Entity Details

Primary name LRC8A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IWT6
EntryNameLRC8A_HUMAN
FullNameVolume-regulated anion channel subunit LRRC8A
TaxID9606
Evidenceevidence at protein level
Length810
SequenceStatuscomplete
DateCreated2003-10-03
DateModified2021-06-02

Ontological Relatives

GenesLRRC8A

GO terms

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GOName
GO:0001678 cellular glucose homeostasis
GO:0002329 pre-B cell differentiation
GO:0005225 volume-sensitive anion channel activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006820 anion transport
GO:0006884 cell volume homeostasis
GO:0006970 response to osmotic stress
GO:0007283 spermatogenesis
GO:0009986 cell surface
GO:0015734 taurine transport
GO:0015810 aspartate transmembrane transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032024 positive regulation of insulin secretion
GO:0034214 protein hexamerization
GO:0034702 ion channel complex
GO:0042802 identical protein binding
GO:0045663 positive regulation of myoblast differentiation
GO:0055085 transmembrane transport
GO:0098656 anion transmembrane transport
GO:0140360 cyclic-GMP-AMP transmembrane transporter activity
GO:0140361 cyclic-GMP-AMP transmembrane import across plasma membrane
GO:1902476 chloride transmembrane transport
GO:1905103 integral component of lysosomal membrane

Subcellular Location

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Subcellular Location
Cell membrane
Lysosome membrane

Domains

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DomainNameCategoryType
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR021040 LRRC8, pannexin-like TM regionDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily

Diseases

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