Entity Details

Primary name PIAS4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8N2W9
EntryNamePIAS4_HUMAN
FullNameE3 SUMO-protein ligase PIAS4
TaxID9606
Evidenceevidence at protein level
Length510
SequenceStatuscomplete
DateCreated2003-09-19
DateModified2021-06-02

Ontological Relatives

GenesPIAS4

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003677 DNA binding
GO:0003712 transcription coregulator activity
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008022 protein C-terminus binding
GO:0008270 zinc ion binding
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0016055 Wnt signaling pathway
GO:0016363 nuclear matrix
GO:0016605 PML body
GO:0016925 protein sumoylation
GO:0019789 SUMO transferase activity
GO:0031625 ubiquitin protein ligase binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033235 positive regulation of protein sumoylation
GO:0042359 vitamin D metabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0061665 SUMO ligase activity
GO:1902174 positive regulation of keratinocyte apoptotic process
GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1990234 transferase complex

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003034 SAP domainDomainDomain
IPR004181 Zinc finger, MIZ-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR023321 PINIT domainDomainDomain
IPR027224 E3 SUMO-protein ligase PIAS4FamilyFamily
IPR036361 SAP domain superfamilyFamilyHomologous superfamily
IPR038654 PINIT domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

145 interactions

InteractorPartnerSourcesPublicationsLink
PIAS4_HUMANHD_HUMANBioGRID, HPRD, IntAct15383276 32814053 details
PIAS4_HUMANSUMO2_HUMANBioGRID, HPRD, IntAct15383276 16524884 19394292 22578841 32786267 details
PIAS4_HUMANTADA3_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANBARD1_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANTCRG1_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANCLK1_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANGA45G_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANUBE2K_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANMIC60_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANCHD3_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANIMDH2_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANIMB1_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANMAGH1_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANNFL_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANMLP3A_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANLRIF1_HUMANBioGRID, IntAct15383276 details
PIAS4_HUMANPR40A_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANPTN_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANSUMO3_HUMANHPRD, IntAct15383276 details
PIAS4_HUMANVIME_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANZHX1_HUMANBioGRID, HPRD, IntAct15383276 details
PIAS4_HUMANZ512B_HUMANBioGRID, MINT15231748 details
PIAS4_HUMANSKIL_HUMANBioGRID, HPRD, MINT15231748 details
PIAS4_HUMANSMAD7_HUMANBioGRID, HPRD, MINT12815042 15231748 details
PIAS4_HUMANSMAD1_HUMANBioGRID, HPRD, MINT12904571 15231748 details
PIAS4_HUMANSNIP1_HUMANHPRD, MINT15231748 details
PIAS4_HUMANCACO2_HUMANBioGRID, HPRD, IntAct16189514 details
PIAS4_HUMANP53_HUMANBioGRID, HPRD, IntAct11388671 15383276 details
PIAS4_HUMANPARP1_HUMANBioGRID, MINT19779455 20696768 details
PIAS4_HUMANI15RA_HUMANBioGRID, IntAct21988832 details
PIAS4_HUMANIPSP_HUMANBioGRID, IntAct21988832 details
PIAS4_HUMANALDOA_HUMANBioGRID, IntAct21988832 details
PIAS4_HUMANERR1_HUMANBioGRID, IntAct18063693 21988832 details
PIAS4_HUMANFRIH_HUMANBioGRID, IntAct21988832 details
PIAS4_HUMANK1C18_HUMANBioGRID, IntAct21988832 details
PIAS4_HUMANLAMP2_HUMANBioGRID, IntAct21988832 details
PIAS4_HUMANOAZ1_HUMANBioGRID, IntAct21988832 details
PIAS4_HUMANUBC9_HUMANBioGRID, IntAct12727872 20696768 21988832 22661230 details
PIAS4_HUMANPIAS2_HUMANBioGRID, IntAct21988832 details
PIAS4_HUMANBTAF1_HUMANBioGRID, IntAct21988832 details
PIAS4_HUMANMYOME_HUMANBioGRID, IntAct21988832 details
PIAS4_HUMANOPTN_HUMANBioGRID, IntAct21988832 details
PIAS4_HUMANHNRL1_HUMANBioGRID, IntAct21988832 details
PIAS4_HUMANMPRIP_HUMANBioGRID, IntAct21988832 details
PIAS4_HUMANSERA_HUMANBioGRID, IntAct21988832 details
PIAS4_HUMANPHF11_HUMANBioGRID, IntAct21988832 details
PIAS4_HUMANACTN1_HUMANBioGRID, IntAct21988832 details
PIAS4_HUMANGFI1_HUMANUniProt17636019 details
PIAS4_HUMANSATB1_HUMANBioGRID, IntAct18408014 20351170 details
PIAS4_HUMANZBT34_HUMANBioGRID, IntAct32296183 details
PIAS4_HUMANLCE1D_HUMANBioGRID, IntAct32296183 details
PIAS4_HUMANTRI38_HUMANBioGRID, IntAct32296183 details
PIAS4_HUMANCALR_HUMANIntAct32814053 details
PIAS4_HUMANCADH1_HUMANIntAct32814053 details
PIAS4_HUMANODO2_HUMANIntAct32814053 details
PIAS4_HUMANCD5R1_HUMANIntAct32814053 details
PIAS4_HUMANSAHH2_HUMANIntAct32814053 details
PIAS4_HUMANHXC4_HUMANIntAct32814053 details
PIAS4_HUMANGATA1_HUMANIntAct32814053 details
PIAS4_HUMANCC141_HUMANIntAct32814053 details
PIAS4_HUMANSPA24_HUMANIntAct32814053 details
PIAS4_HUMANF117B_HUMANIntAct32814053 details
PIAS4_HUMANMAGC3_HUMANIntAct32814053 details
PIAS4_HUMANGABP2_HUMANIntAct32814053 details
PIAS4_HUMANBOD1_HUMANIntAct32814053 details
PIAS4_HUMANKKCC1_HUMANIntAct32814053 details
PIAS4_HUMANGPSM3_HUMANIntAct32814053 details
PIAS4_HUMANMYOZ1_HUMANIntAct32814053 details
PIAS4_HUMANCQ080_HUMANIntAct32814053 details
PIAS4_HUMANWBP1L_HUMANIntAct32814053 details
PIAS4_HUMANRBM11_HUMANIntAct32814053 details
PIAS4_HUMANCRLF3_HUMANIntAct32814053 details
PIAS4_HUMANKLF15_HUMANIntAct32814053 details
PIAS4_HUMANITBP2_HUMANIntAct32814053 details
PIAS4_HUMANLAR4B_HUMANIntAct32814053 details
PIAS4_HUMANLPIN1_HUMANIntAct32814053 details
PIAS4_HUMANELL2_HUMANIntAct32814053 details
PIAS4_HUMANHNRPQ_HUMANIntAct32814053 details
PIAS4_HUMANNMT2_HUMANIntAct32814053 details
PIAS4_HUMANZMYM6_HUMANIntAct32814053 details
PIAS4_HUMANSAP30_HUMANIntAct32814053 details
PIAS4_HUMANBECN1_HUMANIntAct32814053 details
PIAS4_HUMANSMRD1_HUMANIntAct32814053 details
PIAS4_HUMANSHOX2_HUMANIntAct32814053 details
PIAS4_HUMANIN35_HUMANIntAct32814053 details
PIAS4_HUMANBACD1_HUMANIntAct32814053 details
PIAS4_HUMANNEK7_HUMANIntAct32814053 details
PIAS4_HUMANA4_HUMANIntAct32814053 details
PIAS4_HUMANLEF1_HUMANBioGRID, HPRD11731474 details
PIAS4_HUMANSMAD6_HUMANBioGRID12815042 details
PIAS4_HUMANSMAD2_HUMANBioGRID, HPRD12815042 12904571 details
PIAS4_HUMANSMAD3_HUMANBioGRID, HPRD12815042 12904571 details
PIAS4_HUMANSMAD4_HUMANBioGRID, HPRD12740389 12815042 12904571 details
PIAS4_HUMANANDR_HUMANBioGRID, HPRD11439351 14981544 details
PIAS4_HUMANBRCA1_HUMANBioGRID20016594 20016603 details
PIAS4_HUMANITF2_HUMANBioGRID12727872 15831457 20211142 details
PIAS4_HUMANCEBPD_HUMANBioGRID18477566 details
PIAS4_HUMANTRI27_HUMANBioGRID15907835 details
PIAS4_HUMANHDAC1_HUMANBioGRID, HPRD12904571 14981544 details
PIAS4_HUMANHDAC2_HUMANBioGRID14981544 details
PIAS4_HUMANTRI32_HUMANBioGRID16816390 details
PIAS4_HUMANKNTC1_HUMANBioGRID20696768 details
PIAS4_HUMANZW10_HUMANBioGRID20696768 details
PIAS4_HUMANKPCZ_HUMANBioGRID21624955 27162139 details
PIAS4_HUMANMDC1_HUMANBioGRID22661230 details
PIAS4_HUMANVHL_HUMANBioGRID20300531 20844582 24002598 details
PIAS4_HUMANSH3G3_HUMANBioGRID15383276 details
PIAS4_HUMANPAIRB_HUMANBioGRID, HPRD16679534 details
PIAS4_HUMANPLAG1_HUMANBioGRID15208321 details
PIAS4_HUMANSUMO1_HUMANBioGRID16524884 details
PIAS4_HUMANPDE4A_HUMANBioGRID20196770 details
PIAS4_HUMANPDE4D_HUMANBioGRID20196770 details
PIAS4_HUMANHNF4A_HUMANBioGRID12727872 details
PIAS4_HUMANTOP2A_HUMANBioGRID20696768 details
PIAS4_HUMANAREL1_HUMANBioGRID27162139 details
PIAS4_HUMANRIF1_HUMANBioGRID, HPRD15383276 29234018 details
PIAS4_HUMANSNAI2_HUMANBioGRID30612578 details
PIAS4_HUMANSETB1_HUMANHPRD15383276 details
PIAS4_HUMANCOIL_HUMANHPRD16219678 details
PIAS4_HUMANNR4A2_HUMANHPRD14559918 details
PIAS4_HUMANTCAM1_HUMANBioGRID, HPRD, MINT15251447 details
PIAS4_HUMANIRF3_HUMANBioGRID, HPRD, MINT15251447 details
PIAS4_HUMANIRF7_HUMANBioGRID, HPRD, MINT15251447 details
PIAS4_HUMANMEN1_HUMANMINT19779455 details
PIAS4_HUMANXRCC6_HUMANMINT19779455 details
PIAS4_HUMANXRCC5_HUMANMINT19779455 details
PIAS4_HUMANANM5_HUMANMINT19779455 details
PIAS4_HUMANHIF1A_HUMANI2D20661221 details
PIAS4_HUMANTF65_HUMANDIP17606919 details
PIAS4_HUMANETS1_HUMANBioGRID16862185 17456046 details
PIAS4_HUMANZMIZ2_HUMANBioGRID20159969 details
PIAS4_HUMANTP53B_HUMANBioGRID20016603 details
PIAS4_HUMANTGM2_HUMANBioGRID19625650 details
PIAS4_HUMANHERC2_HUMANBioGRID22508508 details
PIAS4_HUMANNEMO_HUMANBioGRID16906147 18583959 24457965 25735744 30254148 details
PIAS4_HUMANERBB4_HUMANBioGRID22584572 details
PIAS4_HUMANMECOM_HUMANBioGRID23770046 details
PIAS4_HUMANHIC1_HUMANBioGRID23704280 details
PIAS4_HUMANREV1_HUMANBioGRID25614517 details
PIAS4_HUMANFANCI_HUMANBioGRID25557546 details
PIAS4_HUMANFACD2_HUMANBioGRID25557546 details
PIAS4_HUMANZN746_HUMANBioGRID27086851 details
PIAS4_HUMANRAD51_HUMANBioGRID24046452 details
PIAS4_HUMANCSK_HUMANBioGRID31125786 details
PIAS4_HUMANPIAS1_HUMANHPRD11877418 details