Entity Details

Primary name ECM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16610
EntryNameECM1_HUMAN
FullNameExtracellular matrix protein 1
TaxID9606
Evidenceevidence at protein level
Length540
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesECM1

GO terms

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GOName
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002020 protease binding
GO:0002063 chondrocyte development
GO:0002576 platelet degranulation
GO:0002828 regulation of type 2 immune response
GO:0003416 endochondral bone growth
GO:0005134 interleukin-2 receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0008022 protein C-terminus binding
GO:0010466 negative regulation of peptidase activity
GO:0019899 enzyme binding
GO:0030500 regulation of bone mineralization
GO:0030502 negative regulation of bone mineralization
GO:0031012 extracellular matrix
GO:0031089 platelet dense granule lumen
GO:0031214 biomineral tissue development
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043236 laminin binding
GO:0045766 positive regulation of angiogenesis
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:2000404 regulation of T cell migration

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR008605 Extracellular matrix protein 1FamilyFamily
IPR020858 Serum albumin-likeFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
247100 OMIMLipoid proteinosis (LiP)Rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane. The disease is caused by variants affecting the gene represented in this entry.

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
ECM1_HUMANATN1_HUMANBioGRID, HPRD, IntAct16713569 details
ECM1_HUMANRERE_HUMANBioGRID, HPRD, IntAct16713569 details
ECM1_HUMANBNI3L_HUMANBioGRID, IntAct21988832 details
ECM1_HUMANIRAK3_HUMANBioGRID, IntAct21988832 details
ECM1_HUMANCPTP_HUMANBioGRID, IntAct21988832 details
ECM1_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
ECM1_HUMANUBQL2_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANSPF27_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANHXC8_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANFKBP6_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANCA109_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANSAM11_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANKLH38_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANLMO4_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANITB4_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANDTX2_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANLCE2A_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANGRN_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANUBQL1_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANMKRN3_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANENKD1_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANKAP3_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANKRA93_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANFRS3_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANTNFL6_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANGCM2_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANLIN7A_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANA1CF_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANRU1C_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANGLCNE_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANGPAN1_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANACTN3_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANSGTB_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANKRA53_HUMANBioGRID, IntAct32296183 details
ECM1_HUMANDDIAS_HUMANBioGRID28079882 details
ECM1_HUMANFBLN1_HUMANHPRD15990087 details
ECM1_HUMANPGBM_HUMANHPRD12604605 details
ECM1_HUMANFXR1_HUMANMINT21653829 details
ECM1_HUMANIL2RB_HUMANBioGRID21217760 details