Entity Details

Primary name LRC8E_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6NSJ5
EntryNameLRC8E_HUMAN
FullNameVolume-regulated anion channel subunit LRRC8E
TaxID9606
Evidenceevidence at protein level
Length796
SequenceStatuscomplete
DateCreated2006-02-07
DateModified2021-06-02

Ontological Relatives

GenesLRRC8E

GO terms

Show/Hide Table
GOName
GO:0005225 volume-sensitive anion channel activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006884 cell volume homeostasis
GO:0015810 aspartate transmembrane transport
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0034702 ion channel complex
GO:0055085 transmembrane transport
GO:0071470 cellular response to osmotic stress
GO:0098656 anion transmembrane transport
GO:0140361 cyclic-GMP-AMP transmembrane import across plasma membrane
GO:1905103 integral component of lysosomal membrane

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Endoplasmic reticulum membrane
Lysosome membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR021040 LRRC8, pannexin-like TM regionDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table