Entity Details

Primary name HLA-C
Entity type gene
Source Source Link

Details

PrimaryID3107
RefseqGeneNG_029422
SymbolHLA-C
Namemajor histocompatibility complex, class I, C
Chromosome6
Location6p21.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1992-10-07
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsHLAC_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0002250 adaptive immune response
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016032 viral process
GO:0030667 secretory granule membrane
GO:0030670 phagocytic vesicle membrane
GO:0031901 early endosome membrane
GO:0042605 peptide antigen binding
GO:0042612 MHC class I protein complex
GO:0043312 neutrophil degranulation
GO:0046977 TAP binding
GO:0050776 regulation of immune response
GO:0055038 recycling endosome membrane
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0070062 extracellular exosome
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane

Diseases

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Disease IDSourceNameDescription
177900 OMIMPsoriasis 1 (PSORS1)A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Disease susceptibility is associated with variants affecting the gene represented in this entry. Allele C*06:02 presents a melanocyte autoantigen ADAMTSL5 (VRSRRCLRL) to Valpha3S1/Vbeta13S1 TCR on CD8-positive T cells, and may trigger an autoimmune response against melanocytes.

Interactions

200 interactions

InteractorPartnerSourcesPublicationsLink
HLA-CB2MBioGRID, HPRD, IntAct, MINT10429675 2450918 26186194 27649529 28514442 28546555 details
HLA-CCDC25ABioGRID, IntAct21988832 details
HLA-CYBX1BioGRID, IntAct21988832 details
HLA-CTANKBioGRID, IntAct21988832 details
HLA-CPRRG4BioGRID, IntAct21988832 details
HLA-CBATF2BioGRID, IntAct21988832 details
HLA-CKIR2DS4HPRD, IntAct19858347 9521070 details
HLA-CKIR2DL1BioGRID, HPRD, IntAct10429675 10820396 11009104 11163076 11323700 12454284 12794140 18624290 19858347 28546555 9378975 9686591 9768753 details
HLA-CKIR2DL3BioGRID, HPRD, IntAct10497191 18322206 19858347 8692965 9768753 details
HLA-CKIR2DL2BioGRID, HPRD, IntAct10190900 10850706 18322206 details
HLA-CKIR2DS1HPRD, IntAct18624290 28546555 7650491 9464792 details
HLA-CKIR2DS5IntAct28685972 details
HLA-CGPR182BioGRID, MINT28298427 details
HLA-CGPR37BioGRID, MINT28298427 details
HLA-CNPSR1BioGRID, MINT28298427 details
HLA-COPRL1BioGRID, MINT28298427 details
HLA-CNLRP12I2D32226298 details
HLA-CLILRB1BioGRID, HPRD12853576 details
HLA-CHLA-CBioGRID12794140 details
HLA-CCD8ABioGRID, HPRD10809759 12899833 details
HLA-CKIR2DS2BioGRID, HPRD11172020 details
HLA-CMAPK8IP2BioGRID25814554 details
HLA-CPSMA6IntAct17353931 details
HLA-CMSNIntAct17353931 details
HLA-CACAT1IntAct17353931 details
HLA-CSELENOFIntAct17353931 details
HLA-CRHPN2IntAct17353931 details
HLA-CMCM3IntAct17353931 details
HLA-CGSTM3IntAct17353931 details
HLA-CPSME3IntAct17353931 details
HLA-CSARS1IntAct17353931 details
HLA-CLTA4HIntAct17353931 details
HLA-CNUDCIntAct17353931 details
HLA-CHLA-ABioGRID, IntAct17353931 26186194 28514442 details
HLA-CPIN1IntAct17353931 details
HLA-CRNF213IntAct17353931 details
HLA-CPRMT1IntAct17353931 details
HLA-CPSMD6IntAct17353931 details
HLA-CUGGT1IntAct17353931 details
HLA-CTUFMIntAct17353931 details
HLA-CPCBP1IntAct17353931 details
HLA-CEIF3FIntAct17353931 details
HLA-CCBR1IntAct17353931 details
HLA-CMAPRE1IntAct17353931 details
HLA-CPCNAIntAct17353931 details
HLA-CPSMB4IntAct17353931 details
HLA-CTRIM28IntAct17353931 details
HLA-CCTPS1IntAct17353931 details
HLA-CGANABIntAct17353931 details
HLA-CNUDT21IntAct17353931 details
HLA-CGOT2IntAct17353931 details
HLA-CGMPSIntAct17353931 details
HLA-CHLA-BBioGRID, IntAct17353931 26186194 28514442 details
HLA-CPSMA2IntAct17353931 details
HLA-CEIF3LIntAct17353931 details
HLA-CCLTCIntAct17353931 details
HLA-CCALM1IntAct17353931 details
HLA-CCALM2IntAct17353931 details
HLA-CCALM3IntAct17353931 details
HLA-CIMPDH2IntAct17353931 details
HLA-CKIR3DS1IntAct27649529 details
HLA-CMAD2L2BioGRID, IntAct, UniProt26186194 28514442 29656893 30022168 details
HLA-CDISC1IntAct31413325 details
HLA-CHSPA5BioGRID, HPRD7957306 details
HLA-CTAP2BioGRID, HPRD9551969 details
HLA-CRNF139BioGRID19720873 details
HLA-CST7BioGRID29395067 details
HLA-CCALRHPRD8769474 details
HLA-CTAPBPHPRD8769474 details
HLA-CSLC38A1IntAct25561175 details
HLA-CTMEM63BBioGRID, IntAct26496610 details
HLA-CKPNA2IntAct24018270 details
HLA-CTSHBBioGRID, IntAct28514442 details
HLA-CTMED6BioGRID, IntAct28514442 details
HLA-CASIC4BioGRID, IntAct28514442 details
HLA-CTMEM30ABioGRID, IntAct26186194 28514442 details
HLA-CST8SIA4BioGRID, IntAct28514442 details
HLA-CTMEM223BioGRID, IntAct26186194 28514442 details
HLA-CLIPGBioGRID, IntAct28514442 details
HLA-CPTCH1BioGRID, IntAct26186194 28514442 details
HLA-CGABRA3BioGRID, IntAct28514442 details
HLA-CHTR3ABioGRID, IntAct28514442 details
HLA-CATP1B3BioGRID, IntAct26186194 28514442 details
HLA-CADAM33BioGRID, IntAct28514442 details
HLA-CHLA-GBioGRID, IntAct26186194 28514442 details
HLA-CNUS1BioGRID, IntAct28514442 details
HLA-CGPR50BioGRID, IntAct26186194 28514442 details
HLA-CUFSP2BioGRID, IntAct26186194 28514442 details
HLA-CCNNM1BioGRID, IntAct26186194 28514442 details
HLA-CPRXL2ABioGRID, IntAct26186194 28514442 details
HLA-CTCTN2BioGRID, IntAct26186194 28514442 details
HLA-CFAM3CBioGRID, IntAct26186194 28514442 details
HLA-CSCARB1BioGRID, IntAct26186194 28514442 details
HLA-CNETO2BioGRID, IntAct26186194 28514442 details
HLA-CCISD2BioGRID, IntAct26186194 28514442 details
HLA-CNEK4BioGRID, IntAct26186194 28514442 details
HLA-CHLA-FBioGRID, IntAct26186194 28514442 details
HLA-CITGA6BioGRID, IntAct26186194 28514442 details
HLA-CHLA-EBioGRID, IntAct26186194 28514442 details
HLA-CDNAJC1BioGRID, IntAct26186194 28514442 details
HLA-CST6GAL1BioGRID, IntAct28514442 details
HLA-CHMOX1BioGRID, IntAct26186194 28514442 details
HLA-CLAMP1BioGRID, IntAct29568061 34079125 details
HLA-CCANXBioGRID, IntAct29568061 details
HLA-CECH1IntAct29426014 details
HLA-CSH2D3CBioGRID, IntAct31980649 details
HLA-CPRKAR1ABioGRID, IntAct31980649 details
HLA-CPXNBioGRID, IntAct31980649 details
HLA-CSHOC2BioGRID, IntAct31980649 details
HLA-CPAK1BioGRID, IntAct31980649 details
HLA-CDOCK3BioGRID, IntAct32203420 details
HLA-CCNR2MINT31616248 details
HLA-CUBCBioGRID16196087 details
HLA-CPCK1BioGRID21726808 details
HLA-CFBXO6BioGRID22268729 details
HLA-CMMS19BioGRID22678362 details
HLA-CADRB2BioGRID23798571 details
HLA-CCUL7BioGRID24711643 details
HLA-CCCDC8BioGRID24711643 details
HLA-CATP1A3BioGRID26186194 details
HLA-CPI4KABioGRID26186194 details
HLA-CSCAPBioGRID26186194 details
HLA-CEIF2AK3BioGRID26186194 details
HLA-CARV1BioGRID26186194 details
HLA-CNSDHLBioGRID26186194 details
HLA-CDNAJC16BioGRID26186194 details
HLA-CPOMGNT1BioGRID26186194 details
HLA-CMR1BioGRID26186194 details
HLA-CITFG1BioGRID26186194 details
HLA-CPACC1BioGRID26186194 details
HLA-CLRFN3BioGRID26186194 details
HLA-CIFI16BioGRID25693804 details
HLA-CFAF2BioGRID26389662 details
HLA-CCDH1BioGRID25468996 details
HLA-CMTM1BioGRID25659891 27880917 details
HLA-CPPM1EBioGRID27880917 details
HLA-CMTMR12BioGRID27432908 details
HLA-CPTPROBioGRID27432908 details
HLA-CEGLN3BioGRID26972000 details
HLA-CMAPK6BioGRID26972000 details
HLA-CRNF4BioGRID29180619 details
HLA-CESR2BioGRID29509190 details
HLA-CHRASBioGRID30639242 details
HLA-CKRASBioGRID30639242 34079125 details
HLA-CVIRMABioGRID29507755 details
HLA-CPHBBioGRID27025967 details
HLA-CCA9BioGRID28692057 details
HLA-CBIRC3BioGRID30948266 details
HLA-CLMBR1LBioGRID31073040 details
HLA-COTULINLBioGRID31056421 details
HLA-CPLEKHA4BioGRID31091453 details
HLA-CEMC1BioGRID27342126 details
HLA-CEMC2BioGRID27342126 details
HLA-CMMGT1BioGRID27342126 details
HLA-CCITBioGRID31586073 details
HLA-CANLNBioGRID31586073 details
HLA-CAURKBBioGRID31586073 details
HLA-CECT2BioGRID31586073 details
HLA-CKIF14BioGRID31586073 details
HLA-CKIF23BioGRID31586073 details
HLA-CNPC1BioGRID33144569 details
HLA-CFAM20CBioGRID32149426 details
HLA-CDNAJB12BioGRID33957083 details
HLA-CDNAJB8BioGRID33957083 details
HLA-CDNAJC11BioGRID33957083 details
HLA-CDNAJC12BioGRID33957083 details
HLA-CDNAJC25BioGRID33957083 details
HLA-CATP2A1BioGRID34079125 details
HLA-CB3GAT1BioGRID34079125 details
HLA-CBCAP31BioGRID34079125 details
HLA-CCALR3BioGRID34079125 details
HLA-CCAV1BioGRID34079125 details
HLA-CCKAP4BioGRID34079125 details
HLA-CDERL1BioGRID34079125 details
HLA-CDHFR2BioGRID34079125 details
HLA-CEBAG9BioGRID34079125 details
HLA-CELOVL5BioGRID34079125 details
HLA-CERGIC1BioGRID34079125 details
HLA-CGJD3BioGRID34079125 details
HLA-CHSD17B11BioGRID34079125 details
HLA-CHSD3B7BioGRID34079125 details
HLA-CLNPKBioGRID34079125 details
HLA-CLRRC59BioGRID34079125 details
HLA-CMARCKSBioGRID34079125 details
HLA-CMETTL7ABioGRID34079125 details
HLA-CPDIA4BioGRID34079125 details
HLA-CPXMP2BioGRID34079125 details
HLA-CRAB3BBioGRID34079125 details
HLA-CRAB5CBioGRID34079125 details
HLA-CRHOBBioGRID34079125 details
HLA-CRPN1BioGRID34079125 details
HLA-CRPN2BioGRID34079125 details
HLA-CSEC61BBioGRID34079125 details
HLA-CSEC62BioGRID34079125 details
HLA-CSSR1BioGRID34079125 details
HLA-CSTX4BioGRID34079125 details
HLA-CSTX7BioGRID34079125 details
HLA-CSYNE3BioGRID34079125 details
HLA-CTRIM37BioGRID33194618 details
HLA-CDDX58BioGRID32513696 details