB04083 N(6)-(pyridoxal phosphate)-L-lysineDrugbanksmall molecule
DB08060 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACIDDrugbanksmall molecule

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
SPYA_HUMANSNCAP_HUMANHPRD, IntAct16169070 details
SPYA_HUMANTHIL_HUMANBioGRID, IntAct21988832 details
SPYA_HUMANKR123_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANATX1L_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANNT2NC_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANFHL5_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANEFS_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANPRDM6_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANFOSB_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANK1C40_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANTPC14_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANBATF3_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANPA2GX_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANMORN5_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANFNTB_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANTTC19_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANSPYA_HUMANBioGRID, DIP, IntAct12899834 22529745 32296183 details
SPYA_HUMANHXA1_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANCS054_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANKRA81_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANCK001_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANSPRY7_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANKRA92_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANLPXN_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANKRT37_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANMDFI_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANRFX6_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANKRA11_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANKRA31_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANCL074_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANF168B_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANCHIC2_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANMS18B_HUMANBioGRID, IntAct32296183 details
SPYA_HUMANPEX5_HUMANBioGRID, DIP, HPRD15911627 20178365 22529745 details
SPYA_HUMANBMI1_HUMANBioGRID19451220 details
SPYA_HUMANGLP1R_HUMANBioGRID28597972 details
SPYA_HUMANPRIC4_HUMANBioGRID32296183 details
SPYA_HUMANNT2NA_HUMANBioGRID32296183 details