Entity Details

Primary name TCAM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IUC6
EntryNameTCAM1_HUMAN
FullNameTIR domain-containing adapter molecule 1
TaxID9606
Evidenceevidence at protein level
Length712
SequenceStatuscomplete
DateCreated2008-02-05
DateModified2021-06-02

Ontological Relatives

GenesTICAM1

GO terms

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GOName
GO:0002281 macrophage activation involved in immune response
GO:0002735 positive regulation of myeloid dendritic cell cytokine production
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0005739 mitochondrion
GO:0005776 autophagosome
GO:0005829 cytosol
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0010008 endosome membrane
GO:0010508 positive regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0016032 viral process
GO:0019901 protein kinase binding
GO:0030890 positive regulation of B cell proliferation
GO:0031398 positive regulation of protein ubiquitination
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032092 positive regulation of protein binding
GO:0032722 positive regulation of chemokine production
GO:0032728 positive regulation of interferon-beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032816 positive regulation of natural killer cell activation
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043254 regulation of protein-containing complex assembly
GO:0043330 response to exogenous dsRNA
GO:0045087 innate immune response
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0070266 necroptotic process
GO:0071222 cellular response to lipopolysaccharide
GO:0097190 apoptotic signaling pathway
GO:0097342 ripoptosome
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
GO:1900017 positive regulation of cytokine production involved in inflammatory response

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Mitochondrion

Domains

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DomainNameCategoryType
IPR017278 TIR domain-containing adapter molecule 1FamilyFamily
IPR025735 RHIM domainDomainDomain
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily
IPR040886 TRIF, N-terminalDomainDomain

Diseases

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Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
TCAM1_HUMANTCAM2_HUMANBioGRID, HPRD, IntAct12721283 14519765 25736436 31511519 details
TCAM1_HUMANSRSF4_HUMANBioGRID, IntAct21988832 details
TCAM1_HUMANSARM1_HUMANIntAct26592460 details
TCAM1_HUMANTRAF2_HUMANBioGRID14982987 19795416 20047764 details
TCAM1_HUMANTRAF6_HUMANBioGRID, HPRD14530355 14982987 15474016 19795416 20047764 24812060 25736436 details
TCAM1_HUMANUBQL1_HUMANBioGRID21695056 details
TCAM1_HUMANTRAF1_HUMANBioGRID, HPRD14982987 16323247 19795416 details
TCAM1_HUMANTLR3_HUMANBioGRID, HPRD12539043 14982987 25736436 27810922 31511519 details
TCAM1_HUMANIRF3_HUMANBioGRID, HPRD14739303 25636800 details
TCAM1_HUMANTRIM8_HUMANBioGRID28747347 details
TCAM1_HUMANIRF7_HUMANHPRD14739303 details
TCAM1_HUMANTNAP3_HUMANBioGRID, HPRD, MINT15474016 details
TCAM1_HUMANPIAS4_HUMANBioGRID, HPRD, MINT15251447 details
TCAM1_HUMANTBK1_HUMANBioGRID, DIP, HPRD, IntAct, UniProt14530355 15841462 19416887 19656901 21903422 25736436 28049150 28747347 31511519 details
TCAM1_HUMANTRI56_HUMANBioGRID, IntAct22948160 details
TCAM1_HUMANRIPK1_HUMANBioGRID, HPRD15064760 19734906 25736436 33052227 details
TCAM1_HUMANRIPK3_HUMANBioGRID, HPRD15064760 details
TCAM1_HUMANRN216_HUMANBioGRID16968706 details
TCAM1_HUMANTLR4_HUMANBioGRID19656901 25736436 31511519 details
TCAM1_HUMANCBLB_HUMANBioGRID20639876 details
TCAM1_HUMANTRAF3_HUMANBioGRID, HPRD14982987 16306936 16306937 17991829 24577058 28747347 31511519 details
TCAM1_HUMANTRAF5_HUMANBioGRID14982987 details
TCAM1_HUMANTRAF4_HUMANBioGRID, HPRD16052631 details
TCAM1_HUMANMAVS_HUMANBioGRID, HPRD16153868 details
TCAM1_HUMANTRI38_HUMANBioGRID23056470 details
TCAM1_HUMANKSYK_HUMANBioGRID23962979 details
TCAM1_HUMANTCAM1_HUMANBioGRID24577058 details
TCAM1_HUMANCASP8_HUMANBioGRID21737330 33052227 details
TCAM1_HUMANCFLAR_HUMANBioGRID21737330 details
TCAM1_HUMANFOSL1_HUMANBioGRID28049150 details
TCAM1_HUMANABCF1_HUMANBioGRID30770245 details
TCAM1_HUMANUBP19_HUMANBioGRID31511519 details
TCAM1_HUMANBACD3_HUMANBioGRID31511519 details
TCAM1_HUMANR144B_HUMANBioGRID31509299 details
TCAM1_HUMANPELI1_HUMANBioGRID33052227 details
TCAM1_HUMANTRAM1_HUMANHPRD12721283 details
TCAM1_HUMANPK3CA_HUMANHPRD15940673 details
TCAM1_HUMANTLR2_HUMANHPRD12471095 details
TCAM1_HUMANIKKE_HUMANHPRD12692549 details
TCAM1_HUMANTIRAP_HUMANHPRD14517278 details
TCAM1_HUMANAZI2_HUMANHPRD15611223 details