Entity Details

Primary name ATM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13315
EntryNameATM_HUMAN
FullNameSerine-protein kinase ATM
TaxID9606
Evidenceevidence at protein level
Length3056
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesATM

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000425 pexophagy
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000729 DNA double-strand break processing
GO:0001541 ovarian follicle development
GO:0001666 response to hypoxia
GO:0001756 somitogenesis
GO:0002331 pre-B cell allelic exclusion
GO:0003677 DNA binding
GO:0004674 protein serine/threonine kinase activity
GO:0004677 DNA-dependent protein kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005782 peroxisomal matrix
GO:0005819 spindle
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007094 mitotic spindle assembly checkpoint signaling
GO:0007131 reciprocal meiotic recombination
GO:0007140 male meiotic nuclear division
GO:0007143 female meiotic nuclear division
GO:0007165 signal transduction
GO:0007420 brain development
GO:0007507 heart development
GO:0008340 determination of adult lifespan
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009791 post-embryonic development
GO:0010212 response to ionizing radiation
GO:0010506 regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016572 histone phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0030335 positive regulation of cell migration
GO:0030889 negative regulation of B cell proliferation
GO:0031410 cytoplasmic vesicle
GO:0032210 regulation of telomere maintenance via telomerase
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0033129 positive regulation of histone phosphorylation
GO:0033151 V(D)J recombination
GO:0035264 multicellular organism growth
GO:0036289 peptidyl-serine autophosphorylation
GO:0042159 lipoprotein catabolic process
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525 positive regulation of neuron apoptotic process
GO:0044877 protein-containing complex binding
GO:0045141 meiotic telomere clustering
GO:0045785 positive regulation of cell adhesion
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046777 protein autophosphorylation
GO:0047485 protein N-terminus binding
GO:0048538 thymus development
GO:0048599 oocyte development
GO:0051402 neuron apoptotic process
GO:0071044 histone mRNA catabolic process
GO:0071300 cellular response to retinoic acid
GO:0071480 cellular response to gamma radiation
GO:0071481 cellular response to X-ray
GO:0071500 cellular response to nitrosative stress
GO:0090399 replicative senescence
GO:0097694 establishment of RNA localization to telomere
GO:0097695 establishment of protein-containing complex localization to telomere
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900034 regulation of cellular response to heat
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1903626 positive regulation of DNA catabolic process
GO:1903978 regulation of microglial cell activation
GO:1904262 negative regulation of TORC1 signaling
GO:1904354 negative regulation of telomere capping
GO:1904358 positive regulation of telomere maintenance via telomere lengthening
GO:1904884 positive regulation of telomerase catalytic core complex assembly
GO:1905843 regulation of cellular response to gamma radiation
GO:1990391 DNA repair complex

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Nucleus

Domains

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DomainNameCategoryType
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR003151 PIK-related kinase, FATDomainDomain
IPR003152 FATC domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014009 PIK-related kinaseDomainDomain
IPR015519 Serine/threonine-protein kinase ATM/Tel1FamilyFamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR021668 Telomere-length maintenance and DNA damage repairDomainDomain
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily
IPR044107 ATM, catalytic domainDomainDomain

Diseases

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Disease IDSourceNameDescription
208900 OMIMAtaxia telangiectasia (AT)A rare recessive disorder characterized by progressive cerebellar ataxia, dilation of the blood vessels in the conjunctiva and eyeballs, immunodeficiency, growth retardation and sexual immaturity. Patients have a strong predisposition to cancer; about 30% of patients develop tumors, particularly lymphomas and leukemias. Cells from affected individuals are highly sensitive to damage by ionizing radiation and resistant to inhibition of DNA synthesis following irradiation. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule

Interactions

169 interactions

InteractorPartnerSourcesPublicationsLink
ATM_HUMANP53_HUMANBioGRID, HPRD, MINT10608806 10673501 10713094 10744722 10864201 11459832 11551930 11709713 11875057 14744854 15064416 15159397 15632067 15713674 15790808 16858402 17157788 17409407 19965871 20010693 21383020 23907539 24469230 25086746 27559048 30252118 9765199 9843217 details
ATM_HUMANMDC1_HUMANBioGRID, HPRD, UniProt12607005 14519663 18006705 26734725 28943310 29656893 details
ATM_HUMANH2AX_HUMANBioGRID, DIP, HPRD, MINT11571274 11893489 16858402 18344987 21676867 21704408 22184063 22451927 26095369 27918549 32518374 9488723 details
ATM_HUMANABL1_HUMANBioGRID, DIP, HPRD, IntAct10212258 11375976 17409407 20798688 9168116 9168117 details
ATM_HUMANTERF1_HUMANBioGRID, DIP, HPRD, IntAct11375976 15314656 18160036 details
ATM_HUMANAATF_HUMANHPRD, IntAct17157788 details
ATM_HUMANPP1A_HUMANBioGRID, IntAct17274640 details
ATM_HUMANPP1G_HUMANBioGRID, IntAct17274640 details
ATM_HUMANTELO2_HUMANBioGRID, IntAct, UniProt18160036 20427287 20801936 details
ATM_HUMANSMC1A_HUMANBioGRID, HPRD, UniProt11877376 11877377 details
ATM_HUMANSOSB1_HUMANUniProt18449195 details
ATM_HUMANNEMO_HUMANBioGRID, MINT16497931 18583959 24457965 28202068 30254148 32731169 details
ATM_HUMANATM_HUMANBioGRID, HPRD, IntAct10608806 12556884 14519663 15790808 16858402 16906133 18571408 20360068 details
ATM_HUMANTP53B_HUMANBioGRID, HPRD, IntAct, UniProt11042216 12447390 12697768 18996087 20010693 22621922 29656893 details
ATM_HUMAN2A5G_HUMANBioGRID, I2D21460856 details
ATM_HUMANACL6B_HUMANBioGRID, MINT25640309 details
ATM_HUMANMAP1S_HUMANBioGRID, MINT25640309 details
ATM_HUMANNREP_HUMANBioGRID, MINT25640309 details
ATM_HUMANHEMH_HUMANBioGRID, MINT25640309 details
ATM_HUMANHSP7C_HUMANBioGRID, MINT25640309 details
ATM_HUMANZN821_HUMANBioGRID, MINT25640309 details
ATM_HUMANNU4M_HUMANBioGRID, MINT25640309 details
ATM_HUMANNR4A1_HUMANBioGRID, MINT25640309 details
ATM_HUMANNSD3_HUMANBioGRID, MINT25640309 details
ATM_HUMANBCAS3_HUMANBioGRID, MINT25640309 details
ATM_HUMANERRFI_HUMANBioGRID, MINT25640309 details
ATM_HUMANMTA3_HUMANBioGRID, MINT25640309 details
ATM_HUMANIL24_HUMANBioGRID, MINT25640309 details
ATM_HUMANARY2_HUMANBioGRID, MINT25640309 details
ATM_HUMANOSGI1_HUMANBioGRID, MINT25640309 details
ATM_HUMANTFF1_HUMANBioGRID, MINT25640309 details
ATM_HUMANERR3_HUMANBioGRID, IntAct32296183 details
ATM_HUMANTERF2_HUMANBioGRID, DIP15314656 details
ATM_HUMANRIR2B_HUMANBioGRID, DIP19015526 details
ATM_HUMANFBX31_HUMANDIP19412162 details
ATM_HUMANNOTC1_HUMANDIP25895060 details
ATM_HUMANNBN_HUMANBioGRID, DIP, HPRD10608806 10783165 10839544 10839545 11252893 15758953 17507690 22464731 24800743 25088203 25895060 30952868 details
ATM_HUMANPEX5_HUMANBioGRID, DIP, HPRD10567403 26344566 details
ATM_HUMANBRCA1_HUMANBioGRID, HPRD, UniProt10550055 10608806 10783165 10866324 11114888 15713674 17478428 18344987 29656893 details
ATM_HUMANNF2L2_HUMANIntAct32911434 details
ATM_HUMANCTIP_HUMANBioGRID, HPRD10608806 10910365 11689934 22544744 23468639 details
ATM_HUMANFACD2_HUMANBioGRID, HPRD12086603 14499622 details
ATM_HUMANBLM_HUMANBioGRID10783165 12034743 29523790 details
ATM_HUMANAP1B1_HUMANBioGRID, HPRD10608806 9707615 details
ATM_HUMANATR_HUMANBioGRID10608806 17124492 details
ATM_HUMANPRKDC_HUMANBioGRID, HPRD10464290 10608806 details
ATM_HUMANCHK1_HUMANBioGRID, HPRD10608806 11252893 11390642 12676583 details
ATM_HUMANE4F1_HUMANBioGRID10608806 details
ATM_HUMAN4EBP1_HUMANBioGRID, HPRD10608806 10713094 11146653 12588975 9806882 details
ATM_HUMANDNLI4_HUMANBioGRID10608806 details
ATM_HUMANMRE11_HUMANBioGRID, HPRD10608806 10783165 15758953 details
ATM_HUMANRAD17_HUMANBioGRID, HPRD10608806 11418864 18344987 details
ATM_HUMANWRN_HUMANBioGRID, HPRD10608806 10839545 11252893 details
ATM_HUMANBRCA2_HUMANBioGRID15199141 details
ATM_HUMANMCM2_HUMANBioGRID15210935 details
ATM_HUMANRHEB_HUMANBioGRID, HPRD15854902 details
ATM_HUMANCDC6_HUMANBioGRID20048340 details
ATM_HUMANCXXC5_HUMANBioGRID19557330 details
ATM_HUMANMCPH1_HUMANBioGRID16872911 25301947 details
ATM_HUMANDDX1_HUMANBioGRID18710941 details
ATM_HUMANKAT8_HUMANBioGRID15923642 details
ATM_HUMANATF2_HUMANBioGRID15916964 18397884 details
ATM_HUMANFOXO3_HUMANBioGRID18344987 details
ATM_HUMANHDAC1_HUMANBioGRID10531300 details
ATM_HUMANCHK2_HUMANBioGRID, HPRD10713094 10744722 10973490 11901158 12024051 12242661 12493754 15064416 15790808 16794575 20010693 details
ATM_HUMANPARP1_HUMANBioGRID17428792 details
ATM_HUMANCHD4_HUMANBioGRID21219611 details
ATM_HUMANEXO1_HUMANBioGRID20019063 details
ATM_HUMANE2F1_HUMANBioGRID, HPRD11459832 details
ATM_HUMANDYRK2_HUMANBioGRID19965871 details
ATM_HUMANTRAF6_HUMANBioGRID20932475 details
ATM_HUMANTCL1A_HUMANBioGRID22065599 details
ATM_HUMANXRCC5_HUMANBioGRID, HPRD15758953 17171639 details
ATM_HUMANATRIP_HUMANBioGRID, HPRD15758953 details
ATM_HUMANBRE1A_HUMANBioGRID21362549 details
ATM_HUMANBRE1B_HUMANBioGRID21362549 details
ATM_HUMANEIF3E_HUMANBioGRID22508697 details
ATM_HUMANDCAF1_HUMANBioGRID22184063 details
ATM_HUMANDCR1C_HUMANBioGRID, HPRD15456891 details
ATM_HUMANTOPB1_HUMANBioGRID, HPRD11756551 19023333 details
ATM_HUMANMDM2_HUMANBioGRID, HPRD11331603 22976441 27462439 30252118 details
ATM_HUMANKC1D_HUMANBioGRID22976441 details
ATM_HUMANSOCS1_HUMANBioGRID20005840 29991678 details
ATM_HUMANTOP1_HUMANBioGRID12549820 details
ATM_HUMANXPA_HUMANBioGRID, HPRD16540648 details
ATM_HUMANCDN2C_HUMANBioGRID15680327 details
ATM_HUMANDAXX_HUMANBioGRID23405218 details
ATM_HUMANSPSB1_HUMANBioGRID18449195 details
ATM_HUMANRFA1_HUMANBioGRID10713094 details
ATM_HUMANRFA2_HUMANBioGRID10713094 details
ATM_HUMANBCL10_HUMANBioGRID24732096 details
ATM_HUMANRPB1_HUMANBioGRID24957606 9168116 details
ATM_HUMANHIF1A_HUMANBioGRID21095582 details
ATM_HUMANCREB1_HUMANBioGRID, HPRD15073328 16293623 details
ATM_HUMANZEB1_HUMANBioGRID25086746 details
ATM_HUMANRASF1_HUMANBioGRID10608806 details
ATM_HUMANAP3B1_HUMANBioGRID10608806 details
ATM_HUMANBANP_HUMANBioGRID25299772 details
ATM_HUMANRANB9_HUMANBioGRID26943034 details
ATM_HUMANUCHL3_HUMANBioGRID27941124 details
ATM_HUMANCSN5_HUMANBioGRID24710276 details
ATM_HUMANCRX_HUMANBioGRID27107012 details
ATM_HUMANPTC1_HUMANBioGRID15142440 details
ATM_HUMANTRI29_HUMANBioGRID26095369 details
ATM_HUMANPAN2_HUMANBioGRID33097710 details
ATM_HUMANAP2B1_HUMANHPRD9707615 details
ATM_HUMANAP3B2_HUMANHPRD9707615 details
ATM_HUMANVHL_HUMANBioGRID, IntAct16678111 17353931 details
ATM_HUMANATMIN_HUMANBioGRID, MINT17525732 25092319 details
ATM_HUMANRNF8_HUMANIntAct18001825 details
ATM_HUMANTYDP1_HUMANBioGRID, MINT17478428 19851285 details
ATM_HUMANTTI1_HUMANBioGRID, UniProt20427287 20810650 details
ATM_HUMANBRAT1_HUMANBioGRID, IntAct16452482 details
ATM_HUMANMLH1_HUMANBioGRID10783165 details
ATM_HUMANMSH2_HUMANBioGRID10783165 details
ATM_HUMANMSH6_HUMANBioGRID10783165 details
ATM_HUMANRAD50_HUMANBioGRID10783165 details
ATM_HUMANRAD51_HUMANBioGRID, HPRD10212258 details
ATM_HUMANRFC1_HUMANBioGRID10783165 details
ATM_HUMANXPC_HUMANBioGRID19805520 23422745 details
ATM_HUMANSNF5_HUMANBioGRID19805520 details
ATM_HUMANHUWE1_HUMANBioGRID17478428 22213803 details
ATM_HUMANUBP34_HUMANBioGRID17478428 details
ATM_HUMANMED1_HUMANBioGRID17478428 details
ATM_HUMANFANCI_HUMANBioGRID17478428 details
ATM_HUMANSMC3_HUMANBioGRID17478428 details
ATM_HUMANTAOK3_HUMANBioGRID17478428 details
ATM_HUMANDCR1A_HUMANBioGRID18848520 details
ATM_HUMANHNRL1_HUMANBioGRID18480432 details
ATM_HUMANBMI1_HUMANBioGRID20668194 21676867 details
ATM_HUMANSRBP1_HUMANBioGRID20534441 details
ATM_HUMANKAT5_HUMANBioGRID, HPRD16141325 19783983 21704408 details
ATM_HUMANSKP2_HUMANBioGRID22464731 details
ATM_HUMANM3K7_HUMANBioGRID21606198 32731169 details
ATM_HUMANPTPA_HUMANBioGRID16452482 details
ATM_HUMANSMAD7_HUMANBioGRID17172861 details
ATM_HUMANMK14_HUMANBioGRID17172861 details
ATM_HUMANHLAA_HUMANBioGRID20064447 details
ATM_HUMANSPOP_HUMANBioGRID24451148 details
ATM_HUMANTIF1B_HUMANBioGRID23096706 28249048 details
ATM_HUMANMAGC2_HUMANBioGRID23096706 details
ATM_HUMANTF65_HUMANBioGRID24957606 details
ATM_HUMANCDK9_HUMANBioGRID24957606 details
ATM_HUMANWWOX_HUMANBioGRID25331887 26675548 details
ATM_HUMANKDM2A_HUMANBioGRID25823024 details
ATM_HUMANSNAI1_HUMANBioGRID28067227 details
ATM_HUMANFOXO1_HUMANBioGRID27559048 details
ATM_HUMANNOP53_HUMANBioGRID27829214 details
ATM_HUMANRL5_HUMANBioGRID30252118 details
ATM_HUMANRL11_HUMANBioGRID30252118 details
ATM_HUMANAVEN_HUMANBioGRID18571408 details
ATM_HUMANTRI37_HUMANBioGRID30254148 details
ATM_HUMANSTK11_HUMANBioGRID, HPRD11853558 12234250 15713674 details
ATM_HUMANSIM2_HUMANBioGRID30531838 details
ATM_HUMANRSF1_HUMANBioGRID24800743 details
ATM_HUMANSMCA5_HUMANBioGRID24800743 details
ATM_HUMANBAZ1A_HUMANBioGRID24800743 details
ATM_HUMANBAZ1B_HUMANBioGRID24800743 details
ATM_HUMANPELI1_HUMANBioGRID30952868 details
ATM_HUMANCBL_HUMANBioGRID31315051 details
ATM_HUMANUBP28_HUMANBioGRID31938050 details
ATM_HUMANTOP2B_HUMANBioGRID32015321 details
ATM_HUMANPRKN_HUMANBioGRID32029507 details
ATM_HUMANIKKB_HUMANBioGRID32731169 details
ATM_HUMANIKKA_HUMANBioGRID32731169 details
ATM_HUMANRAD9A_HUMANHPRD11278446 12709442 details
ATM_HUMANPARPT_HUMANHPRD11238919 details
ATM_HUMANMCA3_HUMANHPRD15680327 details
ATM_HUMANMDM4_HUMANHPRD15788536 16163388 details